Results 51 to 60 of about 1,306,241 (293)
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
A consensus statement on the use of digital twins in medicine
npj Digital MedicineDigital Health Technologies represent a marked shift from current medical technologies in use, the approach to health and healthcare and stakeholders engaged in healthcare delivery. What the digitalized future of medicine will look like and how it should
Jeffrey David Iqbal +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Core elements of national policy for digital health technology evidence and access
npj Digital MedicineDigital health technologies (DHT) offer the ability to deliver personalized care, lower barriers to access, and positively impact health outcomes. However, DHT utilization is impacted by insufficient market access pathways.
Megan Coder +2 more
doaj +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Development of an evidence-based evaluation framework for digital health software products
Scientific ReportsCurrent frameworks and standards for evaluation of digital health software products (DHSPs) are fragmented and may not cover the spectrum of what stakeholders consider most important.
Jennifer C. Goldsack +5 more
doaj +1 more source
AI product cards: a framework for code-bound formal documentation cards in the public administration
Data & PolicyCurrently, artificial intelligence (AI) is integrated across various segments of the public sector, in a scattered and fragmented manner, aiming to enhance the quality of people’s lives.
Albana Celepija +3 more
doaj +1 more source
CAIT: A Predictive Tool for Supporting the Book Market Operation Using Social Networks
Applied Sciences, 2021 A new predictive support tool for the publishing industry is presented in this note. It consists of a combined model of Artificial Intelligence techniques (CAIT) that seeks the most optimal prediction of the number of book copies, finding out which is ...
Jessie C. Martín Sujo +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
The Journal of Headache and PainBackground Provision of value-based, patient-centered care requires careful appraisal of patients’ symptoms. Understanding subjective experiences, needs, and feelings is crucial for shared decision-making, especially when clinical findings differ from ...
Dominik A. Ettlin +3 more
doaj +1 more source