Results 41 to 50 of about 14,833,612 (178)

Interfering with HuR-RNA Interaction: Design, Synthesis and Biological Characterization of Tanshinone Mimics as Novel, Effective HuR Inhibitors [PDF]

, 2018
The human antigen R (HuR) is an RNA-binding protein known to modulate the expression of target mRNA coding for proteins involved in inflammation, tumorigenesis, and stress responses and is a valuable drug target.
Baj, Vanessa, Biasini, Emiliano, Bonomo, Isabelle, Brambilla, Marta, Cerofolini, Linda, D'Agostino, Vito G, Elezgarai, Saioa, Fragai, Marco, Lal, Preet, Luchinat, Claudio, Maio, Danilo Di, Manzoni, Leonardo, Marinelli, Luciana, Miceli, Marco, Novellino, Ettore, Provenzani, Alessandro, Seneci, Pierfausto, Thongon, Natthakan, Zucal, Chiara   +18 more
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Inhibition of DNA Topoisomerase I by Dihydrotanshinone I, Components of a Medicinal HerbSalvia miltiorrhizaBunge [PDF]

Bioscience, Biotechnology, and Biochemistry, 1999
Dihydrotanshinone I induced topoisomerase I-mediated DNA cleavage in vitro as strongly as camptothecin, but topoisomerase II-mediated DNA cleavage was not affected. In a DNA relaxation assay using calf thymus DNA topoisomerase I and supercoiled pBR322 plasmid DNA, dihydrotanshinone I reduced topoisomerase I-mediated DNA relaxation in a dose-dependent ...
D S, Lee, S H, Lee, G S, Kwon, H K, Lee, J H, Woo, J G, Kim, S D, Hong   +6 more
openaire   +2 more sources

Counter-current chromatography for the separation of terpenoids: A comprehensive review with respect to the solvent systems employed [PDF]

, 2014
Copyright @ 2014 The Authors.This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.Natural ...
A Berthod, A Berthod, A Koch, A Li, A Marston, A Maurya, A Peng, A Sun, ALM Nasser, AM Martin, AS Engelberth, AS Graham, B Diallo, B Diallo, B Medhi, B Pinel, BCB dos Santos, BK Gosse, C Zhao, CR Cheng, D Agostinho, D Du, D Fisher, D Grancher, D Wang, D Wang, D Wu, D Zhao, E Mudge, F Chen, F Chen, F Chen, F Fullas, F Gutiérrez, F He, F Oka, F Qiu, F Xiang, F Yang, G Tian, G Tian, G Wang, G Yan, GD Brown, GG Rocha, H Knapp, H Wu, H Ye, H Ye, H Zhang, HB Li, HB Li, HB Li, HB Li, HT Lu, I Slacanin, IA Sutherland, IA Sutherland, IA Sutherland, Ian Garrard, IJ Garrard, IJ Garrard, IJ Garrard, IJ Ha, J Hu, J Huang, J Liang, J Liu, J Ma, J Peng, J Wang, J Wang, J Wang, J Xie, J Xie, J Xu, J Yan, JCT Silva, JH Lee, JP Fan, JT Fischedick, JT Fischedick, JT Fischedick, K Skalicka-Woźniak, KD Yoon, KD Yoon, Krystyna Skalicka-Woźniak, KY Yoo, M Gu, M Gu, M Hamzaoui, M Lechtenberg, M Liu, M Puertas Mejia, MP Gasper, N Acton, N Fischer, N Frighetto, O Shehzad, O Shehzad, O Shehzad, O Shirota, O Shirota, P Hewitson, PA Souza De, PK Ajikumar, Q Chen, Q Du, Q Du, Q Du, Q Du, Q Du, Q Du, Q Du, QB Han, QB Han, QB Han, R Aman, R Graziose, R Roscher, R Tsao, RTS Frighetto, S Baldermann, S Baldermann, S He, S Liu, S Shi, S Wu, S Wu, S Yao, S Yao, SM Kim, SS Cicek, SY Shi, T Abbott, VF Rodrigues, VGP Severino, VP da Silva, W He, X Cao, X Han, X Qi, X Shi, X Xiao, X Xin, XC Li, XH Xiao, XY Huang, Y Cheng, Y Cheng, Y Geng, Y Ikai, Y Ito, Y Ito, Y Ito, Y Ito, Y Jiang, Y Lu, Y Lu, Y Ma, Y Wang, Y Wei, Y Wei, Y Wei, Y Yang, Y Yang, Y Yuan, Y Zhang, Y Zhao, YW Ha, YW Ha, YY Dang, Z Jiang   +172 more
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A metabolite-derived protein modification integrates glycolysis with KEAP1-NRF2 signalling. [PDF]

