Results 21 to 30 of about 14,833,612 (178)

Dihydrotanshinone I Inhibits the Growth of Osteosarcoma Through the Wnt/β-Catenin Signaling Pathway [Retraction]. [PDF]

Onco Targets Ther, 2023
Tan T, Chen J, Hu Y, et al. Onco Targets Ther. 2019;12:5111–5122. The Editor and Publisher of OncoTargets and Therapy are retracting the published article. Concerns were raised regarding image duplication in Figure 2. Specifically, The image for Figure 2E, 143B, Control, has been duplicated with the same image for Figure 2E, 143B, 0& ...
Tan,Tao, Chen,Jin, Hu,Yaxin, Wang,Nan, Chen,Yangmei, Yu,Tingting, Lin,Duanyang, Yang,Shengdong, Luo,Jinyong, Luo,Xiaoji   +9 more
europepmc   +3 more sources

The multifaceted mechanisms of Dihydrotanshinone I in the treatment of tumors.

Biomedicine & Pharmacotherapy
The morbidity and mortality of malignant tumors are progressively rising on an annual basis. Traditional Chinese Medicine (TCM) holds promise as a possible therapeutic agent for the avoidance or therapy of malignant tumors.
J. Yue, Dingqian Hao, Yingzheng Wang, Jinhao Guo, Shengyang Liu, Linghui Meng, Jianliang Liu   +6 more
semanticscholar   +3 more sources

Dihydrotanshinone-I modulates Epithelial Mesenchymal Transition (EMT) Thereby Impairing Migration and Clonogenicity of Triple Negative Breast Cancer Cells. [PDF]

Asian Pac J Cancer Prev, 2021
Background: Salvia miltiorrhiza Bunge (Danshen), has been used for its therapeutic value in Traditional Chinese Medicine (TCM), for almost a thousand years.
Kashyap A, Umar SM, Dev J R A, Prasad CP.   +3 more
europepmc   +2 more sources

TFEB-NF-κB inflammatory signaling axis: a novel therapeutic pathway of Dihydrotanshinone I in doxorubicin-induced cardiotoxicity. [PDF]

J Exp Clin Cancer Res, 2020
Background Doxorubicin is effective in a variety of solid and hematological malignancies. Unfortunately, clinical application of doxorubicin is limited due to a cumulative dose-dependent cardiotoxicity. Dihydrotanshinone I (DHT) is a natural product from
Wang X, Wang Q, Li W, Zhang Q, Jiang Y, Guo D, Sun X, Lu W, Li C, Wang Y.   +9 more
europepmc   +2 more sources

Activated PKB/GSK-3β synergizes with PKC-δ signaling in attenuating myocardial ischemia/reperfusion injury via potentiation of NRF2 activity: Therapeutic efficacy of dihydrotanshinone-I. [PDF]

Acta Pharm Sin B, 2021
Disrupted redox status primarily contributes to myocardial ischemia/reperfusion injury (MIRI). NRF2, the endogenous antioxidant regulator, might provide therapeutic benefits.
Zeng H, Wang L, Zhang J, Pan T, Yu Y, Lu J, Zhou P, Yang H, Li P.   +8 more
europepmc   +2 more sources

Dihydrotanshinone I inhibits ovarian cancer cell proliferation and migration by transcriptional repression of PIK3CA gene. [PDF]

J Cell Mol Med, 2020
AbstractDihydrotanshinone I (DHTS), extracted from Salvia miltiorrhiza, was found to be the most effective compound of tanshen extracts against cancer cells in our previous studies. However, the therapeutic benefits and underlying mechanisms of DHTS on ovarian cancer remain uncertain.
Wang X, Xu X, Jiang G, Zhang C, Liu L, Kang J, Wang J, Owusu L, Zhou L, Zhang L, Li W.   +10 more
europepmc   +3 more sources

15,16-Dihydrotanshinone I inhibits the proliferation of MV4-11 by means of apoptosis via antagonizing FLT3-ITD/STAT5/Mcl-1 pathway [PDF]

Bangladesh Journal of Pharmacology, 2023
Till now, the medicines approved for acute myeloid leukemia with internal tandem duplication mutation of FMS-like tyrosine kinase 3 (FLT3-ITD) display not ideal efficacy.
Mansheng Luo, Xiaoling Deng, Yanmei Zeng   +2 more
core   +3 more sources

Chromosome Doubling-Enhanced Biomass and Dihydrotanshinone I Production in Salvia miltiorrhiza, A Traditional Chinese Medicinal Plant. [PDF]

Molecules, 2018
The root of Chinese sage (Salvia miltiorrhiza Bunge) was regarded as top-grade Chinese medicine two thousand years ago, according to Shen Nong Materia Medica. The aim of this study is to develop an easy and reliable means for obtaining tetraploids (4x plants) via thidiazuron-induced direct organogenesis in the presence of colchicine.
Chen EG, Tsai KL, Chung HH, Chen JT.
europepmc   +5 more sources

Pharmacological activities of dihydrotanshinone I, a natural product from Salvia miltiorrhiza Bunge.

Pharmacological Research, 2019
Salvia miltiorrhiza Bunge (Danshen), a famous traditional Chinese herb, has been used clinically for the treatment of various diseases for centuries.
Xiuping Chen, Jie Yu, Bingling Zhong, Jiahong Lu, Jin-jian Lu, Shaojing Li, Yang Lu   +6 more
semanticscholar   +3 more sources

Dihydrotanshinone I promotes LDL uptake by HepG2 cells through increasing LDLR level

CyTA - Journal of Food
Dihydrotanshinone I (DHT), a lipophilic compound extracted from Salvia miltiorrhiza, has cardiovascular protective effects, but the underlying molecular mechanisms of action have rarely been reported.
Dandan Hu, Lin Qi, Litian Wang, Ya-Min Jin, Xiang-Xuan Yang, Huai-Liu Yin, Ren Zhang, Ye-wei Huang, Jun Sheng, Xuan-jun Wang   +9 more
semanticscholar   +3 more sources