Results 41 to 50 of about 3,435 (174)

The scaffolding protein JADE1 physically links the acetyltransferase subunit HBO1 with its histone H3–H4 substrate

Journal of Biological Chemistry, 2018
The human enzyme histone acetyltransferase binding to ORC1 (HBO1) regulates DNA replication, cell proliferation, and development. HBO1 is part of a multiprotein histone acetyltransferase (HAT) complex that also contains inhibitor of growth family member (
Joseph Han, C. Lachance, M. Ricketts, C. McCullough, Morgan Gerace, B. E. Black, J. Côté, R. Marmorstein   +7 more
semanticscholar   +1 more source

Antioxidant supplementation blunts the proteome response to 3 weeks of sprint interval training preferentially in human type 2 muscle fibres

The Journal of Physiology, EarlyView.
Abstract figure legend Sprint interval training (SIT) is a popular time‐efficient type of endurance training. Healthy young men performed nine SIT sessions (4–6 × 30 s all‐out cycling sprints) over 3 weeks while being supplemented with antioxidants (high doses of vitamins C and E) or placebo. Muscle biopsies taken before and after the first SIT session
Victoria L. Wyckelsma, Marta Murgia, Sigitas Kamandulis, Stefano Gastaldello, Marius Brazaitis, Audrius Snieckus, Nerijus Eimantas, Mati Pääsuke, Sebastian Edman, William Apro, Daniel C. Andersson, Håkan Westerblad, Tomas Venckunas   +12 more
wiley   +1 more source

A high‐fat diet impairs mitochondrial biogenesis, mitochondrial dynamics, and the respiratory chain complex in rat myocardial tissues

Journal of Cellular Biochemistry, Volume 119, Issue 11, Page 9602-9602, November 2018., 2018
Abstract A high‐fat diet (HFD) has been associated with heart failure and arrhythmias; however, the molecular mechanisms underlying these associations are poorly understood. The mitochondria play an essential role in optimal heart performance, most of the energy for which is obtained from the oxidation of fatty acids.
Dan Chen, Xia Li, LiTing Zhang, Mei Zhu, Ling Gao   +4 more
wiley   +1 more source

Residue Leu-641 of Acetyl-CoA Synthetase is Critical for the Acetylation of Residue Lys-609 by the Protein Acetyltransferase Enzyme of Salmonella enterica*

Journal of Biological Chemistry, 2005
Posttranslational regulation of protein function by acetylation is present throughout nature. Regulation of protein function by Sir2 protein (sirtuin) deacetylases is conserved in all domains of life.
V. Starai, Jeffrey G. Gardner, J. Escalante‐Semerena   +2 more
semanticscholar   +1 more source

The Isoquinoline Alkaloid Dauricine Targets Multiple Molecular Pathways to Ameliorate Alzheimer‐Like Pathological Changes In Vitro

Oxidative Medicine and Cellular Longevity, Volume 2018, Issue 1, 2018., 2018
Alzheimer’s disease (AD), the most common neurodegenerative disease, has no effective treatment. Dauricine (DAU), a benzyl tetrahydroisoquinoline alkaloid isolated from the root of Menispermum dauricum DC, reportedly has neuroprotective effects in cerebral ischemia.
Pan Liu, Xiao Chen, Haizhe Zhou, Liqun Wang, Zaijun Zhang, Xiaohu Ren, Feiqi Zhu, Yi Guo, Xinfeng Huang, Jianjun Liu, Peter S. Spencer, Xifei Yang, Lisbell Estrada   +12 more
wiley   +1 more source

The fungal‐specific histone acetyltransferase Rtt109 regulates development, DNA damage response, and virulence in Aspergillus fumigatus

Molecular Microbiology, 2020
In eukaryotes, histone acetylation catalyzed by histone acetyltransferase (HAT) has been demonstrated to be critical for various physiological processes.
Yuanwei Zhang, Jialu Fan, Jing Ye, Ling Lu   +3 more
semanticscholar   +1 more source

Integrated Analysis of Cuproptosis Regulators Reveals Prognostic Significance and Therapeutic Targets in IDH1 Mutant Glioma

MedComm – Future Medicine, Volume 4, Issue 1, March 2025.
This study performed a comprehensive analysis of cuproptosis‐related genes (CRGs) in IDH1‐mutant glioma samples from the TCGA database. Two novel IDH1‐mutant glioma subtypes were identified based on CRG expression patterns. FDX1 and SLC31A1 were identified as key regulators.
Yuxuan Luan, Yong Meng, Chunming Sun, Ruixin Wu, Qimeng Chang, Yilin Wang, Minfeng Shu   +6 more
wiley   +1 more source

iTRAQ‐Based Proteomics Analysis Reveals the Effect of Rhubarb in Rats with Ischemic Stroke

BioMed Research International, Volume 2018, Issue 1, 2018., 2018
Background. Rhubarb, a traditional Chinese medicine, promotes viscera and remove blood stasis. Rhubarb is skilled in smoothening meridians, improving blood circulation which exhibits better efficacy on cerebral ischemic stroke. In this study, we aimed to analyze the underlying mechanisms of rhubarb which treated rats of middle cerebral artery occlusion
Xiangping Lin, Tao Liu, Pengfei Li, Zehui He, Yuanyuan Zhong, Hanjin Cui, Jiekun Luo, Yang Wang, Tao Tang, Sushil K. Jha   +9 more
wiley   +1 more source

The effect of mucA allele on biofilm architecture and the biofilm-related proteomes [PDF]

, 2011
In this study, a unique mucA mutation (designated mucA56) was introduced, which was characterized by deletion of bases 166-333, encoding MucA56 protein with the deletion of the trans-membrane region, which then was proved to be cytoplasmic with phoA-mucA
Chen, Anqun, Mathee, Kalai, Tian, Deying, Xie, Linka   +3 more
core  

Data for proteomic analysis of murine cardiomyocytic HL1 cells treated with siRNA against tissue factor [PDF]

, 2015
YesThis data article is related to the research article entitled Proteomics of Tissue Factor silencing in cardiomyocytic cells reveals a new role for this coagulation factor in splicing machinery control by Lento et al [1]. Tissue Factor (TF) is the key
Cristina Banfi, Elena Tremoli, Maura Brioschi, Md. Talat Nasim, Sabrina Lento, Silvia Stella Barbieri, Simona Barcella, Stefania Ghilardi   +7 more
core   +2 more sources