Polyamines regulate gene expression by stimulating translation of histone acetyltransferase mRNAs
Journal of Biological Chemistry, 2020 Polyamines regulate gene expression in Escherichia coli by translationally stimulating mRNAs encoding global transcription factors. In this study, we focused on histone acetylation, one of the mechanisms of epigenetic regulation of gene expression, to ...
A. Sakamoto +4 more
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Degradation of Serotonin N-Acetyltransferase, a Circadian Regulator, by the N-end Rule Pathway*
Journal of Biological Chemistry, 2016 Serotonin N-acetyltransferase (AANAT) converts serotonin to N-acetylserotonin (NAS), a distinct biological regulator and the immediate precursor of melatonin, a circulating hormone that influences circadian processes, including sleep.
B. Wadas +5 more
semanticscholar +1 more source
Lysine Acetyltransferase Inhibitors From Natural Sources
Frontiers in Pharmacology, 2020 Acetylation of histone and non-histone protein lysine residues has been widely described as a critical modulator of several cell functions in humans. Lysine acetyltransferases (KATs) catalyse the transfer of acetyl groups on substrate proteins and are ...
F. Fiorentino, A. Mai, D. Rotili
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Proteomic Analysis of Chinese Hamster Ovary Cells Producing Glycosylated Monoclonal Antibodies [PDF]
, 2013 Therapeutic monoclonal antibodies (MAb) are produced as secreted complex glycoproteins from mammalian cell systems and represent one of the most important classes of therapeutic medicines for the treatment of a variety of human diseases. Their benefit in
Ho, Raymond
core
Journal of Biological Chemistry, 2015 Background: PatZ is the main Escherichia coli acetyltransferase and controls acetyl-CoA synthetase (Acs) activity. Results: The kinetic and structural PatZ oligomer characteristics were determined.
T. de Diego Puente +7 more
semanticscholar +1 more source
Papel de la nueva familia de receptores endolisosomales de NAADP (TPCs) en la función cardiovascular y la fisiopatología del síndrome metabólico [PDF]
, 2016 Rationale: Autophagy participates in both physiological and pathological remodeling of the heart. The endolysosomal two-pore channels TPC1 and TPC2 have been implicated in the regulation of metabolism and autophagy.
García Rúa, Vanessa
core +1 more source
An in vitro model of murine middle ear epithelium. [PDF]
, 2016 Otitis media (OM) or middle ear inflammation is the most common pediatric disease and leads to significant morbidity. Although understanding of underlying disease mechanisms is hampered by complex pathophysiology it is clear that epithelial abnormalities
Admyre +73 more
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Lettuce (Lactuca sativa L.) leaf-proteome profiles after exposure to cylindrospermopsin and a microcystin-LR/cylindrospermopsin mixture: A concentration-dependent response [PDF]
, 2014 The intensification of agricultural productivity is an important challenge worldwide. However, environmental stressors can provide challenges to this intensification. The progressive occurrence of the cyanotoxins cylindrospermopsin (CYN) and microcystin-
Azevedo, Joana +6 more
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Journal of Biological Chemistry, 2018 Short-chain acylation of lysine residues has recently emerged as a group of reversible posttranslational modifications in mammalian cells. The diversity of acylation further broadens the landscape and complexity of the proteome.
Zhen Han +15 more
semanticscholar +1 more source
Cross-reactivity and sequence similarity between microbial transglutaminase and human tissue antigens. [PDF]
Sci Rep, 2023 Lerner A, Benzvi C, Vojdani A.
europepmc +1 more source