Results 21 to 30 of about 289,389 (237)

Inhibiting sperm pyruvate dehydrogenase complex and its E3 subunit, dihydrolipoamide dehydrogenase affects fertilization in Syrian hamsters. [PDF]

open access: goldPLoS ONE, 2014
BACKGROUND/AIMS: The importance of sperm capacitation for mammalian fertilization has been confirmed in the present study via sperm metabolism.
Archana B Siva   +5 more
doaj   +3 more sources

Development of Recombinant Dihydrolipoamide Dehydrogenase Subunit Vaccine against Vibrio Infection in Large Yellow Croaker

open access: yesFishes, 2022
Large yellow croaker (Larimichthys crocea), an economically important marine fish in China, has suffered from serious vibriosis, which has resulted in great economic losses for the large yellow croaker industry.
Xiaomeng Li   +6 more
doaj   +2 more sources

Rearrangement of mitochondrial pyruvate dehydrogenase subunit dihydrolipoamide dehydrogenase protein-protein interactions by the MDM2 ligand nutlin-3. [PDF]

open access: yesProteomics, 2016
Drugs targeting MDM2's hydrophobic pocket activate p53. However, these agents act allosterically and have agonist effects on MDM2's protein interaction landscape. Dominant p53-independent MDM2-drug responsive-binding proteins have not been stratified. We
Way L   +7 more
europepmc   +4 more sources

The natural history of dihydrolipoamide dehydrogenase deficiency in Israel

open access: yesJournal of Inherited Metabolic Disease
Dihydrolipoamide dehydrogenase (DLD) deficiency is an ultra‐rare autosomal‐recessive inborn error of metabolism, affecting no less than five mitochondrial multienzyme complexes.
B. Pode-Shakked   +11 more
semanticscholar   +3 more sources

A pH-dependent kinetic model of dihydrolipoamide dehydrogenase from multiple organisms. [PDF]

open access: yesBiophys J, 2014
Dihydrolipoamide dehydrogenase is a flavoenzyme that reversibly catalyzes the oxidation of reduced lipoyl substrates with the reduction of NAD+ to NADH.
Moxley MA, Beard DA, Bazil JN.
europepmc   +2 more sources

The Pyruvate and α-Ketoglutarate Dehydrogenase Complexes of Pseudomonas aeruginosa Catalyze Pyocyanin and Phenazine-1-carboxylic Acid Reduction via the Subunit Dihydrolipoamide Dehydrogenase. [PDF]

open access: yesJ Biol Chem, 2017
Phenazines are a class of redox-active molecules produced by diverse bacteria and archaea. Many of the biological functions of phenazines, such as mediating signaling, iron acquisition, and redox homeostasis, derive from their redox activity.
Glasser NR, Wang BX, Hoy JA, Newman DK.
europepmc   +3 more sources

An Updated View on the Molecular Pathomechanisms of Human Dihydrolipoamide Dehydrogenase Deficiency in Light of Novel Crystallographic Evidence. [PDF]

open access: yesNeurochem Res, 2019
Dihydrolipoamide dehydrogenase (LADH, E3) deficiency is a rare (autosomal, recessive) genetic disorder generally presenting with an onset in the neonatal age and early death; the highest carrier rate has been found among Ashkenazi Jews.
Ambrus A.
europepmc   +2 more sources

Underlying molecular alterations in human dihydrolipoamide dehydrogenase deficiency revealed by structural analyses of disease-causing enzyme variants. [PDF]

open access: yesHum Mol Genet, 2019
Human dihydrolipoamide dehydrogenase (hLADH, hE3) deficiency (OMIM# 246900) is an often prematurely lethal genetic disease usually caused by inactive or partially inactive hE3 variants.
Szabo E   +14 more
europepmc   +2 more sources

Reciprocal regulation of protein synthesis and carbon metabolism for thylakoid membrane biogenesis. [PDF]

open access: yesPLoS Biology, 2013
Metabolic control of gene expression coordinates the levels of specific gene products to meet cellular demand for their activities. This control can be exerted by metabolites acting as regulatory signals and/or a class of metabolic enzymes with dual ...
Alexandra-Viola Bohne   +6 more
doaj   +5 more sources

Cloning and cDNA sequence of the dihydrolipoamide dehydrogenase component of human ketoacid dehydrogenase complexes [PDF]

open access: green, 2023
cDNA clones comprising the entire coding region for human dihydrolipoamide dehydrogenase (dihydrolipoamide:NAD+ oxidoreductase, EC 1.8.1.4) have been isolated from a human liver cDNA library.
Carothers, Donna J.   +8 more
core   +2 more sources

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