Localization of the human dihydrolipoamide dehydrogenase gene (DLD) to 7q31→q32 [PDF]
Cytogenetic and Genome Research, 1991 The gene for human dihydrolipoamide dehydrogenase (DLD) has been localized to the long arm of chromosome 7, within bands q31→q32, by gel-blot hybridization analysis with DNA from a panel of somatic cell hybrids containing various portions of human ...
Otulakowski, G +3 more
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Targeted Redox Regulation α-Ketoglutarate Dehydrogenase Complex for the Treatment of Human Diseases [PDF]
Cellsα-ketoglutarate dehydrogenase complex (KGDHc) is a crucial enzyme in the tricarboxylic acid (TCA) cycle that intersects monosaccharides, amino acids, and fatty acid catabolism with oxidative phosphorylation (OxPhos). A key feature of KGDHc is its ability
Ryan J. Mailloux
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Roles of Dihydrolipoamide Dehydrogenase in Health and Disease. [PDF]
Antioxid Redox Signal, 2023 Significance: Dihydrolipoamide dehydrogenase (DLDH) is a flavin-dependent disulfide oxidoreductase. The active form of DLDH is a stable homodimer, and its deficiencies have been linked to numerous metabolic disorders. A better understanding of redox and nonredox features of DLDH may reveal druggable targets for disease interventions or preventions ...
Yan LJ, Wang Y.
europepmc +3 more sources
The Effects of a Ketogenic Diet on Patients with Dihydrolipoamide Dehydrogenase Deficiency. [PDF]
Nutrients, 2021 Background: Dihydrolipoamide dehydrogenase (DLD lipoamide dehydrogenase, the E3 subunit of the pyruvate dehydrogenase complex (PDHC)) is the third catalytic enzyme of the PDHC, which converts pyruvate to acetyl-CoA catalyzed with the introduction of acetyl-CoA to the tricyclic acid (TCA) cycle.
Staretz-Chacham O +7 more
europepmc +4 more sources
Immunoinformatic development of a multiepitope messenger RNA vaccine targeting lipoate protein ligase and dihydrolipoamide dehydrogenase proteins of <i>Mycoplasma bovis</i> in cattle. [PDF]
Vet WorldAl-Fetly DR, Alsallami D, Alsultan A.
europepmc +2 more sources
Cryptic proteolytic activity of dihydrolipoamide dehydrogenase [PDF]
Proceedings of the National Academy of Sciences, 2007 The mitochondrial enzyme, dihydrolipoamide dehydrogenase (DLD), is essential for energy metabolism across eukaryotes. Here, conditions known to destabilize the DLD homodimer enabled the mouse, pig, or human enzyme to function as a protease. A catalytic dyad (S456–E431) buried at the homodimer interface was identified.
Ngolela Esther Babady +3 more
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RGD-modified dihydrolipoamide dehydrogenase conjugated to titanium dioxide nanoparticles - switchable integrin-targeted photodynamic treatment of melanoma cells. [PDF]
RSC Adv, 2018 Dayan A, Fleminger G, Ashur-Fabian O.
europepmc +3 more sources
GLS2 inhibition synergizes with copper to reprogram TCA cycle for cuproptosis-driven radiosensitization in esophageal cancer [PDF]
Experimental Hematology & OncologyEsophageal squamous cell carcinoma (ESCC) is notorious for its poor prognosis. In the present study, the role of glutaminase 2 (GLS2) and copper (Cu) in the radiosensitivity of ESCC was explored.
Wang Jing +7 more
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Reactions, 2022 The E. coli 2-oxoglutarate dehydrogenase complex (OGDHc) is a multienzyme complex in the tricarboxylic acid cycle, consisting of multiple copies of three components, 2-oxoglutarate dehydrogenase (E1o), dihydrolipoamide succinyltransferase (E2o) and ...
Joydeep Chakraborty +7 more
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Hamster Sperm Capacitation: Role of Pyruvate Dehydrogenase A and Dihydrolipoamide Dehydrogenase1 [PDF]
Biology of Reproduction, 2008 Recently, we demonstrated that pyruvate dehydrogenase A2 (PDHA2) is tyrosine phosphorylated in capacitated hamster spermatozoa. In this report, using bromopyruvate (BP), an inhibitor of PDHA, we demonstrated that hamster sperm hyperactivation was blocked regardless of whether PDHA was inhibited prior to or after the onset of hyperactivation, but the ...
Vivek Kumar, Venkatesh Kota, S. Shivaji
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