Results 61 to 70 of about 37,492,001 (308)

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

Integration of BIM and GIS for the Digitization of the Built Environment

Applied Sciences
The integration of Building Information Modelling (BIM) and Geographic Information Systems (GIS) is a growing reality in the building production sector.
Giuseppe Piras, Francesco Muzi, Claudia Zylka   +2 more
doaj   +1 more source

Post-Domestic Living. The Challenge of Adapting Domestic Spaces to the Evolution of Digital Technologies [PDF]

Pad, 2023
The aim of the paper is to examine how the advancement of technology is radically transforming the way we interact with the domestic sphere. The evolution of digital devices has brought new perspectives for redefining living spaces, raising crucial ...
Silvana Donatiello, Mariarita Gagliardi
doaj  

Transitions in Digital Personhood [PDF]

Proceedings of the 2017 CHI Conference on Human Factors in Computing Systems, 2017
We present findings from a qualitative study about how Internet use supports self-functioning following the life transition of retirement from work. This study recruited six recent retirees and included the deployment of OnLines, a design research artifact that logged and visualized key online services used by participants at home over four-weeks.
Abigail Durrant, David S. Kirk, Diego Trujillo-Pisanty, Wendy Moncur, Kathryn M. Orzech, Tom Schofield, Chris Elsden, David J. Chatting, Andrew Monk   +8 more
openaire   +2 more sources

Digital libraries for creative communities [PDF]

, 2004
Digital library technologies have a great deal to offer to creative, design communities. They can enable large collections of text, images, music, video and other information objects to be organised and accessed in interesting and diverse ways.
Jones, Matt, Bainbridge, David, Cantlon, Polly, Cunningham, Sally Jo, Witten, Ian H.   +4 more
core   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins

FEBS Open Bio, EarlyView.
Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley   +1 more source

Austria’s digital transition [PDF]

OECD Economics Department Working Papers, 2017
Austria’s transition to a digital economy and society is slower than in other high-income small open European economies. The rate and pace of utilisation of eight main ICT applications shows that Austrian firms follow peer country counterparts with a gap, which has widened in most areas in recent years.
openaire   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

EcoTechnoPolitics: Towards Planetary Thinking Beyond Digital–Green Twin Transitions

Societies
This article advances EcoTechnoPolitics as a transformational conceptual and policy recommendation framework for hybridizing digital–green twin transitions under conditions of planetary polycrises.
Igor Calzada, Itziar Eizaguirre
doaj   +1 more source