Results 111 to 120 of about 9,017 (241)

Purification and Characterization of an Arene cis-Dihydrodiol Dehydrogenase Endowed with Broad Substrate Specificity toward Polycyclic Aromatic Hydrocarbon Dihydrodiols [PDF]

Applied and Environmental Microbiology 72 (2006) 4726-4734, 2009
Initial reactions involved in the bacterial degradation of polycyclic aromatic hydrocarbons (PAHs) include a ring-dihydroxylation catalyzed by a dioxygenase and a subsequent oxidation of the dihydrodiol products by a dehydrogenase. In this study, the dihydrodiol dehydrogenase from the PAH-degrading Sphingomonas strain CHY-1 has been characterized.
arxiv  

An up‐To‐Date Review of Elesclomol and Its Nano‐Formulations in Cancer Therapy

Cancer Reports, Volume 8, Issue 4, April 2025.
ABSTRACT Background Elesclomol (ES) is a promising anticancer compound that exerts its effects through multiple mechanisms. It acts as a copper (Cu(II)) ionophore, forming an ES–Cu complex within cancer cells and inducing a novel form of cell death called cuproptosis.
Qi Wang, Feng Li, Amit K. Tiwari, R. Jayachandra Babu   +3 more
wiley   +1 more source

Partial complementation of pyruvate dehydrogenase deficiency by independently expressed lipoyl and catalytic domains of the dihydrolipoamide acetyltransferase component [PDF]

, 1989
George C. Russell, R. Anthony Williamson, John R. Guest   +2 more
openalex   +2 more sources

Glycine encephalopathy

The Egyptian Journal of Neurology, Psychiatry and Neurosurgery, 2022
Inherited neurotransmitter diseases are a subset of rare neurometabolic disorders characterized by hereditary deficiencies in neurotransmitter metabolism or transport.
S. Bhumika, Kanthesh M. Basalingappa, T. S. Gopenath, Suman Basavaraju   +3 more
doaj   +1 more source

Definitive host influences the proteomic profile of excretory/secretory products of the trematode Echinostoma caproni [PDF]

, 2016
Detailed gel images of the differential spots identified by mass spectrometry and database search. Magnification of the 2D gel-areas corresponding to the 19 differentially expressed spots identified by mass spectrometry and database search.
Alba Cortés, Carla Muñoz-Antolí, J. Guillermo Esteban, Javier Sotillo, María Trelis, Rafael Toledo   +5 more
core   +5 more sources

Comprehensive Iranian guidelines for the diagnosis and management of maple syrup urine disease: an evidence- and consensus- based approach

Orphanet Journal of Rare Diseases
Maple Syrup Urine Disease (MSUD) disease is a defect in the function of the Branched-chain 2-ketoacid dehydrogenase complex (BCKDH). It is caused by pathogenic biallelic variants in BCKDHA, BCKA decarboxylase, or dihydrolipoamide dehydrogenase. The brain
Noushin Rostampour, Setila Dalili, Hossein Moravej, Zhila Afshar, Negar Yazdani, Seyedeh Tahereh Mousavi, Parastoo Rostami, Daniel Zamanfar, Maryam Yahay, Abdolhossein Nikravesh, Zahra Beyzaei, Mohamad Ahangar Davoodi, Atefeh Sedaghat, Tahora Hakemzadeh, Ali Talea   +14 more
doaj   +1 more source

Gut Microbiome and Metabolome Changes in Chronic Low Back Pain Patients With Vertebral Bone Marrow Lesions

JOR SPINE, Volume 8, Issue 1, March 2025.
This study explores the link between the gut microbiome, serum metabolome, and fatty replacement (FR) in chronic low back pain (LBP) patients. Findings reveal that dysbiosis in the gut microbiome and altered branched‐chain amino acid (BCAA) levels contribute to FR through the SIRT4 pathway, suggesting potential therapeutic strategies targeting gut ...
Wentian Li, Ji Tu, Jinjian Zheng, Abhirup Das, Qi Yan, Xiaotao Jiang, Wenyuan Ding, Xupeng Bai, Kaitao Lai, Sidong Yang, Cao Yang, Jun Zou, Ashish D. Diwan, Zhaomin Zheng   +13 more
wiley   +1 more source

Hepatitis B Virus Core Promoter Double Mutations (A1762T, G1764A) Are Associated with Lower Levels of Serum Dihydrolipoyl Dehydrogenase [PDF]

, 2016
Published by S. Karger AG, BaselObjectives: The aim of this study was to identify serum proteins with differential concentrations between hepatocellular carcinoma (HCC) patients and HBsAg asymptomatic carriers among individuals infected with hepatitis B ...
Chen, QY, Fang, ZL, Harrison, TJ, Hu, LP, Jiang, ZH, Li, GJ, Li, H, Li, KW, Tan, C, Wang, XY, Yang, QL   +10 more
core   +2 more sources

Asperuloside stimulates metabolic function in rats across several organs under high-fat diet conditions, acting like the major ingredient of Eucommia leaves with anti-obesity activity

Journal of Nutritional Science, 2012
Eucommia leaves (Eucommia ulmoides Oliver) contain chlorogenic acid (a caffeic acid derivative) and geniposidic acid and asperuloside (ASP), iridoid glucosides used in beverages. We used a metabolic syndrome rat model, produced by feeding a 35 % high-fat
Takahiko Fujikawa, Tetsuya Hirata, Shingo Hosoo, Kenji Nakajima, Atsunori Wada, Yutaka Yurugi, Hideaki Soya, Takashi Matsui, Akihiko Yamaguchi, Masato Ogata, Sansei Nishibe   +10 more
doaj   +1 more source

Pulmonary Hypertension: Molecular Mechanisms and Clinical Studies

MedComm, Volume 6, Issue 3, March 2025.
The figure highlights the interplay of genetic and epigenetic mechanisms in pulmonary hypertension (PH) and their implications for therapeutic strategies. The genetic mechanism section features key genes implicated in PH pathogenesis. The epigenetic mechanism encompasses DNA methylation, RNA methylation, noncoding RNAs (miRNA, lncRNA), and histone ...
Joseph Adu‐Amankwaah, Qiang You, Xiaoer Liu, Jiayi Jiang, Dongqi Yang, Kuntao Liu, Jinxiang Yuan, Yanfang Wang, Qinghua Hu, Rubin Tan   +9 more
wiley   +1 more source