FEBS Open Bio, EarlyView.The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida +6 more
wiley +1 more source
Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment
Aging and Cancer, EarlyView.Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey +12 more
wiley +1 more source
Juncture stress fields in multicellular shell structures. Volume III - Stresses and deformations on fixed-edge segmental conical shells Final report [PDF]
Equations for thin elastic conical shells and digital program for analysis of stress and deformation on fixed edge segmental conical shells - solution by finite difference ...
Massard, J. M. +2 more
core +1 more source
Computer program calculates steady-state temperature distribution within plane or axisymmetric solids [PDF]
, 1967 Digital computer program, using the finite element analysis technique, determines the steady-state temperature within plan or axisymmetric solids composed of many different materials of various geometry.
Wilson, E. L.
core +1 more source
Adiponectin protects against paraquat-induced lung injury by attenuating oxidative/nitrative stress. [PDF]
, 2014 The specific mechanisms underlying paraquat (PQ)-induced lung injury remain unknown, which limits understanding of its cytotoxic potential. Although oxidative stress has been established as an important mechanism underlying PQ toxicity, multiple ...
Cao, Yu +9 more
core +2 more sources
The Relationship Between Inflammation and Central Nervous System in Multiple Sclerosis
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Aim Multiple sclerosis is an autoimmune demyelination disease that is seen especially in the young population and has a progressive course, causing motor, sensory, and cognitive deficits. In the literature, the pathogenesis of MS disease and the interconnection between the immune and central nervous system in the disease have not been fully ...
Gamze Ansen +5 more
wiley +1 more source
Experimental Study of Interface Shear Transfer of Steel Fiber Reinforced Concrete Members
International Journal of Concrete Structures and MaterialsThis study aimed to evaluate the shear friction strength mechanism of monolithically and separately cast concrete members using steel fiber reinforced concrete (SFRC).
Daun Jeong +3 more
doaj +1 more source
Phenotyping Deficit Moisture Stress Tolerance in Tomato Using Image Derived Digital Features
International Journal of Bio-Resource and Stress Management, 2022 Evaluation of tomato genotypes for the response to water stress using digital features assists in high-throughput phenotyping. A study was conducted on imaging tomato genotypes maintained at field capacity and water deficit stress at flowering stage ...
R. H. Laxman +4 more
doaj
Higher Amyloid and Tau Burden Is Associated With Faster Decline on a Digital Cognitive Test
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective A 2‐min digital clock‐drawing test (DCTclock) captures more granular features of the clock‐drawing process than the pencil‐and‐paper clock‐drawing test, revealing more subtle deficits at the preclinical stage of Alzheimer's disease (AD). A previous cross‐sectional study demonstrated that worse DCTclock performance was associated with
Jessie Fanglu Fu +16 more
wiley +1 more source
Teaching Experience as a Key Factor in Dealing with Digital Teaching Stress
Education SciencesDigital pandemic stress among university faculty has become a key issue in the contemporary era, marked by the rapid transition to online teaching.
Pablo Fernández-Arias +3 more
doaj +1 more source