Results 171 to 180 of about 37,610,272 (251)

A Living Multi‐Omics PDX Biobank of High‐Risk Sarcomas Reveals ecDNA‐Driven Oncogene Amplification in Osteosarcoma and Enables Preclinical Precision Oncology

Advanced Science, EarlyView.
A living multi‐omics sarcoma PDX biobank is enriched for high‐risk disease and preserves key patient tumor features at histopathological and molecular levels. Integrated profiling reveals ecDNA‐driven oncogene amplification in osteosarcoma and preferential retention of ecDNA during PDX evolution.
Weisong Zhao, Zhiwei Cheng, Kai Tian, Mengxiong Sun, Zhuoying Wang, Ming Jiao, Jens Luebeck, Kaiyuan Zhu, Xiao Zhang, Dongqing Zuo, Hongsheng Wang, Chongren Wang, Jiakang Shen, Xiaojun Ma, Gangyang Wang, Zongyi Wang, Jing Han, Kaiyuan Liu, Haoran Mu, Weiqi Ma, Yongyong Ren, Shibing Guo, Huangxin Tu, Lingfeng Yu, Yining Tao, Yu Lv, Hui Lu, Owen S. Chapman, Rishaan Kenkre, Lukas Chavez, Zhengdong Cai, Yuqin Yang, Wei Sun, Yafei Jiang, Yingqi Hua   +34 more
wiley   +1 more source

Digital twin based sorting optimization for parcel distribution centers in logistics networks. [PDF]

Nat Commun
Li R, Zhang W, Tian Y, Liu R, Huang B, Liao L, Song X, Qin X, Zhang H, Cui S, Huang C.   +10 more
europepmc   +1 more source

Age‐Related Lamin B1 Deficiency Activates SLC7A11‐Dependent Disulfidptosis to Impair Osteogenesis via Intercepting Mitochondrial Fission

Advanced Science, EarlyView.
This study reveals that age‐related LMNB1 deficiency in mesenchymal stem cells epigenetically upregulates SLC7A11, triggering actin disulfidptosis and mitochondrial dysfunction. This cascade impairs bone formation in senile osteoporosis. Furthermore, researchers identified the FDA‐approved drug naldemedine as a targeted SLC7A11 inhibitor to reverse ...
Wenhui Yu, Qibo Li, Weihao Zhang, Guan Zheng, Junhua Chen, Yipeng Zeng, Zipeng Xiao, Zibin Chen, Ziqian Liu, Yangfeng Lin, Jiajie Lin, Zepeng Su, Zhongyu Xie   +12 more
wiley   +1 more source

Towards Intelligent Membrane Systems: A Critical Analysis of Digital Twin-ML Integration for Real-Time Process Optimization, Fouling Management, and Autonomous Design. [PDF]

Membranes (Basel)
Sadare OO, Alonge SP, Akinyemi AG, Adesina AA, Adesola-Olabiyi S, Fajimi LI.   +5 more
europepmc   +1 more source

Lattice Disorder in CuI Enables Filament‐Free Transparent Memristors

Advanced Science, EarlyView.
Transparent Cu1‐xAgxI thin‐film memristors rely on internal ion transport to produce reversible resistive‐switching effects. Direct elemental characterizations observe obvious Cu and Ag redistribution driven by applied bias, proving mobile ions drive the device's resistive‐switching responses.
Yuzhao Ouyang, Ke Qu, Haonan Wang, Jianquan Liu, Wei Li, Zhuoran Ji, Jialin Yang, Qiuxiang Zhu, Zhenzhong Yang, Xiaodong Tang, Hui Peng, Bobo Tian, Chungang Duan, Chang Yang   +13 more
wiley   +1 more source

Personalized stress detection from wearable physiological signals via Digital Twin-inspired subject embeddings and recurrent neural networks. [PDF]

Front Physiol
Alharbi H.
europepmc   +1 more source

A Compact and Fast Single‐Spike TTFS Encoder With Ultralow Operating Voltage for Efficient Neuromorphic Fourier Transform

Advanced Science, EarlyView.
A Pt/TaOx/V single‐spike TTFS encoder achieves ultralow‐voltage (∼0.35 V), high‐speed (∼100 ns) operation with simplified circuitry. Integrating bipolar nonuniform temporal encoding with a spiking‐DFT neuron model enables a neuromorphic FFT framework. Device‐calibrated simulations demonstrate high spectral fidelity across multitone, speech, and chirp ...
Yang Wu, Qi Wei, Junfeng Zhang, Lirou Su, Ning Mao, Beibei Huang, Jiaying Chen, Dian Huang, Shengzhong Feng, Yishu Zhang, Shuai Zhong   +10 more
wiley   +1 more source

Modelling and simulation of smart city drainage system based on digital twin five-dimensional models. [PDF]

PLoS One
Zhao Y, Yang M.
europepmc   +1 more source

An Environmental Stable Ionogel‐Based Smart Glove System for Integrated Underwater Communication and Safety Warning

Advanced Science, EarlyView.
This study develops a smart glove by integrating a P(BZMA‐co‐HEA)/IL ionogel with a reconfigurable FPCB for underwater communication and real‐time safety warning. The network‐constrained ionic soft‐space regulation strategy enables mechanical reliability, environmental stability, and sensing adaptability, while the modular FPCB sensor array simplifies ...
Xiaoqin Li, Jianwen Liu, Wenhao Yang, Wenjing Yue, Nam‐Young Kim, Young‐Kee Shin, Song Gao, Eun‐Seong Kim, Yang Li   +8 more
wiley   +1 more source

Data‐Driven and Physics‐Informed Modeling Perspectives for Soft Manipulators: From SINDy to Hybrid Intelligence

Advanced Science, EarlyView.
This Perspective charts the modeling landscape for soft manipulators, spanning sparse system identification, neural dynamics, physics‐informed models and hybrid intelligence. We examine how physics, data, sensing, adaptation and control can assume complementary roles within this landscape, and provide a framework for selecting modeling approaches ...
Wenbo Hui, Yunyi Wang, Teng Zhang, Yang Chen, Min Pan   +4 more
wiley   +1 more source