Results 61 to 70 of about 14,833,612 (178)

Development of Potential Multi-Target Inhibitors for Human Cholinesterases and Beta-Secretase 1: A Computational Approach [PDF]

open access: yes, 2023
Alzheimer’s disease causes chronic neurodegeneration and is the leading cause of dementia in the world. The causes of this disease are not fully understood but seem to involve two essential cerebral pathways: cholinergic and amyloid.
Barbosa, Deyse B.   +9 more
core   +1 more source

Advanced Pharmaceutical Nanotechnologies Applied for Chinese Herbal Medicines

open access: yesAdvanced Science, Volume 12, Issue 31, August 21, 2025.
This review offers a comprehensive overview of pharmaceutical nanotechnology strategies to address limitations associated with the complex material basis and relative mild therapeutic efficacy of Chinese herbal medicines, and summarizes the advantages of these strategies.
Jiameng Li   +11 more
wiley   +1 more source

A review study on medicinal plants affecting amnesia through cholinergic system [PDF]

open access: yes, 2012
Neurotransmitter modification is an important method for the treatment of memory loss or amnesia. Cholinomimetic drugs, particularly, acetylcholine esterase inhibitors are the mainstream in pharmacotherapy of amnesia. Donepezil, tacrine, galantamine, and
Baradaran, Azar.   +3 more
core  

In Situ Assembly of Fluorogenic RNA for Screening Natural Anti‐Liver Fibrosis Products via Dynamic Visualization of COL1A1 mRNA

open access: yesAdvanced Science, Volume 12, Issue 30, August 14, 2025.
This study introduces an in situ assembly of fluorogenic RNA approach for screening natural anti‐liver fibrosis compounds and dynamic visualization of endogenous COL1A1 mRNA in live cells. It offers a simple, cost‐effective approach of visualizing RNA dynamics and conducting drug screening in live cells, presenting a significant potential for the ...
Rui Bai   +6 more
wiley   +1 more source

Salvia miltiorrhiza extract dihydrotanshinone induces apoptosis and inhibits proliferation of glioma cells [PDF]

open access: yes, 2017
Dihydrotanshinone, a functional food in China, is an effective anti-cardiovascular disease substance isolated from Salvia miltiorrhiza (S. miltiorrhiza). Glioma is considered to be fatal due to its poor prognosis and few effective therapeutic options. In
Bin Huang, Changqing Gao, Yong Cao
core   +2 more sources

RNA Epigenetics in Cancer: Current Knowledge and Therapeutic Implications

open access: yesMedComm, Volume 6, Issue 8, August 2025.
RNA epigenetics regulates cancer through RNA modifications, splicing, transport, and translation. Key components include m⁶A writers, splicing factors, RBPs, and nuclear export machinery. Aberrant RNA metabolism drives tumor progression and immune evasion.
Shanhe Huang   +4 more
wiley   +1 more source

A network pharmacology-based study on the anti-hepatoma effect of Radix Salviae Miltiorrhizae [PDF]

open access: yes, 2020
This work is licensed under a Creative Commons Attribution 4.0 International License.Background Radix Salviae Miltiorrhizae (RSM), a well-known traditional Chinese medicine, has been shown to inhibit tumorigenesis in various human cancers.
Almutairi, Mohammed M.   +11 more
core   +2 more sources

Dihydrotanshinone I inhibits gallbladder cancer growth by targeting the Keap1-Nrf2 signaling pathway and Nrf2 phosphorylation.

open access: yesPhytomedicine
BACKGROUND Gallbladder cancer (GBC) poses a significant risk to human health. Its development is influenced by numerous factors, particularly the homeostasis of reactive oxygen species (ROS) within cells.
Zhuang Li   +10 more
semanticscholar   +1 more source

Development and application of base editing systems in Salvia miltiorrhiza for precise metabolic engineering

open access: yes
Plant Biotechnology Journal, Volume 23, Issue 12, Page 5619-5621, December 2025.
Qi Yao   +10 more
wiley   +1 more source

Recent Advances in Cancer Cell Membrane‐Based Nanoparticles and Cancer Cell‐Derived Small Extracellular Vesicles as Drug Delivery Platforms

open access: yesAdvanced NanoBiomed Research, Volume 5, Issue 6, June 2025.
Cancer cell membrane‐based nanoparticles (CCM‐NPs) and cancer cell‐derived small extracellular vesicles (CsEVs) are emerging as promising drug delivery systems for targeted cancer treatment. Advances in nanotechnology have paved the way for innovative drug delivery systems that enhance the effectiveness of cancer treatment.
Wei Zhang   +4 more
wiley   +1 more source

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