Results 271 to 280 of about 261,108 (323)

Safety, tolerability, pharmacokinetics and pharmacodynamics of HSK31858, a novel oral dipeptidyl peptidase‐1 inhibitor, in healthy volunteers: An integrated phase 1, randomized, double‐blind, placebo‐controlled, single‐ and multiple‐ascending dose study

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Dipeptidyl peptidase‐1 (DPP‐1) inhibitors have been studied for the treatment of neutrophil‐mediated inflammatory diseases including bronchiectasis, bronchial asthma and cystic fibrosis. This study evaluated the pharmacokinetics, pharmacodynamics, safety and tolerability of DPP‐1 inhibitor HSK31858 in healthy Chinese volunteers.
Yuhao Wang, Chao Yu, Mengyue Hu, Lu Wang, Meixia Chen, Hanmo Liu, Nan Wu, Jie Hou   +7 more
wiley   +1 more source

Early cholangioscopy-guided lithotripsy for clearance of biliary stones associated with narrow lower bile duct. [PDF]

Endosc Int Open
Gupta P, Singla V, Singh P, Madan K, Kaalia S, Shawl MR, Goel A, Garg P, Bhargava R.   +8 more
europepmc   +1 more source

The tacrolimus concentration‐to‐dose ratio is associated with kidney function in heart transplant recipients

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Heart transplantation (HT) is frequently complicated by chronic kidney disease, of which tacrolimus‐related nephrotoxicity is an important cause. In kidney and liver transplant recipients, fast tacrolimus metabolism (defined as a low concentration‐to‐dose [C0/D] ratio), negatively affects kidney function.
Maaike R. Schagen, Teun B. Petersen, Boris C. A. Seijkens, Jasper J. Brugts, Kadir Caliskan, Alina A. Constantinescu, Brenda C. M. de Winter, Isabella Kardys, Dennis A. Hesselink, Olivier Manintveld   +9 more
wiley   +1 more source

A case report of atypical autosomal dominant polycystic kidney disease presenting as glomerulocystic kidney superimposed with thin basement membrane nephropathy. [PDF]

BMC Nephrol
Wang W, Chen L, Ding F, Li X.
europepmc   +1 more source

Genetic causal association between heart failure, frailty and poisoning by narcotics and psychodysleptics: A two‐sample Mendelian randomization

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims Observational studies have suggested associations between heart failure (HF), frailty and poisoning by narcotics and psychodysleptics (PNP). However, establishing causal relationships has been challenging. This study used a two‐sample Mendelian randomization (MR) approach to investigate the genetically proxied causality between HF ...
Bing Wang, Hong Yu, Meng Cai, Xianqiao Xie   +3 more
wiley   +1 more source

Endourological treatment of ureteral strictures with the use of self-expanding stents: is it possible to completely cure the stricture endoscopically? A report on the experience with implantation of 35 stents with a two-year follow-up period; a retrospective study. [PDF]

World J Urol
Kowalski F, Kuffel B, Późniak M, Lipowski P, Czarnogorski M, Wilamowski J, Ostrowski A, Adamowicz J, Drewa T.   +8 more
europepmc   +1 more source

Human Cervix Chip: A Preclinical Model for Studying the Role of the Cervical Mucosa and Microbiome in Female Reproductive Health

BioEssays, EarlyView.
The microfluidic Cervix Chip is an in vitro model of the human cervix lined by cervical epithelium interfaced with stromal cells cultured under dynamic flow that represents a new preclinical platform for studying mucosal immunity, host‐microbiome interactions, infections, fertility, and pregnancy health.
Zohreh Izadifar, Anna Stejskalova, Aakanksha Gulati, Ola Gutzeit, Donald E. Ingber   +4 more
wiley   +1 more source

Pancreas Divisum With Santorinicele: A Rare Cause of Recurrent Acute Pancreatitis. [PDF]

Cureus
Alkhamis FA, Al Ali MT, Aslan A.
europepmc   +1 more source

Exploring the Interrelationship Between Energy, Geopolitical Risk, and Bitcoin Based Green Business Strategies

Business Strategy and the Environment, EarlyView.
ABSTRACT This study examined how Bitcoin, energy prices, and geopolitical risk interact by examining the first four moments (mean, variance, skewness, and kurtosis) of their return distributions by using wavelet analysis. The findings reveal that the co‐movement patterns of energy index, geopolitical risk index, and Bitcoin prices are time and ...
Pooja Kumari, Amit Shankar, Rsha Alghafes, Laura Broccardo, Steven T. Walsh   +4 more
wiley   +1 more source

Late post-operative cardiogenic shock from left main coronary compression in tetralogy of Fallot with absent pulmonary valve: a case report. [PDF]

Eur Heart J Case Rep
Kothari SS, Sharma V, Patel K, Thakut G, Parikh R.   +4 more
europepmc   +1 more source