Dihydrotanshinone I inhibits the growth of osteosarcoma through the Wnt/β-catenin signaling pathway.
Onco Targets Ther, 2019 Background: Osteosarcoma is a common malignant tumor, with relatively lower survival rates in adolescents. Dihydrotanshinone I (DHI) was extracted from the traditional Chinese medicine Salvia miltiorrhiza and was shown to inhibit several types of cancer.
Tan T +9 more
europepmc +4 more sources
Structures of human acetylcholinesterase bound to dihydrotanshinone I and territrem B show peripheral site flexibility. [PDF]
ACS Med Chem Lett, 2013 Acetylcholinesterase is a critical enzyme that regulates neurotransmission by degrading the neurotransmitter acetylcholine in synapses of the nervous system. It is an important target for both therapeutic drugs that treat Alzheimer's disease and chemical warfare agents that cripple the nervous system and cause death through paralysis.
Cheung J +3 more
europepmc +4 more sources
Dihydrotanshinone-I interferes with the RNA-binding activity of HuR affecting its post-transcriptional function. [PDF]
Sci Rep, 2015 AbstractPost-transcriptional regulation is an essential determinant of gene expression programs in physiological and pathological conditions. HuR is a RNA-binding protein that orchestrates the stabilization and translation of mRNAs, critical in inflammation and tumor progression, including tumor necrosis factor-alpha (TNF).
D'Agostino VG +11 more
europepmc +7 more sources
Antibacterial Mechanism of Dihydrotanshinone I
Natural Product Communications, 2021 The antimicrobial activity and the underlying action mechanisms of dihydrotanshinone I against Staphylococcus aureus, methicillin-resistant Staphylococcus aureus, extended-spectrum beta-lactamases Staphylococcus aureus were investigated with Kleihauer-Betke (K-B) test. The antibacterial mechanisms of dihydrotanshinone I were investigated by monitoring
Lin Zhao +5 more
openaire +1 more source
Cytotoxic diterpenoids from Salvia glutinosa and comparison with the tanshinone profile of danshen (Salvia miltiorrhiza) [PDF]
, 2023 The roots of Salvia miltiorrhiza are the source of the traditional Chinese medicine danshen and the class of tanshinones, particular quinoid nor-diterpenoids of the abietane type.
Ayvazyan, Arpine +4 more
core +4 more sources
Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of Nsp3 papain-like protease [PDF]
, 2021 The COVID-19 pandemic has emerged as the biggest life-threatening disease of this century. Whilst vaccination should provide a long-term solution, this is pitted against the constant threat of mutations in the virus rendering the current vaccines less ...
Armstrong, Lee A. +18 more
core +2 more sources
Comparison of the Inhibitory Potential of Bavachalcone and Corylin against UDP-Glucuronosyltransferases [PDF]
, 2014 Bavachalcone and corylin are two major bioactive compounds isolated from Psoralea corylifolia L., which has been widely used as traditional Chinese medicine for many years.
Feng, Yujun +8 more
core +7 more sources
Combining Metabolomics and Transcriptomics to Characterize Tanshinone Biosynthesis in Salvia Miltiorrhiza [PDF]
, 2014 Plant natural products have been co-opted for millennia by humans for various uses such as flavor, fragrances, and medicines. These compounds often are only produced in relatively low amounts and are difficult to chemically synthesize, limiting access ...
Cui, Guanghong +12 more
core +3 more sources
Endophyte Chaetomium globosum D38 Promotes Bioactive Constituents Accumulation and Root Production in Salvia miltiorrhiza [PDF]
, 2018 Salvia miltiorrhiza is known for tanshinones and salvianolic acids, which have been shown to have a protective effect against ROS, especially for cardiovascular diseases and other various ailments of human organs.
Han, T +9 more
core +3 more sources
Medicinal plants with anti-SARS-CoV activity repurposing for treatment of COVID-19 infection: A systematic review and meta-analysis [PDF]
, 2022 The novel SARS-CoV-2 (severe acute respiratory syndrome coronavirus) has emerged as a significant threat to public health with startling drawbacks in all sectors globally.
AWOLADE, PAUL +5 more
core +2 more sources