Results 81 to 90 of about 131,197 (331)

IgG‐Bridging–Seeded Synergistic Aggregation of SARS‐CoV‐2 Spikes Underlies Potent Neutralization by a Low‐Affinity Antibody

Advanced Science, EarlyView.
Low‐affinity antibodies are frequently disregarded in discovery pipelines. This work reports P5‐1C8, a Class 1 SARS‐CoV‐2 antibody with weak trimer binding (KD‐to‐IC50 > 3700‐fold) yet potent neutralization of Omicron JN.1. Structural, biophysical, functional, and coarse‐grained simulations collectively demonstrate that transient inter‐spike IgG ...
Niannian Lv, Peng Chen, Xiaobin Dai, Hu Xu, Ziheng Li, Zelin Shan, Jinqian Li, Fenglin Guo, Yuanfang Chen, Jiayi Li, Yiqian Huang, Guizhi Dong, Yifan Jiang, Liang Chen, Xuanyu Nan, Hanjun Zhao, Kang Zhang, Shilong Fan, Yuanchen Dong, Dongsheng Liu, Xinquan Wang, Deli Huang, Xiaojing Pan, Chunying Chen, Zhihua Liu, Li‐Tang Yan, Qi Zhang, Linqi Zhang, Yuliang Zhao, Yuhe Renee Yang   +29 more
wiley   +1 more source

2-{4-[(Quinolin-8-yloxy)methyl]phenyl}benzonitrile

Acta Crystallographica Section E, 2011
In the title compound, C23H16N2O, the bond angle at the O atom that connects the benzene ring and the quinoline ring system is 116.0 (2)°.
Bin Wei
doaj   +1 more source

Glycine Substitution of Residues with Unfavored Dihedral Angles Improves Protein Thermostability [PDF]

, 2022
LU Zhi-li, Qiaoxian Zhong, Jingxian Li, Bingjie Zhou, Yan-Ni Xing, Kaien Liu, Kexin Cao, Dongming Lan, Teng Zhou, Yonghua Wang, Jiaqi Wang   +10 more
openalex   +1 more source

Structure of ethyl 1-cyanomethyl-5-methoxy-3-phenylindole-2-carboxylate [PDF]

, 1990
C20HI8N203, M r = 334.38, orthorhombic, Pbca, a = 7.179 (3), b = 33.014 (3), c = 14.847 (1) A, V = 3518.85/~3, Z = 8, Dx = 1.262, D m = by 53.1 (3) °.
Chandrakantha, T.N., Nethaji, M., Nirmala, K.A., Puttaraja, .   +3 more
core   +1 more source

Curved Bistable Origami‐Inspired Flexible Transcatheter Mitral Valve Clamping

Advanced Science, EarlyView.
A lightweight bistable curved origami dilator combines reversible deformation and high stability, offering a promising solution for minimally invasive mitral valve repair. Abstract Curved origami exhibits remarkable potential for minimally invasive medical applications owing to its unique geometric programmability and mechanical tunability. Building on
Siyu Gao, Fan Jiang, Xiuting Sun, Peng Qi, Jian Xu   +4 more
wiley   +1 more source

5-Bromo-17-nitro-26,28-prop-2-enoxy-25,27-dipropoxycalix[4]arene

Acta Crystallographica Section E, 2009
Molecules of the title compound, C40H42BrNO6, are located on a crystallographic twofold rotation axis. As a result, the nitro group and bromine residue are mutually disordered with equal occupancies.
doaj   +1 more source

4-(2-{[4-Amino-6-(4-nitrobenzyl)-5-oxo-4,5-dihydro-1,2,4-triazin-3-yl]sulfanyl}acetyl)-3-phenylsydnone

Acta Crystallographica Section E, 2011
In the crystal, C20H15N7O6S, the dihedral angle between the oxadiazole and triazine rings is 86.94 (7)°. The oxadiazole ring makes a dihedral angle of 52.96 (8)° with the phenyl ring, while the triazine ring makes a ...
Hoong-Kun Fun, Mohd Mustaqim Rosli, Nithinchandra, Balakrishna Kalluraya   +3 more
doaj   +1 more source

Golden Ratio Prediction for Solar Neutrino Mixing

, 2009
It has recently been speculated that the solar neutrino mixing angle is connected to the golden ratio phi. Two such proposals have been made, cot theta_{12} = phi and cos theta_{12} = phi/2.
Adisorn Adulpravitchai, Alexander Blum, Altarelli G, Blum A, Blum A Hagedorn C, Everett L L Stuart A J, Fogli G L Lisi E Marrone A Palazzo A Rotunno A M, Schwetz T, Werner Rodejohann   +8 more
core   +3 more sources

Non-dimensional Star-Identification

, 2020
This study introduces a new "Non-Dimensional" star identification algorithm to reliably identify the stars observed by a wide field-of-view star tracker when the focal length and optical axis offset values are known with poor accuracy.
Arnas, David, Leake, Carl, Mortari, Daniele   +2 more
core   +1 more source

Generating Dynamic Structures Through Physics‐Based Sampling of Predicted Inter‐Residue Geometries

Advanced Science, EarlyView.
While static structure prediction has been revolutionized, modeling protein dynamics remains elusive. trRosettaX2‐Dynamics is presented to address this challenge. This framework leverages a Transformer‐based network to predict inter‐residue geometric constraints, guiding conformation generation via physics‐based iterative sampling. The resulting method
Chenxiao Xiang, Wenkai Wang, Zhenling Peng, Jianyi Yang   +3 more
wiley   +1 more source