Results 141 to 150 of about 4,532 (195)
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(Trihalogenmethyl)dihydropyridine
Chemische Berichte, 1977Abstract1‐(2,6‐Dichlorbenzyl)‐ und 1‐Ethylpyridinium‐Salze ergeben mit Haloformat‐Anionen (Trihalogenmethyl)dihydropyridine. Je nach dem verwendeten Haloform werden primär nur die 1,2‐ oder die 1,4‐Dihydropyridine gebildet. Die 2‐(Trichlormethyl)‐1,2‐dihydropyridine 1 lagern sich in polaren, aprotischen Lösungsmitteln in die 4‐(Trichlormethyl)‐1,4 ...
Karl Heinz Duchardt, Fritz Kröhnke
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Synthesis of Spiro1,4–Dihydropyridines: A Review
Current Organic Synthesis, 2020The preparation of medicinally promising spiro1,4–dihydropyridines accompanied by their applications in biological and pharmaceutical activities is presented. Spiro1,4–dihydropyridines were synthesized using numerous reported methods including bronested acids such as p-TSA, AcOH, nano-ranged calix[4]arene tetracarboxylic acid, sulfamic acid, PEG ...
Zahra Sadri, Farahnaz K. Behbahani
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Dihydropyridines on guinea-pig ileum
General Pharmacology: The Vascular System, 19901. The effects of three dihydropyridine derivates were studied and compared with those of nifedipine in guinea-pig ileum. 2. Nifedipine, nimodipine, nitrendipine (25-200 nM) and nisoldipine (10-80 nM) produced a dose-dependent inhibition of the contractile responses induced by single pulse stimulation, acetylcholine (1 microM) and high-K (50 mM).
I, Martin +3 more
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Antihypertensive dihydropyridines with 1,4,4-trisubstitution
Journal of Medicinal Chemistry, 1990Dihydropyridines with 1,4,4-trisubstitution were synthesized and tested for antihypertensive activity in a spontaneously hypertensive rat model. This substitution pattern on the dihydropyridine nucleus differs markedly from that found most active in the structure-activity relationship established for nifedipine-like compounds.
M J, Kukla, H J, Breslin, A, Gill
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Antioxidant activity of different dihydropyridines
Biochemical and Biophysical Research Communications, 2003Lacidipine, a dihydropyridine-based calcium antagonist (DHP), has already been demonstrated to possess antioxidant activity and to reduce the intracellular production of reactive oxygen species (ROS). To verify if this effect is a peculiarity of this molecule, or belongs to other DHPs, the activity of lacidipine was compared with those of amlodipine ...
COMINACINI, Luciano +8 more
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Spatial Structure of Dihydropyridines and Similarity of Dihydropyridines with some Amino Acids
Molecular Engineering, 1997Semi-empirical (PM3) and ab-initio (PSGVB) calculations were carried out for 1,4-dihydropyridine (DHP) and various of its derivatives and also for related amino acids, in order to understand the conformational changes brought about by the substituents and the peptidomimetic properties of the DPH derivatives, in terms of the similarity of their spatial ...
Inta Liepina +3 more
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1,4-Dihydropyridines and the 1,4-Dihydropyridine Receptor
1993The 1,4-dihydropyridine nifedipine is a first-generation drug of major significance in the treatment of cardiovascular disorders including hypertension, peripheral vascular disorders and angina in its several forms. Nifedipine is one of a chemically and pharmacologically heterogeneous group of drugs that includes also verapamil and diltiazem and which ...
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Hantzsch dihydropyridine synthesis
20091,4-Dihydropyridine from the condensation of aldehyde, β-ketoester and ammonia. Hantzsch 1,4-dihydropyridines are popular reducing reagents in organo-catalysis.
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1985
The purpose of this chapter is to review some of the recent studies on the characterization of 1,4-dihydropyridine receptors (DHPRs). In this respect the chapter will complement the contributions of Glossmann, Nayler and Schwartz (this volume) and the previously published reviews of 1,4-dihydropyridine (DHP) binding studies (Meyer et al.
R. A. Janis +3 more
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The purpose of this chapter is to review some of the recent studies on the characterization of 1,4-dihydropyridine receptors (DHPRs). In this respect the chapter will complement the contributions of Glossmann, Nayler and Schwartz (this volume) and the previously published reviews of 1,4-dihydropyridine (DHP) binding studies (Meyer et al.
R. A. Janis +3 more
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Optimization of diastereomeric dihydropyridines as antimalarials
European Journal of Medicinal ChemistryThe increase in research funding for the development of antimalarials since 2000 has led to a surge of new chemotypes with potent antimalarial activity. High-throughput screens have delivered several thousand new active compounds in several hundred series, including the 4,7-diphenyl-1,4,5,6,7,8-hexahydroquinolines, hereafter termed dihydropyridines ...
Kurt S. Van Horn +21 more
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