Results 201 to 210 of about 92,853 (340)

Hydrogen sulfide promotes lateral root formation in peach through persulfidation of SnRK1α kinase

open access: yesPlant Biotechnology Journal, EarlyView.
Summary Root development is crucial for the growth and yield of horticultural crops. Hydrogen sulfide (H2S), an important gasotransmitter, has been shown to regulate lateral root (LR) formation in plants, including peach (Prunus persica). However, its specific regulatory mechanism remains largely unclear.
Xuelian Wu   +5 more
wiley   +1 more source

Variability in intestinal drug metabolizing enzymes and transporters in Crohn's disease and potential impact on oral drug absorption

open access: yesBritish Journal of Clinical Pharmacology, Volume 91, Issue 7, Page 2028-2044, July 2025.
Aims The aim of study was to generate quantitative data on the abundance of drug‐metabolizing enzymes and transporters (DMETs) in inflamed and non‐inflamed Crohn's disease (CD) ileum and colon, for incorporation into physiologically based pharmacokinetic (PBPK) models, enabling prediction of oral drugs' pharmacokinetics (PK) perturbation in CD patients.
Sarah Alrubia   +4 more
wiley   +1 more source

Four kits for plasma digoxin radioimmunoassay compared. [PDF]

open access: bronze, 1979
Björn Bergdahl   +5 more
openalex   +1 more source

Identification and Clinical Evaluation of Potential Biomarkers for Breast Cancer Resistance Protein (BCRP/ABCG2)

open access: yesClinical Pharmacology &Therapeutics, Volume 118, Issue 1, Page 177-189, July 2025.
Clinical inhibition and genetic variation of the Breast Cancer Resistance Protein (BCRP/ABCG2) efflux transporter can significantly influence drug exposure, highlighting the need for reliable BCRP functional biomarkers. This study aimed to identify and evaluate biomarkers predictive of BCRP function in humans.
Andrew M. Riselli   +16 more
wiley   +1 more source

Concomitant Diabetes and Atrial Fibrillation: Epicardial Fat and Macrophage‐Related Mechanisms

open access: yesDiabetes/Metabolism Research and Reviews, Volume 41, Issue 5, July 2025.
ABSTRACT Type 2 diabetes mellitus (T2DM) is present in 25% of patients with atrial fibrillation (AF), the most prevalent arrhythmia in the world. This concomitant disorder enhances thromboembolic events, length of hospital stay after AF ablation, renal impairment after anticoagulation, heart rate variability after glucose‐lowering treatment, and ...
Saja Al‐rubaye   +3 more
wiley   +1 more source

Intravenous digoxin as a bioavailability standard [PDF]

open access: green, 1975
Roger G. Stoll   +7 more
openalex   +1 more source

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