Results 101 to 110 of about 10,826 (186)

Identification of Trypanosoma cruzi Polyamine Transport Inhibitors by Computational Drug Repurposing [PDF]

, 2019
Trypanosoma cruzi is the causative agent of Chagas disease, a parasitic infection endemic in Latin America. In T. cruzi the transport of polyamines is essential because this organism is unable to synthesize these compounds de novo.
Martínez Sayé, Melisa Soledad, Miranda, Mariana Reneé, Pereira, Claudio Alejandro, Phanstiel, Otto, Reigada, Chantal, Valera Vera, Edward Augusto   +5 more
core   +1 more source

Mitochondrial Oxygen Consumption by the Foreskin and its Fibroblast-rich Culture

Sultan Qaboos University Medical Journal, 2013
Objectives: This study investigated the feasibility of using a phosphorescence oxygen analyser to measure cellular respiration (mitochondrial O2 consumption) in foreskin samples and their fibroblast-rich cultures.Methods: Foreskin specimens from normal ...
Fatma Al-Jasmi, Thachillath Pramathan, Adnan Swid, Bahjat Sahari, Harvey S. Penefsky, Abdul-Kader Souid   +5 more
doaj  

Rapid detection of phosphine resistance in the lesser grain borer, Rhyzopertha dominica (Coleoptera: Bostrychidae) from China using ARMS-PCR

Julius-Kühn-Archiv, 2018
The lesser grain borer, Rhyzopertha dominica is one of the serious cosmopolitan stored grain pests worldwide. High phosphine resistant R. dominica has been reported in several countries.
Lu, Yujie, Zhang, Chenguang, Wang, Zhenyan, Yan, Xiaoping, Emery, Robert N.   +4 more
doaj   +1 more source

Identification of potential biomarkers of cuproptosis in cerebral ischemia

Frontiers in Nutrition
ObjectiveCerebral ischemia can cause mild damage to local brain nerves due to hypoxia and even lead to irreversible damage due to neuronal cell death. However, the underlying pathogenesis of this phenomenon remains unclear.
Lihua Qin, Lihua Qin, Xi Cao, Tengjia Huang, Yixin Liu, Sheng Li   +5 more
doaj   +1 more source

Microgliosis, neuronal death, minor behavioral abnormalities and reduced endurance performance in alpha-ketoglutarate dehydrogenase complex deficient mice

Redox Biology
The alpha-ketoglutarate dehydrogenase complex (KGDHc), also known as the 2-oxoglutarate dehydrogenase complex, plays a crucial role in oxidative metabolism.
Márton Kokas, András Budai, Andrea Kádár, Soroosh Mozaffaritabar, Lei Zhou, Tímea Téglás, Rebeka Sára Orova, Dániel Gáspár, Kristóf Németh, Daniel Marton Toth, Nabil V. Sayour, Csenger Kovácsházi, Andrea Xue, Réka Zsuzsanna Szatmári, Beáta Törőcsik, Domokos Máthé, Noémi Kovács, Krisztián Szigeti, Péter Nagy, Ildikó Szatmári, Csaba Fekete, Tamás Arányi, Zoltán V. Varga, Péter Ferdinandy, Zsolt Radák, Andrey V. Kozlov, László Tretter, Tímea Komlódi, Attila Ambrus   +28 more
doaj   +1 more source

Mitochondrial lipoylation integrates age-associated decline in brown fat thermogenesis. [PDF]

, 2019
Thermogenesis in brown adipose tissue (BAT) declines with age; however, what regulates this process remains poorly understood. Here, we identify mitochondria lipoylation as a previously unappreciated molecular hallmark of aged BAT in mice.
Chang, Chih-Hsiang, Chang, Hsin-Yi, Ikeda, Kenji, Ishihama, Yasushi, Jun, Heejin, Kajimura, Shingo, Oguri, Yasuo, Tajima, Kazuki, Wu, Jun, Yoneshiro, Takeshi   +9 more
core  

3-Hydroxyisobutyryl-CoA hydrolase involved in isoleucine catabolism regulates triacylglycerol accumulation in Phaeodactylum tricornutum [PDF]

, 2017
Since methylmalonyl-CoA epimerase appears to be absent in the majority of photosynthetic organisms, including diatoms, (S)-methylmalonyl-CoA, the intermediate of isoleucine (Ile) catabolism, cannot be metabolized to (R)methylmalonyl-CoA then to succinyl ...
Gong, Yangmin, Hu, Hanhua, Li, Xiaolong, Pan, Yufang, Yang, Juan   +4 more
core   +1 more source

dldhcri3 zebrafish exhibit altered mitochondrial ultrastructure, morphology, and dysfunction partially rescued by probucol or thiamine

JCI Insight
Dihydrolipoamide dehydrogenase (DLD) deficiency is a recessive mitochondrial disease caused by variants in DLD, the E3 subunit of mitochondrial α-keto (or 2-oxo) acid dehydrogenase complexes.
Manuela Lavorato, Donna Iadarola, Cristina Remes, Prabhjot Kaur, Chynna Broxton, Neal D. Mathew, Rui Xiao, Christoph Seiler, Eiko Nakamaru-Ogiso, Vernon E. Anderson, Marni J. Falk   +10 more
doaj   +1 more source

Structural and Biochemical Investigation of Selected Pathogenic Mutants of the Human Dihydrolipoamide Dehydrogenase. [PDF]

Int J Mol Sci, 2023
Szabo E, Nemes-Nikodem E, Vass KR, Zambo Z, Zrupko E, Torocsik B, Ozohanics O, Nagy B, Ambrus A.   +8 more
europepmc   +1 more source

The Effects of a Ketogenic Diet on Patients with Dihydrolipoamide Dehydrogenase Deficiency. [PDF]

Nutrients, 2021
Staretz-Chacham O, Pode-Shakked B, Kristal E, Abraham SY, Porper K, Wormser O, Shelef I, Anikster Y.   +7 more
europepmc   +1 more source