Results 141 to 150 of about 14,833,612 (178)

The CCR5/ROS/NRF2 axis Mediates Dihydrotanshinone I-Induced oxidative stress and apoptosis in hepatocellular carcinoma.

Biochemical Pharmacology
Despite therapeutic advances, hepatocellular carcinoma (HCC) remains a leading cause of cancer mortality worldwide. While dihydrotanshinone I (DHT) shows promising anticancer potential, its molecular mechanisms in HCC remain unexplored. Here, we unveil a
Ruoxin Tu, Yining Wang, Ru Xu, Shusheng Wang, Jiabin Cai, Lin Sun, Pengfei Gao   +6 more
semanticscholar   +1 more source

Identification of dihydrotanshinone I as an ERp57 inhibitor with anti-breast cancer properties via the UPR pathway.

Biochemical Pharmacology, 2021
Salvia miltiorrhiza (Danshen) is a well-known traditional Chinese medicine for treating various diseases, such as breast cancer. However, knowledge regarding its mechanisms is scant.
Wei Shi, Han Han, Jia Zou, Ying Zhang, Haitao Li, Hefeng Zhou, G. Cui   +6 more
semanticscholar   +1 more source

Dihydrotanshinone I, a main compound of Salvia miltiorrhiza, alleviates autoimmune and inflammatory diseases by directly targeting IRF3.

Phytomedicine
BACKGROUND Interferon regulatory factor 3 (IRF3) is an essential component of the immune system to protect the host from aggression, but excessive IRF3 activation leads to the release of type I interferon, interferon-stimulated genes (ISGs) and pro ...
Wei Shi, Jincai Wen, Yuan Gao, Tingting Liu, Hui Li, Huijie Yang, Jia Zhao, Ziying Wei, Chengwei Li, Qing Yao, Xiaohe Xiao, Zhaofang Bai   +11 more
semanticscholar   +1 more source

[Dihydrotanshinone I (DHTS1) attenuates cuprizone-induced demyelination via regulating microglia polarization].

Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology, 2020
Objective To evaluate whether dihydrotanshinone I (DHTS1) attenuates cuprizone-induced demyelination. Methods DHTS1 was dissolved in 5 g/L sodium carboxymethyl cellulose (CMC-Na). The cuprizone model was induced via feeding with the diet containing 2 g/L cuprizone. We administrated DHTS1 to the cuprizone-exposed mice.
Fang, Xu, Xiaojuan, Zhang, Xiaoqin, Liu, Wei, Zhang, Xiaolan, She, Xiuhua, Xue, Jiang, Bian, Minfang, Guo, Jiezhong, Yu, Cungen, Ma, Yanhua, Li   +10 more
openaire   +1 more source

Biophysical and molecular characterization of HuR inhibitors, CMLD-2 and Dihydrotanshinone I (DHTS), in Triple Negative Breast Cancer (TNBC).

International Journal of Biological Macromolecules
In the present study, we explored the oncogenic role of Human Antigen R (HuR), a post-transcriptional regulator implicated in cancer progression, metastasis, and therapy resistance.
Arundhathi J R Dev, Lakshay Malhotra, Akanksha Kashyap, Sheikh Umar, Meetu Rathee, Swarnava Samanta, Rahul Kharkwal, Debarka Sengupta, C. Prasad   +8 more
semanticscholar   +1 more source

Cryptotanshinone and dihydrotanshinone I exhibit strong inhibition towards human liver microsome (HLM)-catalyzed propofol glucuronidation

Fitoterapia, 2013
Danshen is one of the most famous herbs in the world, and more and more danshen-prescribed drugs interactions have been reported in recent years. Evaluation of inhibition potential of danshen's major ingredients towards UDP-glucuronosyltransferases (UGTs) will be helpful for understanding detailed mechanisms for danshen-drugs interaction.
Ming, Cong, Cui-Min, Hu, Yun-Feng, Cao, Zhong-Ze, Fang, Shu-Hong, Tang, Jia-Rui, Wang, Jun-Sheng, Luo   +6 more
openaire   +2 more sources

Dihydrotanshinone I: A Target for STAT3 in the Therapy of Tamoxifen‐Resistant Breast Cancer

ChemistrySelect, 2022
Abstract Breast cancer is the most prevalent tumour in women. Over two‐thirds of breast cancers are estrogen receptor (ER)‐positive breast cancers. These breast cancer patients are prone to tamoxifen resistance during breast cancer treatment.
Guanqun Wo, Zhen Zhu, Zheng Fang, Xi Chen, Mingxing Liang, Yalin Wang, Xinyi Shao, Hongyu Shen, Jin‐Hai Tang   +8 more
openaire   +1 more source

ALOX15-Driven Ferroptosis: The key target in Dihydrotanshinone I's epigenetic Battle in hepatic stellate cells against liver fibrosis.

International Immunopharmacology
BACKGROUND It is known that ferroptosis promotes hepatic stellate cells (HSCs) inactivation. Arachidonate 15-Lipoxygenase (ALOX15), a ferroptosis driver gene, participates in disease progression.
Ningzhe Shen, Mengyuan Li, Binbo Fang, Xinmiao Li, Feng Jiang, Tingdi Zhu, Jianjian Zheng, Weizhi Zhang   +7 more
semanticscholar   +1 more source

Dihydrotanshinone I induces necroptosis and cell cycle arrest in gastric cancer through the PTPN11/p38 pathway.

Toxicology in Vitro
In this study, MTT assays, apoptosis detection, immunofluorescence, and functional studies were used to elucidate the mechanisms underlying the effects of dihydrotanshinone I (DHT) on gastric cancer cells.
Aizhen Li, Mingjin Yang, Wenbiao Duan, Bo Wu   +3 more
semanticscholar   +1 more source

Dihydrotanshinone I targets ESR1 to induce DNA double-strand breaks and proliferation inhibition in hepatocellular carcinoma.

Phytomedicine
BACKGROUND Due to its high incidence and elevated mortality, hepatocellular carcinoma (HCC) has emerged as a formidable global healthcare challenge. The intricate interplay between gender-specific disparities in both incidence and clinical outcomes has ...
Yunmeng Nie, Junbin Yan, Xueru Huang, Tao Jiang, Shuo Zhang, Guangji Zhang   +5 more
semanticscholar   +1 more source