Results 71 to 80 of about 14,833,612 (178)

Role of P2X7R in Retinal Diseases: A Review

Immunity, Inflammation and Disease, Volume 13, Issue 5, May 2025.
ABSTRACT Background P2X purinoceptor 7 receptor (P2X7R) is an ATP‐gated ion channel that, upon activation by ATP, triggers the release of inflammatory mediators and induces apoptosis in cells. This channel plays a crucial role in the onset and progression of various diseases.
Chunli Li, Binsheng Wang
wiley   +1 more source

Potential Chemoprotective Effects of Active Ingredients in Salvia miltiorrhiza on Doxorubicin-Induced Cardiotoxicity: A Systematic Review of In Vitro and In Vivo Studies [PDF]

, 2023
BACKGROUND: Recently, attention has been paid to the protective properties of active ingredients in METHODS: According to the PRISMA guideline, the current systematic review was conducted in the Web of Science, PubMed, Embase, and the Cochrane Library to
Chu, Xuelei, Jiang, Xiaochen, Li, Jiaxian, Li, Yi, Liu, Fudong, Pang, Bo, Shen, Qian, Wang, Qingqing, Zhang, Chuanlong, Zhang, Xiyuan   +9 more
core   +1 more source

Synthesis and Preliminary Evaluation of Tanshinone Mimic Conjugates for Mechanism of Action Studies

ChemBioChem, Volume 26, Issue 6, March 15, 2025.
A small array of Tanshinone Mimics (TM) probes with a detection‐promoting moiety (either a photoaffinity probe ‐ PAP or biotin) has been synthesized for mechanism of action (MoA) studies on Human antigen R (HuR). Biological and biochemical assays were used to characterize the novel TM conjugates.
Giulia Assoni, Ágata Sofia Assunção Carreira, Matteo Tomiello, Pierfausto Seneci, Alessandro Provenzani, Daniela Arosio   +5 more
wiley   +1 more source

Herbal product's quality control using ¹H-NMR metabolomics approach – An example from Danshen (Salvia miltiorrhiza Bunge.) [PDF]

, 2020
Radix Salviae miltiorrhizae is the only source of Danshen in pharmacopoeias. For thousands of years, it has been used in China for vascular and pain-related diseases.
Kum, Ka Yui
core  

Dihydrotanshinone I inhibits angiogenesis both in vitro and in vivo.

Acta biochimica et biophysica Sinica, 2008
Dihydrotanshinone I (DI), a naturally occurring compound extracted from Salvia miltiorrhiza Bunge, has been reported to have cytotoxicity to a variety of tumor cells. In this study, we investigated its anti-angiogenic capacity in human umbilical vein endothelial cells.
Weipeng, Bian, Fei, Chen, Ling, Bai, Ping, Zhang, Wenxin, Qin   +4 more
openaire   +1 more source

Anticholinesterase and carbonic anhydrase inhibitory activities of natural carnosic acid derivatives: A comprehensive in vitro and in silico study

Archiv der Pharmazie, Volume 358, Issue 3, March 2025.
Carnosic acid derivatives were evaluated for their inhibitory activities against acetyl‐ and butyrylcholinesterases (AChE, BChE) and carbonic anhydrases (CAs). Rosmanol exhibited exceptional potency, surpassing tacrine and acetazolamide. Molecular docking, MM‐GBSA, and MD simulations confirmed strong binding and stability.
Zeynep Köksal, Halil Şenol
wiley   +1 more source

Retraction: Dihydrotanshinone I inhibits hepatocellular carcinoma cells proliferation through DNA damage and EGFR pathway

PeerJ
europepmc   +2 more sources

Controlled Drug Release Systems for Cerebrovascular Diseases

Advanced Therapeutics, Volume 8, Issue 1, January 2025.
Today, controlled drug delivery systems for cerebrovascular and neurological diseases have been greatly optimized. This review highlights the importance of precise drug targeting and the underlying mechanisms of these delivery systems, as well as their potential to improve therapeutic outcomes and minimize adverse effects.
Celia Martín‐Morales, Sofia Caspani, Manuel Desco, Célia Tavares de Sousa, María Victoria Gómez‐Gaviro   +4 more
wiley   +1 more source

PD-L1 antibody conjugated dihydrotanshinone I-loaded polymeric nanoparticle for targeted cancer immunotherapy combining PD-L1 blockade with immunogenic cell death.

International journal of pharmaceutics
PURPOSE Combination immune checkpoint inhibitors (ICI) with chemotherapeutic agents has proven to be highly promising in cancer therapy. However, low response rate, immune-related adverse events, and lack of effectively targeted co-delivery strategy are ...
Xue Wang, Ziqi Jing, Xiaobin Huang, Xiaoya Liu, Yujie Zhang, Zhijun Wang, Pengkai Ma   +6 more
semanticscholar   +1 more source

Targeting Fibrosis: From Molecular Mechanisms to Advanced Therapies

Advanced Science, Volume 12, Issue 3, January 20, 2025.
This review comprehensively summarizes the advances in research for fibrosis. It emphasizes organ‐specific profibrotic cell types and molecular mechanisms of fibrosis, especially in the kidney, liver, lung, and heart. The authors highlight the advanced antifibrotic small molecule drugs and cellular therapies for fibrosis.
Xingpeng Di, Ya Li, Jingwen Wei, Tianyue Li, Banghua Liao   +4 more
wiley   +1 more source