Results 111 to 120 of about 9,205 (218)

Identification of potential biomarkers of cuproptosis in cerebral ischemia

Frontiers in Nutrition
ObjectiveCerebral ischemia can cause mild damage to local brain nerves due to hypoxia and even lead to irreversible damage due to neuronal cell death. However, the underlying pathogenesis of this phenomenon remains unclear.
Lihua Qin, Lihua Qin, Xi Cao, Tengjia Huang, Yixin Liu, Sheng Li   +5 more
doaj   +1 more source

The role of amino acids T148 and R281 in human dihydrolipoamide dehydrogenase

Journal of Biomedical Science, 2007
Human dihydrolipoamide dehydrogenase (hE3) is a common component of alpha-ketoacid dehydrogenase complexes. Mutations of this homodimeric protein cause E3 deficiency and are always fatal. To investigate its reaction mechanism, we first performed multiple sequence alignment with other 17 eukaryotic E3s.
Ling-Yun Chen, Ming-Chih Chou, Yi-Chun Wang, Pei-Ru Chen, Ted-Chung Liu, Shih-Tsung Wang, Wen-Hu Liu, Chuan Li   +7 more
openaire   +3 more sources

Proteome- and Transcriptome-Driven Reconstruction of the Human Myocyte Metabolic Network and Its Use for Identification of Markers for Diabetes

Cell Reports, 2015
Skeletal myocytes are metabolically active and susceptible to insulin resistance and are thus implicated in type 2 diabetes (T2D). This complex disease involves systemic metabolic changes, and their elucidation at the systems level requires genome-wide ...
Leif Väremo, Camilla Scheele, Christa Broholm, Adil Mardinoglu, Caroline Kampf, Anna Asplund, Intawat Nookaew, Mathias Uhlén, Bente Klarlund Pedersen, Jens Nielsen   +9 more
doaj   +1 more source

Changes in the proteome of pea (Pisum sativum L.) seeds germinating under optimal and osmotic stress conditions and subjected to post-stress recovery [PDF]

, 2013
Plants growing under natural conditions are exposed to a variety of stresses, which can lead to undesirable changes in the physiological processes and yielding.
Brosowska-Arendt, W., Gallardo-Guerrero, Karine, Sommerer, Nicolas, Weidner, S.   +3 more
core   +3 more sources

Purification and comparative studies of dihydrolipoamide dehydrogenases from the anaerobic, glycine-utilizing bacteria Peptostreptococcus glycinophilus, Clostridium cylindrosporum, and Clostridium sporogenes [PDF]

, 1990
D Dietrichs, Jan R. Andreesen
openalex   +1 more source

Structural and Biochemical Investigation of Selected Pathogenic Mutants of the Human Dihydrolipoamide Dehydrogenase. [PDF]

Int J Mol Sci, 2023
Szabo E, Nemes-Nikodem E, Vass KR, Zambo Z, Zrupko E, Torocsik B, Ozohanics O, Nagy B, Ambrus A.   +8 more
europepmc   +1 more source

FAD Insertion Is Essential for Attaining the Assembly Competence of the Dihydrolipoamide Dehydrogenase (E3) Monomer fromEscherichia coli [PDF]

, 2000
Heather Lindsay, Ellen S. Beaumont, Susan D. Richards, Sharon M. Kelly, Sanya J. Sanderson, Nicholas C. Price, J. Gordon Lindsay   +6 more
openalex   +1 more source

Cloning, overexpression and mutagenesis of cDNA encoding dihydrolipoamide succinyltransferase component of the porcine 2-oxoglutarate dehydrogenase complex [PDF]

, 2000
Kichiko Koike, Takashi Suematsu, Masahiko Ehara   +2 more
openalex   +1 more source

Mitochondrial p32/C1qbp Is a Critical Regulator of Dendritic Cell Metabolism and Maturation

Cell Reports, 2018
Summary: Dendritic cell (DC) maturation induced by Toll-like receptor agonists requires activation of downstream signal transduction and metabolic changes. The endogenous metabolite citrate has recently emerged as a modulator of DC activation.
Kazuhito Gotoh, Takafumi Morisaki, Daiki Setoyama, Katsuhiko Sasaki, Mikako Yagi, Ko Igami, Soichi Mizuguchi, Takeshi Uchiumi, Yoshinori Fukui, Dongchon Kang   +9 more
doaj  

Cuproptosis, the novel type of oxidation-induced cell death in thoracic cancers: can it enhance the success of immunotherapy?

Cell Communication and Signaling
Copper is an important metal micronutrient, required for the balanced growth and normal physiological functions of human organism. Copper-related toxicity and dysbalanced metabolism were associated with the disruption of intracellular respiration and the
Ruiwen Zhao, Olga Sukocheva, Edmund Tse, Margarita Neganova, Yulia Aleksandrova, Yufei Zheng, Hao Gu, Deyao Zhao, SabbaRao V. Madhunapantula, Xiaorong Zhu, Junqi Liu, Ruitai Fan   +11 more
doaj   +1 more source