Advanced Science, EarlyView.A healthy gut barrier shields underlying fibroblasts from luminal shear forces, illustrating that “good fences make good neighbors.” Barrier damage exposes fibroblasts to shear stress, inducing cell death and the emergence of stress‐adapted, profibrotic fibroblasts. Sustained shear exposure promotes the formation of stiff aggregates of mechanoadapative
Soyoun Min +6 more
wiley +1 more source
A Digital Workflow for Virtual Articulator Mounting Using Face Scan and Facebow Capture: A Proof-of-Concept. [PDF]
Dent J (Basel)D'Albis G +6 more
europepmc +1 more source
Advanced Science, EarlyView.ABSTRACT Brown and beige adipocytes dissipate energy as heat, yet effective strategies to enhance their mitochondrial efficiency remain limited. Here, we identify Agnuside (AGN) as a selective stabilizer of the complex I assembly factor NDUFAF6. AGN directly binds cytosolic NDUFAF6, suppresses its ubiquitination, prolongs its half‐life, and facilitates
Qingwen Zhao +7 more
wiley +1 more source
Minimally Invasive Replacement of a Missing Lateral Incisor With a Zirconia One-Retainer Bridge Using a Fully Digital Workflow: A Case Report. [PDF]
CureusHouta W, Assila L, El Yamani A.
europepmc +1 more source
Advanced Science, EarlyView.Neuronal PKM2‐driven glycolysis generates excess lactate that triggers histone H3K18 lactylation (H3K18la), establishing a pathogenic metabolic‐epigenetic axis in epilepsy. Elevated H3K18la enriches the Cop1 promoter, transcriptionally upregulating the E3 ubiquitin ligase COP1, which subsequently drives proteasomal degradation of GABAARβ2 and impairs ...
Yuan Meng +8 more
wiley +1 more source
Accuracy of Static Computer-Guided Versus Freehand Implant Placement Using Intraoral Scanner-Based Digital Workflow: A Clinical and Radiographic Study. [PDF]
J Pharm Bioallied SciPatel J +6 more
europepmc +1 more source
A Perspective on Interactive Theorem Provers in Physics
Advanced Science, EarlyView.Into an interactive theorem provers (ITPs), one can write mathematical definitions, theorems and proofs, and the correctness of those results is automatically checked. This perspective goes over the best usage of ITPs within physics and motivates the open‐source community run project PhysLean, the aim of which is to be a library for digitalized physics
Joseph Tooby‐Smith
wiley +1 more source
Resin Composite Injection Technique With a Digital Workflow To Reconstruct Canine Guidance: A Two-Year Follow-Up. [PDF]
J Adhes DentUtsumi Y +5 more
europepmc +1 more source
Advanced Science, EarlyView.ABSTRACT Periodontitis, a chronic inflammatory disease initiated and sustained by plaque microorganisms and host immune response, remains an intractable oral disease and a leading cause of tooth loss worldwide. Traditional mechanical debridement and adjunctive antibiotic or antiseptic therapy often shows limited efficacy due to the complex anatomical ...
Weiyu Zhang +12 more
wiley +1 more source
From Resection to Rehabilitation in One Day: Digital Workflow for Mandibular Reconstruction with Fibular Free Flap and Immediate Dental Rehabilitation Using CAD/CAM Guides at the Point of Care. [PDF]
Craniomaxillofac Trauma ReconstrUreel M +5 more
europepmc +1 more source