Results 131 to 140 of about 14,833,612 (178)
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Free Radical Biology & Medicine, 2022
Dihydrotanshinone I (DHT), a bioactive compound in Salvia miltiorrhiza, was reported to exhibit cytotoxicity against various malignancies. However, the underlying mechanism on ovarian cancer remains unclear.
Chengtao Sun +9 more
semanticscholar +1 more source
Dihydrotanshinone I (DHT), a bioactive compound in Salvia miltiorrhiza, was reported to exhibit cytotoxicity against various malignancies. However, the underlying mechanism on ovarian cancer remains unclear.
Chengtao Sun +9 more
semanticscholar +1 more source
Phytomedicine, 2015
Dihydrotanshinone I (DHTS) was previously reported to exhibit the most potent anti-cancer activity among several tanshinones in colon cancer cells. Its cytotoxic action was reactive oxygen species (ROS) dependent but p53 independent.To further study the anti-cancer activity of DHTS and its molecular mechanisms of action in colon cancer both in vitro ...
Lin, Wang +8 more
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Dihydrotanshinone I (DHTS) was previously reported to exhibit the most potent anti-cancer activity among several tanshinones in colon cancer cells. Its cytotoxic action was reactive oxygen species (ROS) dependent but p53 independent.To further study the anti-cancer activity of DHTS and its molecular mechanisms of action in colon cancer both in vitro ...
Lin, Wang +8 more
openaire +2 more sources
Pharmacology, 2020
<b><i>Introduction:</i></b> The plaques formed by amyloid-β (Aβ) accumulation and neurofibrillary tangles formed by hyper-phosphorylated tau protein are the 2 major pathologies of Alzheimer’s disease (AD). Recently, autophagy is considered to be a self-degradation process of preserved cytoplasmic abnormal substances, including ...
Zhonglei, Bao +5 more
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<b><i>Introduction:</i></b> The plaques formed by amyloid-β (Aβ) accumulation and neurofibrillary tangles formed by hyper-phosphorylated tau protein are the 2 major pathologies of Alzheimer’s disease (AD). Recently, autophagy is considered to be a self-degradation process of preserved cytoplasmic abnormal substances, including ...
Zhonglei, Bao +5 more
openaire +2 more sources
Bioscience, Biotechnology, and Biochemistry, 1999
Cryptotanshinone and dihydrotanshinone I, constituents of a medicinal plant, Salvia miltiorrhiza Bunge, had antibacterial activity against a broad range of Gram positive bacteria. These compounds generated superoxide radicals in Bacillus subtilis lysates. A recombination-deficient mutant strain of B. subtilis was 2- to 8-fold more sensitive than a wild
D S, Lee, S H, Lee, J G, Noh, S D, Hong
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Cryptotanshinone and dihydrotanshinone I, constituents of a medicinal plant, Salvia miltiorrhiza Bunge, had antibacterial activity against a broad range of Gram positive bacteria. These compounds generated superoxide radicals in Bacillus subtilis lysates. A recombination-deficient mutant strain of B. subtilis was 2- to 8-fold more sensitive than a wild
D S, Lee, S H, Lee, J G, Noh, S D, Hong
openaire +2 more sources
European Journal of Pharmacology
Lung cancer represents one of the most lethal malignancies, characterized by the highest incidence and mortality rates globally. Cisplatin-based chemotherapy exerts powerful anti-tumor activities in lung cancer, whereas its clinical application was ...
Haizhen Lin +9 more
semanticscholar +1 more source
Lung cancer represents one of the most lethal malignancies, characterized by the highest incidence and mortality rates globally. Cisplatin-based chemotherapy exerts powerful anti-tumor activities in lung cancer, whereas its clinical application was ...
Haizhen Lin +9 more
semanticscholar +1 more source
Toxicology Letters, 2023
Our previous study found that high-dose Tanshinones Capsule (TC) aggravated cholestasis in mice. To explore its underlying mechanism, main tanshinones components (15,16-dihydrotanshinone I (DTI), cryptotanshinone (CTS) and tanshinone IIA (TSA)) form TC ...
Yue Li +9 more
semanticscholar +1 more source
Our previous study found that high-dose Tanshinones Capsule (TC) aggravated cholestasis in mice. To explore its underlying mechanism, main tanshinones components (15,16-dihydrotanshinone I (DTI), cryptotanshinone (CTS) and tanshinone IIA (TSA)) form TC ...
Yue Li +9 more
semanticscholar +1 more source
Antioxidants & Redox Signaling, 2021
Aims: Vulnerable plaque disruption in advanced atherosclerosis leads to acute thrombus and subsequent myocardial infarction and severely threatens human health. Necroptosis of macrophage involved in the necrotic core is one key factor for plaque vulnerability.
Wenwen, Zhao +6 more
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Aims: Vulnerable plaque disruption in advanced atherosclerosis leads to acute thrombus and subsequent myocardial infarction and severely threatens human health. Necroptosis of macrophage involved in the necrotic core is one key factor for plaque vulnerability.
Wenwen, Zhao +6 more
openaire +2 more sources
Phytomedicine
BACKGROUND Ovarian cancer is a major lethal malignancy of the female reproductive system. Dihydrotanshinone I (DHT) is a tanshinone compound derived from Salvia miltiorrhiza and possesses significant anti-ovarian cancer activity.
Bing Han +11 more
semanticscholar +1 more source
BACKGROUND Ovarian cancer is a major lethal malignancy of the female reproductive system. Dihydrotanshinone I (DHT) is a tanshinone compound derived from Salvia miltiorrhiza and possesses significant anti-ovarian cancer activity.
Bing Han +11 more
semanticscholar +1 more source
Toxicology and Applied Pharmacology, 2018
Ulcerative colitis (UC) is a chronic and relapsing inflammatory disorder of the colon and rectum with increasing morbidity in recent years. 15,16-dihydrotanshinone Ӏ (DHT) is a natural product with multiple bioactivities. In this study, we aimed to investigate the protective effect and potential mechanisms of DHT on UC. Dextran sulfate sodium salt (DSS)
Yanling Guo +5 more
openaire +2 more sources
Ulcerative colitis (UC) is a chronic and relapsing inflammatory disorder of the colon and rectum with increasing morbidity in recent years. 15,16-dihydrotanshinone Ӏ (DHT) is a natural product with multiple bioactivities. In this study, we aimed to investigate the protective effect and potential mechanisms of DHT on UC. Dextran sulfate sodium salt (DSS)
Yanling Guo +5 more
openaire +2 more sources
Phytomedicine
BACKGROUND Despite progress made in addressing the COVID-19 pandemic, numerous challenges persist, including breakthrough infections (BTI) and reinfections with SARS-CoV-2.
Chan Yang +13 more
semanticscholar +1 more source
BACKGROUND Despite progress made in addressing the COVID-19 pandemic, numerous challenges persist, including breakthrough infections (BTI) and reinfections with SARS-CoV-2.
Chan Yang +13 more
semanticscholar +1 more source