Results 51 to 60 of about 3,807,592 (288)

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

A protocol for a feasibility study of Cognitive Bias Modification training (IVY) countering fatigue in people with breast cancer

Pilot and Feasibility Studies
Background Cancer-related fatigue (CRF) is the most prevalent, distressing, and quality of life disturbing symptom during and after cancer treatment for many cancer types including breast cancer.
Jody A. Geerts, Ester J. M. Siemerink, Falko F. Sniehotta, Lucie J. M. Loman, Christina Bode, Marcel E. Pieterse   +5 more
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Editorial

Weizenbaum Journal of the Digital Society
Securing individual well-being represents an important societal goal. While governments across the world have introduced multiple initiatives to ensure and promote mental health, support for vulnerable population groups remains insufficient ...
Annika Baumann, Margarita Gladkaya, Hanna Krasnova, Hannes-Vincent Krause, Antonia Meythaler   +4 more
doaj   +1 more source

Digital Biomarkers for Well-being Through Exergame Interactions: Exploratory Study

JMIR Serious Games, 2022
BackgroundEcologically valid evaluations of patient states or well-being by means of new technologies is a key issue in contemporary research in health and well-being of the aging population. The in-game metrics generated from the
Despoina Petsani, Evdokimos Konstantinidis, Aikaterini-Marina Katsouli, Vasiliki Zilidou, Sofia B Dias, Leontios Hadjileontiadis, Panagiotis Bamidis   +6 more
doaj   +1 more source

Virtual environments and autism: a developmental psychopathological approach [PDF]

, 2013
Individuals with autism spectrum disorders supposedly have an affinity with ICT, making it an ideally suited media for this population. Virtual environments (VEs) – both two dimensional and immersive – represent a particular kind of ICT that might be of ...
Rajendran, G
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Does the Internet make people happier ? [PDF]

As people are spending more time online, it is important to evaluate the impact of Internet use on individual well-being. Internet use yields direct utility and economic returns (e.g.
Nicolas Poussing, Raphaël Suire, Thierry Pénard   +2 more
core   +3 more sources

From barriers to participation: co-creating an effective reminder letter for breast cancer screening among underserved women in Flanders

Archives of Public Health
Background With over 2 million cases diagnosed annually, breast cancer is a leading cause of cancer-related disability and mortality worldwide. Despite global efforts to implement screening programs, uptake rates vary widely across settings due to ...
Allegra Ferrari, Liesbet Van Bos, Sarah Talboom, Wessel van de Veerdonk, Wendy D’haenens, Marina Pak, Marlies Descan, Stephanie Parmentier, Louise Van Collie, Pascale Sibiet, Mathieu Goossens, Guido Van Hal   +11 more
doaj   +1 more source

Manuscriptorium Digital Library and ENRICH Project: Means for Dealing with Digital Codicology and Palaeography [PDF]

, 2009
Codicology and palaeography in the digital age can be developed both through adapting existing methods and using information and communication technologies.
Knoll, Adolf, Uhlíř, Zdeněk
core