Results 81 to 90 of about 9,390,859 (327)

The educational integration of digital technologies preCovid-19: Lessons for teacher education

PLoS ONE, 2021
The educational integration of Information and Communication Technologies (ICT) has been put to the test because of the need to implement «emergency remote education» as a result of COVID-19.
Jesús Valverde-Berrocoso, M. R. Fernández-Sánchez, Francisco Ignacio Revuelta Dominguez, M. Sosa-Díaz   +3 more
semanticscholar   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Two-dimensional mathematical model of heat and moisture transfer processes during the natural storage and drying of heterogeneous agricultural products [PDF]

BIO Web of Conferences
Developed a two-dimensional mathematical model of simultaneous heat and moisture transfer processes during the natural storage and drying of heterogeneous agricultural products in open areas.
Shadmanov Istam, Nosirova Zarnigor, Kamolova Umida   +2 more
doaj   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Development of an Early Lung Cancer Diagnosis Method Based on a Neural Network

Computers
Cancer is one of the most lethal diseases in the modern world. Early diagnosis significantly contributes to prolonging the life expectancy of patients. The application of intelligent systems and AI methods is crucial for diagnosing oncological diseases ...
Indira Karymsakova, Dinara Kozhakhmetova, Dariga Bekenova, Danila Ostroukh, Roza Bekbayeva, Lazat Kydyralina, Alina Bugubayeva, Dinara Kurushbayeva   +7 more
doaj   +1 more source

On the state feedback control of inverted pendulum with hysteretic nonlinearity

MATEC Web of Conferences, 2014
In this paper we consider the mathematical model of the inverted pendulum with the hysteretic nonlinearity (in the form of backlash) under state feedback control.
Semenov Mikhail E., Grachikov Dmitry V., Rukavitsyn Anton G., Meleshenko Peter A.   +3 more
doaj   +1 more source

Adoption of Digital Technologies in Health Care During the COVID-19 Pandemic: Systematic Review of Early Scientific Literature

Journal of Medical Internet Research, 2020
Background The COVID-19 pandemic is favoring digital transitions in many industries and in society as a whole. Health care organizations have responded to the first phase of the pandemic by rapidly adopting digital solutions and advanced technology tools.
D. Golinelli, E. Boetto, G. Carullo, Andrea Giovanni Nuzzolese, M. Landini, M. Fantini   +5 more
semanticscholar   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

A Program Logic for Reasoning About C11 Programs With Release-Sequences

IEEE Access, 2020
With the popularity of weak/relaxed memory models widely used in modern hardware architectures, the C11 standard introduced a language level weak memory model, A.K.A the C11 memory model, that allows C/C++ programs to exploit the optimisation provided by
Mengda He, Shengchao Qin, Zhiwu Xu
doaj   +1 more source