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Clinical Pharmacokinetics of Digitoxin
Clinical Pharmacokinetics, 1977The disposition kinetics of digitoxin have not been as thoroughly examined as those of digoxin. Digitoxin appears to be rapidly and completely absorbed after oral or intramuscular administration although there have been no estimates of absolute bioavailabilily.
Frank I. Marcus+2 more
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Interaction of Rifampin and Digitoxin
Archives of Internal Medicine, 1983In a patient who had been receiving digitoxin therapy, the serum digitoxin level decreased markedly when rifampin was added to the therapeutic regimen. The serum digitoxin level returned to the pretreatment level when rifampin therapy was discontinued.
Diana M. Poor+2 more
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The effect of digitoxin on the electrocardiogram
American Heart Journal, 1952Abstract This study would indicate that digotixin changes the order of repolarization in a predictable manner though in an unpredictable amount in both normal and abnormal hearts. The changes in S-T and T as well as Q-T c are best explained by acceleration of repolarization in subendocardial muscle, thus abolishing the normal ventricular gradient ...
William A. Schiess+3 more
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Journal of Cardiovascular Pharmacology and Therapeutics, 2019
We previously showed that digitoxin prolongs the survival of rats with heart failure due to myocardial infarction (MI). In this study, we evaluated the effect of digitoxin on myocardial structure, ventricular function, and proteins involved in calcium ...
C. Picollo+7 more
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We previously showed that digitoxin prolongs the survival of rats with heart failure due to myocardial infarction (MI). In this study, we evaluated the effect of digitoxin on myocardial structure, ventricular function, and proteins involved in calcium ...
C. Picollo+7 more
semanticscholar +1 more source
Digitoxin-Induced Thrombocytopenia
International Archives of Allergy and Immunology, 1972A case of digitoxin-induced thrombocytopenia is reported in a 76-year-old female patient who had been treated with digitoxin over a period of 5 years. This thrombocytopenia was associated with a moderate eosinophilia and clinical signs of severe digitalis intoxication.
K. Hatam+4 more
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Current molecular medicine, 2019
BACKGROUND Store-operated calcium entry (SOCE), primarily mediated by Orai1 and stromal interaction molecule 1 (STIM1), is a major Ca2+ influx pathway that has been linked to human diseases including myopathy, epilepsy, immunodeficiency, and cancer ...
Lijuan Zhou+11 more
semanticscholar +1 more source
BACKGROUND Store-operated calcium entry (SOCE), primarily mediated by Orai1 and stromal interaction molecule 1 (STIM1), is a major Ca2+ influx pathway that has been linked to human diseases including myopathy, epilepsy, immunodeficiency, and cancer ...
Lijuan Zhou+11 more
semanticscholar +1 more source
C12-Hydroxylation of Digitoxin
Nature, 1957USING paper chromatographic methods it has been shown that, following digitoxin administration to rats, the urine contains small amounts of unchanged digitoxin together with larger quantities of two cardioactive metabolites previously designated metabolites C and G 1,2. Human urine collected for 12 hr. from normal adults after an oral dose of 1 mgm. of
B. T. Brown, S. E. Wright, G. T. Okita
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The cardioactivity of digitoxin metabolites
European Journal of Pharmacology, 1971Abstract Using isolated atria, the positive inotropic action of digitoxin and digoxin was compared quantitatively with the cardiac action of metabolites found in guinea pigs. The bis- and monodigitoxoside of digitoxigenin and the monodigitoxoside of digoxigenin showed the strongest inotropic effect with respect to the affinity as well as the maximum ...
Heinz Lüllmann, Thies Peters
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Colorimetric assay of digitoxin
Journal of the American Pharmaceutical Association (Scientific ed.), 1948A colorimetric method in which sodium beta-naphthoquinone-4-sulfonate (purified) is reacted with digitoxin in alkaline solution to form a purple color is proposed for the determination of digitoxin. The purple color quickly reaches a maximum and fades, but the addition of acetic acid at the time of maximum development changes the color to yellow and ...
Louis W. Green+2 more
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Analytical Chemistry, 2015
This study focuses on the quantitative analysis of the cardiac glycoside drug digitoxin and its three main metabolites digitoxigenin-bisdigitoxose, digitoxigenin-monodigitoxose, and digitoxigenin using electrospray ionization-differential ion mobility ...
Caroline Bylda+4 more
semanticscholar +1 more source
This study focuses on the quantitative analysis of the cardiac glycoside drug digitoxin and its three main metabolites digitoxigenin-bisdigitoxose, digitoxigenin-monodigitoxose, and digitoxigenin using electrospray ionization-differential ion mobility ...
Caroline Bylda+4 more
semanticscholar +1 more source