, 2018
Mechanisms that integrate the metabolic state of a cell with regulatory pathways are necessary to maintain cellular homeostasis. Endogenous, intrinsically reactive metabolites can form functional, covalent modifications on proteins without the aid of ...
A Cleasby, A Dhar, A Kobayashi, A Moraru, A Shevchenko, A Uruno, AC Ruifrok, Arnab K. Chatterjee, BR Sabari, BT Weinert, CL Saw, Claudio Zambaldo, D Martinez Molina, DD Zhang, Emily N. Chin, FW Chaplen, Gihoon Lee, GP Sykiotis, GR Wagner, H Lin, Hwayoung Yun, Insha Ahmad, Jae Won Chang, John S. Coukos, JW Chang, Luke L. Lairson, M Ravichandran, MC Jaramillo, Michael J. Bollong, N Rabbani, N Rabbani, N Wakabayashi, Peter G. Schultz, Raymond E. Moellering, RE Moellering, RH Scannevin, S Nishimoto, S Tao, SC Lo, T Bücher, T Ogura, TB El-Abaseri, TO Khor, TW Lo, W Hur, W Hur, Y Mitsuishi, Z Zhang   +47 more
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4-(3-Nitrophenyl)thiazol-2-ylhydrazone derivatives as antioxidants and selective hMAO-B inhibitors: synthesis, biological activity and computational analysis [PDF]

, 2019
A new series of 4-(3-nitrophenyl)thiazol-2-ylhydrazone derivatives were designed, synthesised, and evaluated to assess their inhibitory effect on the human monoamine oxidase (hMAO) A and B isoforms. Different (un)substituted (hetero)aromatic substituents
Alcaro, Stefano, Bagetta, Donatella, Carradori, Simone, Chimenti, Paola, D’Ascenzio, Melissa, Guglielmi, Paolo, Ortuso, Francesco, Petzer, Anél, Petzer, Jacobus P., Secci, Daniela, Zengin, Gokhan   +10 more
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Emerging glycolysis targeting and drug discovery from chinese medicine in cancer therapy [PDF]

, 2012
Molecular-targeted therapy has been developed for cancer chemoprevention and treatment. Cancer cells have different metabolic properties from normal cells.
Chen, J, Shen, J, Wang, N, Wang, Z
core   +1 more source

Countercurrent chromatography in analytical chemistry (IUPAC technical report) [PDF]

, 2009
© 2009 IUPACCountercurrent chromatography (CCC) is a generic term covering all forms of liquid-liquid chromatography that use a support-free liquid stationary phase held in place by a simple centrifugal or complex centrifugal force field. Biphasic liquid
Abbey, Abe, Abe, Abe, Akiba, Akiba, Akiba, Alain Berthod, Bauer, Bauer, Berthod, Berthod, Berthod, Berthod, Berthod, Berthod, Billardello, Boris Spivakov, Chen, Chen, Chen, Chen, Chmutova, Chmutova, Chmutova, Conway, Conway, Conway, Countercurrent Chromatography, Dekker, Fedotov, Fitz, Friesen, Fujita, Garcia Dominguez, Hashimoto, Hashimoto, Ian A. Sutherland, Ikai, Ito, Ito, Ito, Ito, Ito, Jin, Jin, Jin, Kawamura, Kawamura, Kidwell, Kitazume, Kitazume, Kitazume, Kitazume, Kitazume, Kong, Lee, Lee, Lee, Lee, Liu, Ma, Ma, Mandava, Mandava, Marston, Marston, Marston, Maryutina, Maryutina, Maryutina, Maryutina, Maryutina, Matsuda, Menet, Muralidharan, Nakamura, Nakamura, Oleg Shpigun, Pauli, Pukhovskaya, Ruiz, Ruiz, Ruth, Schaufelberger, Schaufelberger, Schreiber, Shang, Spivakov, Spivakov, Spivakov, Stark, Sutherland, Tanaka, Tatyana Maryutina, Thurman, Tian, Usuda, Usuda, Wang, Wang, Watkins, Winterhalter, Wood, Wu, Yanagida, Yang, Yang, Yang, Yoshida, Yu, Zhang, Zhang   +112 more
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Prediksi Potensi Koleksi Kebun Raya Purwodadi Sebagai Anti-Coronavirus: Sebuah Kajian Literatur [PDF]

, 2022
AbstrakSARS-CoV-2 dikenal sebagai agen penyebab COVID-19. Penyakit ini pertama kali muncul di Cina yang dalam beberapa bulan telah menyebar secara masif ke 198 negara lain termasuk Indonesia, dan menyebabkan pandemik global.
Angio, Melisnawati H., Firdiana, Elok Rifqi, Ningrum, Linda Wige, Renjana, Elga, Rizal, Syaiful   +4 more
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A comparative study of Salvia miltiorrhiza Radix & Rhizoma raw material and granule products using chromatographic analysis and antioxidant activity [PDF]

, 2022
Objective: Granules of herbal extracts are a popular medicinal preparation consumed in traditional Chinese medicine clinical practice. However, their quality and efficacy evaluation are lacking.
Chan, Kelvin (R15157), Mendoza, Raynold, Razmovski-Naumovski , Valentina (R16317), Truong, John, Zhou, Xian (R17201)   +4 more
core   +1 more source

Preclinical and clinical examinations of Salvia miltiorrhiza and its tanshinones in ischemic conditions [PDF]

, 2006
Salvia miltiorrhiza (Labiatae, Laminaceae), danshen, is an annual sage mainly found in China and neighboring countries. The crude drug (dried root) and its preparations are currently used in China to treat patients suffering from heart attack, angina ...
Lien Eric, Yang Jun, Wang Rubin, Adams James   +3 more
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