Glia, Volume 72, Issue 7, Page 1319-1339, July 2024.Main Points Microglial cells in ALS develop highly proliferative phenotypes and lose their phagocytic capacity. Microglia molecular signature at protein level was characterized with a robust up‐regulation of several unconventional proteins including rootletin and STK38.
Romina Barreto‐Núñez +6 more
wiley +1 more source
The Elongator subunit Elp3 is a non-canonical tRNA acetyltransferase
Nature Communications, 2019 The Elongator complex catalyzes posttranscriptional tRNA modifications by attaching carboxy-methyl (cm5) moieties to uridine bases located in the wobble position.
Ting-Yu Lin +6 more
semanticscholar +1 more source
Global profiling of protein lactylation in Caenorhabditis elegans
PROTEOMICS, Volume 24, Issue 1-2, January 2024.Abstract Lactylation, as a novel posttranslational modification, is essential for studying the functions and regulation of proteins in physiological and pathological processes, as well as for gaining in‐depth knowledge on the occurrence and development of many diseases, including tumors. However, few studies have examined the protein lactylation of one
Tao Ding +8 more
wiley +1 more source
Exercise training impacts cardiac mitochondrial proteome remodeling in murine urothelial carcinoma [PDF]
, 2019 Cardiac dysfunction secondary to cancer may exert a negative impact in patients’ tolerance to therapeutics, quality of life, and survival. The aim of this study was to evaluate the potential therapeutic effect of exercise training on the heart in the ...
Aroso, M +9 more
core +1 more source
The pKa of the catalytic histidine residue of chloramphenicol acetyltransferase.
Biochemical Journal, 1993 A catalytically essential histidine residue (His-195) of chloramphenicol acetyltransferase (CAT) acts as a general base in catalysis, abstracting a proton from the primary hydroxy group of chloramphenicol.
A. Lewendon, W. V. Shaw
semanticscholar +1 more source
Rosistilla oblonga gen. nov., sp. nov. and Rosistilla carotiformis sp. nov., isolated from biotic or abiotic surfaces in Northern Germany, Mallorca, Spain and California, USA [PDF]
, 2020 Planctomycetes are ubiquitous bacteria with fascinating cell biological features. Strains available as axenic cultures in most cases have been isolated from aquatic environments and serve as a basis to study planctomycetal cell biology and interactions ...
Boedeker, Christian +11 more
core +2 more sources
An Investigation into the Cytotoxic Effects of 13-Acetoxysarcocrassolide from the Soft Coral Sarcophyton crassocaule on Bladder Cancer Cells [PDF]
, 2011 Active compounds from natural products have been widely studied. The anti-tumor effects of 13-acetoxysarcocrassolide isolated from Formosan soft coral Sarcophyton crassocaule on bladder cancer cells were examined in this study.
Ahmed +88 more
core +4 more sources
Phenotypic and transcriptomic analyses of seven clinical Stenotrophomonas maltophilia isolates identify a small set of shared and commonly regulated genes involved in the biofilm lifestyle [PDF]
, 2020 Stenotrophomonas maltophilia is one of the most frequently isolated multidrug-resistant nosocomial opportunistic pathogens. It contributes to disease progression in cystic fibrosis (CF) patients and is frequently isolated from wounds, infected tissues ...
Alio, Ifey +21 more
core +1 more source
PLoS ONE, 2018 Wood represents the most abundant biomass produced by plants and one of its major components is acetyl xylan. Acetylation in xylan can occur at O-2 or O-3 of a xylosyl residue, at both O-2 and O-3 of a xylosyl residue, and at O-3 of a xylosyl residue ...
R. Zhong, Dongtao Cui, Z. Ye
semanticscholar +1 more source
INVESTIGATION INTO THE CELLULAR ACTIONS OF CARNOSINE AND C-PEPTIDE [PDF]
, 2014 Carnosine is a dipeptide composed of beta-alanine and histidine found exclusively in long-lived animal tissues. The cellular action of carnosine is still under extensive investigation; however, it has been proposed to have a role as an anti-oxidant and ...
Gardner, Emma H.
core +1 more source