Challenges in Therapeutically Targeting the RNA‐Recognition Motif
WIREs RNA, Volume 15, Issue 6, November/December 2024.Targeting of RNA recognition motifs can modulate mRNA processing and provide new therapeutic strategies. Challenges in selectivity and potency suggest that alternative targeting strategies are required for efficient inhibition. ABSTRACT The RNA recognition motif (RRM) is the most common RNA binding domain found in the human proteome.
Stefan Schmeing, Peter 't Hart
wiley +1 more source
Exploration of ligand binding modes towards the identification of compounds targeting HuR : a combined STD-NMR and Molecular Modelling approach [PDF]
, 2018 Post-transcriptional processes have been recognised as pivotal in the control of gene expression, and impairments in RNA processing are reported in several pathologies (i.e., cancer and neurodegeneration).
Alcaro, Stefano +12 more
core +1 more source
A Review: Surface Engineering of Lipid‐Based Drug Delivery Systems
Small, Volume 20, Issue 43, October 24, 2024.Lipid‐based nanoparticles are effective drug‐delivery systems primarily consisting of liposomes and membrane‐based nanoparticles. The potential of liposomes can be improved through surface modification. Liposomes can be transformed into biomimetic nanoparticles by coating them with various cell membranes originating from immune cells, circulatory cells,
Dhaval Patel +3 more
wiley +1 more source
Roles of Reactive Oxygen Species in Anticancer Therapy with Salvia miltiorrhiza Bunge [PDF]
, 2016 Cancer is a leading cause of death worldwide. We aim to provide a systematic review about the roles of reactive oxygen species (ROS) in anticancer therapy with Salvia miltiorrhiza Bunge (Danshen).
Tai-Long Pan +2 more
core +2 more sources
UHPLC-HRMSn Analysis Reveals the Dynamic Metabonomic Responses of Salvia miltiorrhiza Hairy Roots to Polysaccharide Fraction from Trichoderma atroviride [PDF]
We have previously reported that Trichoderma atroviride, an endophytic fungus isolated from S. miltiorrhiza, promotes S. miltiorrhiza hairy root growth and significantly stimulates the biosynthesis of tanshinones specifically the polysaccharide fraction (
Dong, X +8 more
core +1 more source
Selective in vitro and in silico butyrylcholinesterase inhibitory activity of diterpenes and rosmarinic acid isolated from Perovskia atriplicifolia Benth. and Salvia glutinosa L. [PDF]
, 2017 Cholinesterase inhibition is one of the most treatment strategies against Alzheimer's disease (AD) where metal accumulation is also strongly associated with pathology of the disease.
Cerón Carrasco, José P. +10 more
core +2 more sources
Novel usage of medicinal herbs for treating Alzheimer disease. [PDF]
, 2004 by Tsz-Wan Ho.Thesis submitted in: July 2003.Thesis (M.Phil.)--Chinese University of Hong Kong, 2004.Includes bibliographical references (leaves 107-122).Abstracts in English and Chinese.Acknowledgements --- p.iAbstract --- p.ii摘要 --- p.ivContent ---
core
The inhibition of SARS-CoV-2 Papain-like protease by tanshinones [PDF]
The emergence of SARS-CoV-2, the virus responsible for the COVID-19 pandemic, has highlighted the critical need for effective antiviral treatments. Three significant coronaviruses—SARS-CoV-1, MERS-CoV, and SARS-CoV-2—have posed serious global health ...
Beringer, Alex
core +1 more source
Comparison of Extraction Efficiency of Tanshinones from S. miltiorrhiza by Solvent and Supercritical Carbon Dioxide [PDF]
, 2016 Salvia miltiorrhiza (S. miltiorrhiza), also named as Danshen, is a traditional Chinese herbal medicine reported to possess anti-cancer and anti-inflammation activities, which can be attributed to presence of the major functional components tanshinones ...
Chen, Huei, Lee, Wei- Der
core +1 more source
Opposite effects of single-dose and multidose administration of the ethanol extract of danshen on [PDF]
, 2013 The aim of this study was to investigate the effect of single-and multidose administration of the ethanol extract of danshen on in vivo CYP3A activity in healthy volunteers.
Chenglu Gao +12 more
core