Results 121 to 130 of about 14,833,612 (178)

Dihydrotanshinone I improves cardiac function by promoting lymphangiogenesis after myocardial ischemia-reperfusion injury.

European Journal of Pharmacology
Dihydrotanshinone I (DHT) is an active ingredient derived from Salvia miltiorrhiza. Previous studies have demonstrated that DHT can improve cardiac function in rats with myocardial ischemia-reperfusion injury (IR).
Ya-Chao Wang, Yan Zhu, Wanf Meng, Yan Zheng, Xiao-qi Guan, Chang-le Shao, Xiu-ya Li, Dan Hu, Ming-zhu Wang, Hai-dong Guo   +9 more
semanticscholar   +3 more sources

Nano co-delivery of Plumbagin and Dihydrotanshinone I reverses immunosuppressive TME of liver cancer.

Journal of Controlled Release, 2022
Hepatocellular carcinoma (HCC) is resistant to current immunotherapy. This poor outcome mainly results from the immunosuppressive characteristics of tumor microenvironment (TME).
Shulan Han, Shengnan Bi, Tingting Guo, Dandan Sun, Yifang Zou, Lingzhi Wang, Liu Song, Dinh-Toi Chu, Anqi Liao, Xiaohuan Song, Zhuo Yu, Jianfeng Guo   +11 more
semanticscholar   +3 more sources

Dihydrotanshinone I Attenuates Diet‐Induced Nonalcoholic Fatty Liver Disease via Up‐Regulation of IRG1

Phytotherapy Research
Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease, but effective therapeutic drugs are still lacking. Dihydrotanshinone I (DHTS), a natural product isolated from Salvia miltiorrhiza , has been shown to have ameliorative ...
Yang Xiang, Ge Kuang, X. Gong, Huang Xie, Yan Lin, Xijian Zhang, Zhongpei Chen, Jingyuan Wan, Zhenhan Li   +8 more
semanticscholar   +3 more sources

Dihydrotanshinone I reduces H9c2 cell damage by regulating AKT and MAPK signaling pathways

In Vitro Cellular & Developmental Biology - Animal
Cardiovascular disease is the deadliest disease in the world. Previous studies have shown that Dihydrotanshinone I (DHT) can improve cardiac function after myocardial injury. This study aimed to observe the protective effect and mechanism of DHT on H9c2 cells by establishing an oxygen-glucose deprivation/reoxygenation (OGD/R) injury model.
Ya-Chao Wang, Y. Shao, Chang-le Shao, Xiao-qi Guan, Ping-ping Lu, Ke Ning, Bao-nian Liu, Hai-dong Guo   +7 more
semanticscholar   +3 more sources

Biological activity of dihydrotanshinone I: Effect on apoptosis

Journal of Bioscience and Bioengineering, 2000
Recently, we have found for the first time that dihydrotanshinone I, isolated from Salvia miltiorrhiza, exhibited cytotoxicity against various tumor cell lines. To investigate whether the mechanism underlying dihydrotanshinone I toxicity involved apoptosis in cancer cell lines, we examined cell growth arrest and cell death by flow cytometric analysis ...
D S, Lee, S H, Lee
openaire   +2 more sources

Dihydrotanshinone I inhibits the growth of hepatoma cells by direct inhibition of Src

Phytomedicine, 2022
Liver cancer is one of the leading causes of cancer-related death worldwide. Dihydrotanshinone I (DHI) was shown to inhibit the growth of several types of cancer. However, research related to hepatoma treatment using DHI is limited.Here, we explored the inhibitory effect of DHI on the growth of hepatoma cells, and investigated the underlying molecular ...
Xiao-Li, Jiang, Bo, Deng, Sui-Hui, Deng, Min, Cai, Wen-Jun, Ding, Zhang-Bin, Tan, Rui-Xue, Chen, You-Cai, Xu, Hong-Lin, Xu, Shuang-Wei, Zhang, Shi-Qing, Zhang, Bin, Liu, Jing-Zhi, Zhang   +12 more
openaire   +2 more sources

Dihydrotanshinone I inhibits the translational expression of hypoxia-inducible factor-1α

Chemico-Biological Interactions, 2015
The hypoxia-inducible factor-1 (HIF-1) has been known to be correlated to the adaptation and proliferation of tumor cells; therefore HIF-1 has become an important target in the development of anticancer drugs. Dihydrotanshinone I (DHTS) is a phenanthrenequinone compound from Salvia miltiorrhiza Bunge, which has been used in oriental medicine for its ...
Jing, Li, Chunliu, Mi, Juan, Ma, Ke Si, Wang, Jung Joon, Lee, Xuejun, Jin   +5 more
openaire   +2 more sources

15, 16-Dihydrotanshinone I protects against ischemic stroke by inhibiting ferroptosis via the activation of nuclear factor erythroid 2-related factor 2.

Phytomedicine, 2023
BACKGROUND Nuclear factor erythroid 2-related factor 2 (Nrf2) is a key regulator of antioxidative stress responses, which are associated with ferroptosis inhibition. Ferroptosis is closely related to the pathophysiological process of ischemic stroke. 15,
Chuanhong Wu, Feipeng Duan, Ruocong Yang, Yaolan Dai, Xiuping Chen, Shaojing Li   +5 more
semanticscholar   +1 more source

Hepatic Stellate Cell- and Liver Microbiome-Specific Delivery System for Dihydrotanshinone I to Ameliorate Liver Fibrosis.

ACS Nano, 2023
Liver fibrosis is a major contributor to the morbidity and mortality associated with liver diseases, yet effective treatment options remain limited. Hepatic stellate cells (HSCs) are a promising target for hepatic fibrogenesis due to their pivotal role ...
Xia Niu, Yanan Meng, Jinjin Cui, Rui Li, Xiao Ding, Bingyu Niu, Ge Chang, Ning Xu, Guiling Li, Yucheng Wang, Lulu Wang   +10 more
semanticscholar   +1 more source

Dihydrotanshinone I attenuates estrogen-deficiency bone loss through RANKL-stimulated NF-κB, ERK and NFATc1 signaling pathways.

International Immunopharmacology, 2023
Postmenopausal osteoporosis, a chronic condition that predominantly affects postmenopausal women, presents a significant impediment to their overall well-being.
Chao Ma, Liang Mo, Zhang-Yu Wang, Deqiang Peng, Chi Zhou, Wei Niu, Yuhao Liu, Zhenqiu Chen   +7 more
semanticscholar   +1 more source