Results 121 to 130 of about 49,544 (290)

Autonomous Nanomedicine: Closing the Biological Validation Gap

Exploration, EarlyView.
Delivery of nanoparticles to tumors has not improved in over fifteen years, and biological testing remains slow and separate from formulation design. This review proposes adding a Biology step to the design cycle, using organ chips and patient‐derived organoids, and assesses the readiness of each required technology.
Yan Jun Lin, Izabella Komperda
wiley   +1 more source

MLH1 p.His112Arg Variant Is Associated With Increased Cancer Susceptibility

International Journal of Cancer, EarlyView.
ABSTRACT Lynch syndrome, a prevalent hereditary cancer predisposition, is frequently caused by pathogenic variants in the MutL homolog 1 (MLH1) mismatch repair gene. However, a significant proportion of MLH1 missense variants remain classified as variants of uncertain significance (VUS), creating clinical ambiguity.
Amal Elfatih, Issam Tout, Najwa Ahmad Doha, Tala Abu Arja, Idris Mohammed, Doua Abdelrhaman, Waseem Hasan, Chadi Saad, Hamdi Mbarek, Borbala Mifsud, Sahar Isa Da'as   +10 more
wiley   +1 more source

Simultaneous CARS and TPF microscopy captures LD changes induced by single amino acid mutations in GFP-tagged DII-core¹⁶¹ expressing Huh-7 cells.

, 2013
All images were collected approximately 20 hours after Huh-7 cells were transfected with (A) DII-coreG161F, (B) DII-coreG161L, (C) DII-coreG161S, and (D) DII-coreG161A.
Allison R. Sherratt (478883), John Paul Pezacki (425841), John McLauchlan (425839), Rodney K. Lyn (425833), Graham Hope (478882)   +4 more
core   +1 more source

Engineered 3D cultured human nasal mucosa mesenchymal stem cell derived sEVs for targeted brain‐derived neurotrophic factor delivery to enhance neurogenesis and attenuate brain damage

Interdisciplinary Medicine, EarlyView.
This study successfully developed and evaluated BDNF@RVG‐sEVs, a novel brain‐targeted nanomedicine based on hnmMSC‐derived sEVs, designed to overcome the BBB and enhance neurorestoration. By integrating RVG for enhanced brain targeting and encapsulating BDNF for potent neurorepair, our system address the key limitations of the conventional sEVs and ...
Xueting Wang, Junge Chen, Jiao Xia, Weitong Yang, Teng Ma, Tianzi Shan, Weifeng He, Gaoman Zhang, Zhuoran Xia, Weiwei Wang, Zhusheng Liu, Zhiqiang Yi, Piye Niu, Tian Chen   +13 more
wiley   +1 more source

Pirates Run Sixth At DII Georgia Collegiate Championship [PDF]

, 2015
Pirates Run Sixth At DII Georgia Collegiate Championship. The Armstrong State University men\u27s cross country team finished sixth out of 11 schools at the DII Georgia Collegiate XC Championship, hosted by Georgia College on Saturday morning in ...
Armstrong State University
core  

Enhanced c-Fos expression in DiI-labeled DRG neurons following HT7-MAI stimulation.

, 2013
A-C: Immunofluorescent images of the expression of c-Fos (B) in DiI-labeled DRG neurons (A) from control group (no stimulation at HT7). D-F: The expression of c-Fos (E) in DiI-labeled DRG neurons (D) following MAI stimulation at HT7. The numbers of c-Fos
Kwang Joong Kim (486419), Yeon-Hee Ryu (486421), Bong Hyo Lee (486417), Jong Han Bae (486418), Seol Ah Kim (486416), Scott C. Steffensen (486420), Joong Woo Leem (149843), Hee Young Kim (380436), Chae Ha Yang (486422)   +8 more
core   +1 more source

COX5A promotes cell progression and cisplatin‐resistance by alleviating mitochondrial dysfunction in head and neck squamous cell carcinoma

Precision Medical Sciences, EarlyView.
COX5A promotes cell progression and cisplatin‐resistance and alleviates mitochondrial dysfunction. ISG15 shows a reversing role with COX5A. Targeting the COX5A‐mediated mitochondrial metabolic pathway may offer a novel therapeutic approach to enhance cisplatin sensitivity in HNSCC.
Nannan Guo, Zhangyu Yao, Bo Gui, Qingya Sun, Yihan Tang, Tingting Hu, Yanbin Zhao, Fangzhou Liu   +7 more
wiley   +1 more source

DIY whitening [PDF]

British Dental Journal, 2017
openaire   +2 more sources

RGCs and ON labeled with DiI in vivo.

, 2013
(A) Schematic diagram of DiI labeling: after partial incision in the dorsal ON 1.0 mm from the optic disc, several crystals of DiI were precisely placed into the incision.
Kin Chiu (323246), Qiuju Yuan (104285), Kwok-Fai So (143423), Yuxiang Liang (435295), Raymond Chuen-Chung Chang (302180), Hongying Li (36664), Bin Lin (302181)   +6 more
core   +1 more source

Betulinic Acid Counteracts Statin‐Induced PCSK9 Upregulation Through FXR/SHP‐Associated Signaling

Phytotherapy Research, EarlyView.
Betulinic acid attenuates atorvastatin‐induced increases in PCSK9 expression and secretion while maintaining or increasing LDLR expression in hepatocyte‐derived cells. Mechanistic studies support the involvement of FXR/SHP signaling and show increased SHP–SREBP2 association.
Chan‐Woong Park, Mingoo Bae, Pureum Kang, Na Young Lee, Ja Hyun Koo, Young Hee Choi, Young‐Won Chin   +6 more
wiley   +1 more source