Results 61 to 70 of about 3,572 (156)

Short‐chain acyl post‐translational modifications in cancers: Mechanisms, roles, and therapeutic implications

Cancer Communications, Volume 45, Issue 10, Page 1247-1284, October 2025.
Abstract Post‐translational modifications (PTMs) play a pivotal role in epigenetic regulation and are key pathways for modulating protein functionality. PTMs involve the covalent attachment of distinct chemical groups, such as succinyl, crotonyl, and lactyl, at specific protein sites, which alter protein structure, function, stability, and activity ...
Ting Wu, Yingqi Zhao, Xin Zhang, Yuanhe Wang, Qiuchen Chen, Mingrong Zhang, Huan Sheng, Yuying Zhang, Jinyu Guo, Jun Li, Yuxuan Fan, Ziqing Wang, Yalun Li, Haoran Wang, Minjie Wei, Xiaoyun Hu, Huizhe Wu   +16 more
wiley   +1 more source

The Lrs14‐Like AbfR1 Homolog From Metallosphaera sedula Is a Nucleoid‐Organizing Protein

MicrobiologyOpen, Volume 14, Issue 5, October 2025.
Nucleoid organization in Crenarchaeota involves diverse small DNA‐binding proteins. The Lrs14‐type protein AbfR1 from Metallosphaera sedula binds nonsequence specifically across the genome and induces DNA condensation. These findings suggest a structural role for AbfR1Ms in chromatin architecture, functionally resembling bacterial nucleoid‐associated ...
Veerke De Kock, Ronnie Willaert, Yannick Gansemans, Filip Van Nieuwerburgh, Rani Baes, Eveline Peeters   +5 more
wiley   +1 more source

Structural alterations induced by ten disease-causing mutations of human dihydrolipoamide dehydrogenase analyzed by hydrogen/deuterium-exchange mass spectrometry: Implications for the structural basis of E3 deficiency

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2016
Pathogenic amino acid substitutions of the common E3 component (hE3) of the human alpha-ketoglutarate dehydrogenase and the pyruvate dehydrogenase complexes lead to severe metabolic diseases (E3 deficiency), which usually manifest themselves in cardiological and/or neurological symptoms and often cause premature death. To date, 14 disease-causing amino
Ambrus, Attila, Wang Junjie, Mizsei, Réka, Zámbó, Zsófia, Törőcsik, Beáta, Jordan Frank, Ádám-Vizi, Veronika   +6 more
openaire   +3 more sources

Acute Myocardial Infarction: Molecular Pathogenesis, Diagnosis, and Clinical Management

MedComm, Volume 6, Issue 10, October 2025.
Key pathogenic mechanisms in AMI. Oxidative stress and mitochondrial dysfunction induce ROS accumulation, while DAMPs‐PRRs interaction triggers inflammatory cascades. Programmed cell death pathways and epigenetic regulation collectively constitute the core components of AMI pathogenesis.
Mengmeng Zhu, Yiwen Li, Qian Xu, Wenting Wang, Yanfei Liu, Yue Liu   +5 more
wiley   +1 more source

Copper Homeostasis, Emerging Central Players in Cancer Immunotherapy

Journal of Cellular and Molecular Medicine, Volume 29, Issue 19, October 2025.
ABSTRACT Copper ions serve as multifunctional signalling molecules that are integral to various cellular processes in vivo, including cell proliferation, apoptosis and migration. The storage, transport and homeostatic regulation of intracellular copper are closely linked to mitochondrial function.
Chengxin Chen, Mengle Peng, Shuhong Liang, Chunwei Li, Lili Zhu, Yaqi Yang, Lifeng Li, Wenhua Xue   +7 more
wiley   +1 more source

Alternative NAD(P)H dehydrogenase and alternative oxidase: proposed physiological roles in animals [PDF]

, 2019
The electron transport systems in mitochondria of many organisms contain alternative respiratory enzymes distinct from those of the canonical respiratory system depicted in textbooks.
Gospodaryov, Dmytro V., McDonald, Allison   +1 more
core   +1 more source

The Unsolved Pathogenesis of Idiopathic Ketotic Hypoglycemia:Involvement of the Pyruvate Dehydrogenase Kinase Isoenzyme 4 Gene? [PDF]

, 2011
Background and aim Ketotic hypoglycemia (KH) is the most common cause of hypoglycemia in childhood, among non-diabetic children. KH is defined by episodes of hypoglycemia with high ketone levels in plasma and urine, provoked by periods of fasting, often ...
Cung, Th.
core  

A Korean Female Patient with Thiamine-responsive Pyruvate Dehydrogenase Complex Deficiency Due to a Novel Point Mutation (Y161C)in the PDHA1 Gene [PDF]

, 2006
Pyruvate dehydrogenase complex (PDHC) deficiency is mostly due to mutations in the X-linked E1α subunit gene (PDHA1). Some of the patients with PDHC deficiency showed clinical improvements with thiamine treatment. We report the results of biochemical and
Benelli, Di Rocco, Eun Ha Lee, Jin Soon Hwang, Kitamori, Kyung Hwa Ryu, Lissens, Marsac, Matsuda, Mi Sun Ahn, Naito, Naito, Naito, Naito, Robinson, Robinson, Saijo, Sheu, Sun Jun Kim, Sung Hwan Kim   +19 more
core   +3 more sources

Analysis of genetic mutations using a recombinant model of the mammalian pyruvate dehydrogenase complex [PDF]

, 2008
The human mitochondrial pyruvate dehydrogenase complex (PDC) is a vital metabolic assembly that controls the key committed step in aerobic carbohydrate utilisation and energy production and as such is responsible for overall glucose homeostasis in man ...
Singh, Geetanjali
core   +1 more source

Stronger inflammatory/cytotoxic T cell response in women identified by microarray analysis [PDF]

, 2008
Women develop chronic inflammatory autoimmune diseases like lupus more often than men. The mechanisms causing the increased susceptibility are incompletely understood, although estrogen is believed to contribute.
Anura Hewagama, Bruce C. Richardson, Dipak Patel, Faith M. Strickland, Sushma Yarlagadda   +4 more
core   +1 more source