Results 91 to 100 of about 9,205 (218)

Elucidating the Mechanism of Temporal Adaptation to Hydrogen Peroxide‐Induced Oxidative Stress in Corynebacterium glutamicum

Microbial Biotechnology, Volume 18, Issue 6, June 2025.
In this study, RNA‐seq was employed to investigate the temporal transcriptional response of C. glutamicum ATCC 13032 to external H2O2 at 720 mM (2.45% w/w). The results reveal significant changes in gene expression across multiple pathways, including peroxide scavenging, central metabolism, sulphur and iron metabolism, amino acid biosynthesis, and DNA ...
Chang Yu, Wenjing Hu, Xiaoyu Li, Yu Lei, Dandan Gao, Meng Wang, Ping Zheng, Yan Zhu, Jibin Sun   +8 more
wiley   +1 more source

Induction of dihydrolipoamide dehydrogenase in 3T3-L1 cells during differentiation [PDF]

Biochemical Journal, 1988
The activity and turnover of dihydrolipoamide dehydrogenase (E3), the common component of the three 2-oxoacid dehydrogenase complexes, were measured during the differentiation of 3T3-L1 preadipocytes into 3T3-L1 adipocytes. The specific activity of E3 increased approx.
Donna J. Carothers, Gabriel Pons, Mulchand S. Patel   +2 more
openaire   +3 more sources

AKT1 Phosphorylates FDX1 to Promote Cuproptosis Resistance in Triple‐Negative Breast Cancer

Advanced Science, Volume 12, Issue 17, May 8, 2025.
This study demonstrates that copper activates the AKT signaling pathway, which inhibits ferredoxin‐1 (FDX1), a key regulator of cuproptosis. AKT1‐mediated FDX1 phosphorylation not only abrogates FDX1‐induced cuproptosis and aerobic respiration but also promotes glycolysis.
Zicheng Sun, Huazhen Xu, Guanming Lu, Ciqiu Yang, Xinya Gao, Jing Zhang, Xin Liu, Yongcheng Chen, Kun Wang, Jianping Guo, Jie Li   +10 more
wiley   +1 more source

Mitochondrial alpha-ketoglutarate dehydrogenase complex generates reactive oxygen species [PDF]

, 2004
Mitochondria-produced reactive oxygen species (ROS) are thought to contribute to cell death caused by a multitude of pathological conditions. The molecular sites of mitochondrial ROS production are not well established but are generally thought to be ...
Beal, M. Flint, Browne, SE., Chinopoulos, Christos, Fiskum, G., Lorenzo, BJ., Patel, Mulchand S., Starkov, Anatoly A.   +6 more
core   +1 more source

Cuproplasia and cuproptosis, two sides of the coin

Cancer Communications, Volume 45, Issue 5, Page 505-524, May 2025.
Abstract Copper is an essential micronutrient in the human body, mainly acting as a crucial cofactor required for a wide range of physiological processes across nearly all cell types. Recent advances revealed that tumor cells seize copper to fulfill their rapid proliferation, metastasis, immune evasion, and so on by reprogramming the copper regulatory ...
Kaizhong Lu, Chandra Sugiarto Wijaya, Qinghua Yao, Hongchuan Jin, Lifeng Feng   +4 more
wiley   +1 more source

Partial complementation of pyruvate dehydrogenase deficiency by independently expressed lipoyl and catalytic domains of the dihydrolipoamide acetyltransferase component [PDF]

, 1989
George C. Russell, R. Anthony Williamson, John R. Guest   +2 more
openalex   +2 more sources

3-Hydroxyisobutyryl-CoA hydrolase involved in isoleucine catabolism regulates triacylglycerol accumulation in Phaeodactylum tricornutum [PDF]

, 2017
Since methylmalonyl-CoA epimerase appears to be absent in the majority of photosynthetic organisms, including diatoms, (S)-methylmalonyl-CoA, the intermediate of isoleucine (Ile) catabolism, cannot be metabolized to (R)methylmalonyl-CoA then to succinyl ...
Gong, Yangmin, Hu, Hanhua, Li, Xiaolong, Pan, Yufang, Yang, Juan   +4 more
core   +1 more source

Copper in cancer: friend or foe? Metabolism, dysregulation, and therapeutic opportunities

Cancer Communications, Volume 45, Issue 5, Page 577-607, May 2025.
Abstract Copper, one of the essential nutrients for the human body, acts as an electron relay in multiple pathways due to its redox properties. Both deficiencies and excesses of copper lead to cellular fragility. Therefore, it can manifest pro‐ and anti‐cancer properties in tumors. Therefore, it is crucial to clarify the copper activity within the cell.
Dan Shan, Jinling Song, Yuqing Ren, Yuyuan Zhang, Yuhao Ba, Peng Luo, Quan Cheng, Hui Xu, Siyuan Weng, Anning Zuo, Shutong Liu, Xinwei Han, Jinhai Deng, Zaoqu Liu   +13 more
wiley   +1 more source

Comprehensive Iranian guidelines for the diagnosis and management of maple syrup urine disease: an evidence- and consensus- based approach

Orphanet Journal of Rare Diseases
Maple Syrup Urine Disease (MSUD) disease is a defect in the function of the Branched-chain 2-ketoacid dehydrogenase complex (BCKDH). It is caused by pathogenic biallelic variants in BCKDHA, BCKA decarboxylase, or dihydrolipoamide dehydrogenase. The brain
Noushin Rostampour, Setila Dalili, Hossein Moravej, Zhila Afshar, Negar Yazdani, Seyedeh Tahereh Mousavi, Parastoo Rostami, Daniel Zamanfar, Maryam Yahay, Abdolhossein Nikravesh, Zahra Beyzaei, Mohamad Ahangar Davoodi, Atefeh Sedaghat, Tahora Hakemzadeh, Ali Talea   +14 more
doaj   +1 more source

Quantitative proteomics of a B12 -dependent alga grown in coculture with bacteria reveals metabolic tradeoffs required for mutualism [PDF]

, 2017
The unicellular green alga Lobomonas rostrata requires an external supply of vitamin B12 (cobalamin) for growth, which it can obtain in stable laboratory cultures from the soil bacterium Mesorhizobium loti in exchange for photosynthate.
Amin, Amin, Arrigo, Ashen, Beliaev, Bertrand, Bertrand, Biller, Bradford, Catalano, Chauvin, Cooper, Copley, Croft, Durham, Eisenreich, Elias, Emerich, Falkowski, Fernandes, Geng, González, Grant, Helliwell, Helliwell, Helliwell, Hold, Hom, Kanehisa, Kazamia, Kazamia, Koch, Koch, Liu, Lodwig, Lohse, Longworth, Matsuo, Maxwell, Mus, Nedelcu, Noirel, Ohlrogge, Paerl, Palmer, Pandhal, Panter, Park, Pfaffl, Saalbach, Saibil, Schmollinger, Shargool, Sher, Song, Tai, Thiel, Untergasser, Vizcaíno, Wagner-Döbler, Wienkoop, Xie, Zhang   +62 more
core   +2 more sources