Results 231 to 240 of about 10,900 (273)

Clinical Pharmacokinetics of Digitoxin

Clinical Pharmacokinetics, 1977
The disposition kinetics of digitoxin have not been as thoroughly examined as those of digoxin. Digitoxin appears to be rapidly and completely absorbed after oral or intramuscular administration although there have been no estimates of absolute bioavailabilily.
Frank I. Marcus, Donald Perrier, Michael Mayersohn   +2 more
openaire   +3 more sources

Interaction of Rifampin and Digitoxin

Archives of Internal Medicine, 1983
In a patient who had been receiving digitoxin therapy, the serum digitoxin level decreased markedly when rifampin was added to the therapeutic regimen. The serum digitoxin level returned to the pretreatment level when rifampin therapy was discontinued.
Diana M. Poor, Harry L. Davis, Timothy H. Self   +2 more
openaire   +2 more sources

The effect of digitoxin on the electrocardiogram

American Heart Journal, 1952
Abstract This study would indicate that digotixin changes the order of repolarization in a predictable manner though in an unpredictable amount in both normal and abnormal hearts. The changes in S-T and T as well as Q-T c are best explained by acceleration of repolarization in subendocardial muscle, thus abolishing the normal ventricular gradient ...
William A. Schiess, Gin-Chi Chiu, I.L. Ershler, Robert E. Westlake   +3 more
openaire   +3 more sources

Digitoxin Attenuates Heart Failure, Reduces Myocardial Hypertrophy, and Preserves the Calcium-Binding Proteins in Infarcted Rats

Journal of Cardiovascular Pharmacology and Therapeutics, 2019
We previously showed that digitoxin prolongs the survival of rats with heart failure due to myocardial infarction (MI). In this study, we evaluated the effect of digitoxin on myocardial structure, ventricular function, and proteins involved in calcium ...
C. Picollo, Alexandra A. Santos, E. Antonio, J. A. Silva, D. Bocalini, A. Serra, S. Ihara, P. Tucci   +7 more
semanticscholar   +1 more source

Digitoxin-Induced Thrombocytopenia

International Archives of Allergy and Immunology, 1972
A case of digitoxin-induced thrombocytopenia is reported in a 76-year-old female patient who had been treated with digitoxin over a period of 5 years. This thrombocytopenia was associated with a moderate eosinophilia and clinical signs of severe digitalis intoxication.
K. Hatam, V. Hatam, R. Medenica, R. Junet, J.-P. Girard   +4 more
openaire   +3 more sources

Digitoxin Suppresses Store Operated Calcium Entry by Modulating Phosphorylation and the Pore Region of Orai1.

Current molecular medicine, 2019
BACKGROUND Store-operated calcium entry (SOCE), primarily mediated by Orai1 and stromal interaction molecule 1 (STIM1), is a major Ca2+ influx pathway that has been linked to human diseases including myopathy, epilepsy, immunodeficiency, and cancer ...
Lijuan Zhou, Xiangxiang Chi, Yaping Zhu, Tian Zhang, Jindou Liu, G. Ma, Lian He, Shuce Zhang, Ping Gao, Yubin Zhou, Jin Liu, Youjun Wang   +11 more
semanticscholar   +1 more source

C12-Hydroxylation of Digitoxin

Nature, 1957
USING paper chromatographic methods it has been shown that, following digitoxin administration to rats, the urine contains small amounts of unchanged digitoxin together with larger quantities of two cardioactive metabolites previously designated metabolites C and G 1,2. Human urine collected for 12 hr. from normal adults after an oral dose of 1 mgm. of
B. T. Brown, S. E. Wright, G. T. Okita
openaire   +3 more sources

The cardioactivity of digitoxin metabolites

European Journal of Pharmacology, 1971
Abstract Using isolated atria, the positive inotropic action of digitoxin and digoxin was compared quantitatively with the cardiac action of metabolites found in guinea pigs. The bis- and monodigitoxoside of digitoxigenin and the monodigitoxoside of digoxigenin showed the strongest inotropic effect with respect to the affinity as well as the maximum ...
Heinz Lüllmann, Thies Peters
openaire   +3 more sources

Colorimetric assay of digitoxin

Journal of the American Pharmaceutical Association (Scientific ed.), 1948
A colorimetric method in which sodium beta-naphthoquinone-4-sulfonate (purified) is reacted with digitoxin in alkaline solution to form a purple color is proposed for the determination of digitoxin. The purple color quickly reaches a maximum and fades, but the addition of acetic acid at the time of maximum development changes the color to yellow and ...
Louis W. Green, Frank O. Howland, Alexander T. Warren   +2 more
openaire   +3 more sources

Rapid quantification of digitoxin and its metabolites using differential ion mobility spectrometry-tandem mass spectrometry.

Analytical Chemistry, 2015
This study focuses on the quantitative analysis of the cardiac glycoside drug digitoxin and its three main metabolites digitoxigenin-bisdigitoxose, digitoxigenin-monodigitoxose, and digitoxigenin using electrospray ionization-differential ion mobility ...
Caroline Bylda, R. Thiele, U. Kobold, A. Bujotzek, D. Volmer   +4 more
semanticscholar   +1 more source