Results 91 to 100 of about 9,390,859 (327)
Molecular Oncology, EarlyView.Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Reflecting on Digital Art Value: NFTs’ Potential for the Art-Market Parity
Digital Humanities in the Nordic and Baltic Countries PublicationsUntil recently, digital art was perceived as something of secondary value compared to the physical artistic artifacts. One of the reasons for that being its predisposition for duplication and hence the inability to assign “original artwork” label to the
Darja Tokranova, Merja Lina Bauters
doaj +1 more source
Robust Fusion of LiDAR and Wide-Angle Camera Data for Autonomous Mobile Robots
Sensors, 2018 Autonomous robots that assist humans in day to day living tasks are becoming increasingly popular. Autonomous mobile robots operate by sensing and perceiving their surrounding environment to make accurate driving decisions.
Varuna De Silva +2 more
doaj +1 more source
Corporate Digital Entrepreneurship: Leveraging Industrial Internet of Things and Emerging Technologies [PDF]
, 2020 Swapan Ghosh +3 more
openalex +1 more source
Understanding the Role of Digital Technologies in Education: A review
Sustainable Operations and Computers, 2022 Prof. Abid Haleem +3 more
semanticscholar +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Automated Real-Time Localized Sea State Estimation During Navigation Based on the Beaufort Scale
IEEE Open Journal of Intelligent Transportation SystemsThis work presents an automated, real-time approach for localized sea state estimation using a single camera mounted on a ship’s bridge. A labeled dataset of sea surface images, collected during regular operation of an overseas liner, is built and
M. Pobar +3 more
doaj +1 more source