Results 111 to 120 of about 10,826 (186)

Cuproptosis, the novel type of oxidation-induced cell death in thoracic cancers: can it enhance the success of immunotherapy?

Cell Communication and Signaling
Copper is an important metal micronutrient, required for the balanced growth and normal physiological functions of human organism. Copper-related toxicity and dysbalanced metabolism were associated with the disruption of intracellular respiration and the
Ruiwen Zhao, Olga Sukocheva, Edmund Tse, Margarita Neganova, Yulia Aleksandrova, Yufei Zheng, Hao Gu, Deyao Zhao, SabbaRao V. Madhunapantula, Xiaorong Zhu, Junqi Liu, Ruitai Fan   +11 more
doaj   +1 more source

Dihydrolipoamide dehydrogenase, pyruvate oxidation, and acetylation-dependent mechanisms intersecting drug iatrogenesis. [PDF]

Cell Mol Life Sci, 2021
Duarte IF, Caio J, Moedas MF, Rodrigues LA, Leandro AP, Rivera IA, Silva MFB.   +6 more
europepmc   +1 more source

The Computational Analysis and Phytochemical Screening Targeting Dihydrolipoamide Dehydrogenase (DLD) for Alzheimer's Disease: A Molecular Dynamics Simulation Study

European Journal of Volunteering and Community-Based Projects
The decreasing rate of metabolisms within the mitochondrial is connected to the progressive characterization of Alzheimer's Disease (AD). Dihydrolipoamide dehydrogenase (dld), and DLD1 are specific chemicals comprised of two enzymes/complexes of protein;
Muhammad Mazhar Fareed
doaj   +2 more sources

A preserved TGFβ cytostatic response through DLD-mediated metabolic modulation undermines anti-TGFβ therapy in gastric cancer

Nature Communications
Despite the well-known role of the transforming growth factor-β (TGFβ) pathway in cancer progression, therapies targeting it have largely failed in the clinic. This suggests our understanding of TGFβ’s function is incomplete.
Yi-Qian Pan, Yi Han, Zheng-Yu Qian, Xin-Yao Zhang, Ting-Ting Wang, Ze-Rong Cai, Huan Chen, Yun Li, Kun Liao, Yong-Qiang Zheng, Yan-Yu Zhang, Qi-Nian Wu, Hao-Xiang Wu, Tian Tian, Wenqi Chen, Yue Chen, Zhao-Lei Zeng, Ze-Xian Liu, Hai-Long Piao, Xin-Yuan Guan, Rui-Hua Xu, Huai-Qiang Ju   +21 more
doaj   +1 more source

Mitochondrial KMT9 methylates DLAT to control pyruvate dehydrogenase activity and prostate cancer growth

Nature Communications
Prostate cancer (PCa) growth depends on de novo lipogenesis controlled by the mitochondrial pyruvate dehydrogenase complex (PDC). In this study, we identify lysine methyltransferase (KMT)9 as a regulator of PDC activity. KMT9 is localized in mitochondria
Yanhan Jia, Sheng Wang, Sylvia Urban, Judith M. Müller, Manuela Sum, Qing Wang, Helena Bauer, Uwe Schulte, Heike Rampelt, Nikolaus Pfanner, Katrin M. Schüle, Axel Imhof, Ignasi Forné, Christopher Berlin, August Sigle, Christian Gratzke, Holger Greschik, Eric Metzger, Roland Schüle   +18 more
doaj   +1 more source

Dynamics of Adaptive Microevolution of Hypermutable Pseudomonas aeruginosa during Chronic Pulmonary Infection in Patients with Cystic Fibrosis [PDF]

, 2009
Eichner, Anja, Heesemann, Jürgen, Henke, Chrstine, Hoboth, Christina, Hoffmann, Reinhard, Hogardt, Michael, Imhof, Axel, Schmold, Sabine   +7 more
core   +1 more source

Depletion of Branched-Chain Aminotransferase 2 (BCAT2) Enzyme Impairs Myoblast 3 Survival and Myotube Formation [PDF]

, 2019
Much is known about the positive effects of branched-chain amino acids (BCAA) in regulating muscle protein metabolism. Comparatively much less is known about the effects of these amino acids and their metabolites in regulating myotube formation.
ADEGOKE, OLASUNKANMI, Dhanani, Zameer N., Mann, Gagandeep   +2 more
core  

Suppression of a core metabolic enzyme dihydrolipoamide dehydrogenase (dld) protects against amyloid beta toxicity in C. elegans model of Alzheimer's disease. [PDF]

Genes Dis, 2021
Ahmad W, Ebert PR.
europepmc   +1 more source

Dihydrolipoamide Dehydrogenase-binding Protein of the Human Pyruvate Dehydrogenase Complex [PDF]

Journal of Biological Chemistry, 1997
Robert A. Harris, Melissa M. Bowker-Kinley, Pengfei Wu, Jingjau Jeng, Kirill M. Popov   +4 more
openaire   +1 more source

A cuproptosis-related prognostic signature for guiding clinical diagnosis and treatment in uveal melanoma patients

Heliyon
Background: Cuproptosis, one of the most recently discovered forms of cell death, is induced by the disruption of copper binding to the mitochondrial respiratory acylation components.
Ying Yang, Qixuan Li, Jia Chen, Yangchen Guo, Yu Cai, Wenmin Zhao, Shu Su, Aimin Sang   +7 more
doaj   +1 more source