Results 1 to 10 of about 580,532 (393)

A predictive model for canine dilated cardiomyopathy—a meta-analysis of Doberman Pinscher data [PDF]

PeerJ, 2015
Dilated cardiomyopathy is a prevalent and often fatal disease in humans and dogs. Indeed dilated cardiomyopathy is the third most common form of cardiac disease in humans, reported to affect approximately 36 individuals per 100,000 individuals.
Siobhan Simpson, Jennifer Edwards, Richard D. Emes, Malcolm A. Cobb, Nigel P. Mongan, Catrin S. Rutland   +5 more
doaj   +9 more sources

Natural genetic variation of the cardiac transcriptome in non-diseased donors and patients with dilated cardiomyopathy [PDF]

Genome Biology, 2017
Background Genetic variation is an important determinant of RNA transcription and splicing, which in turn contributes to variation in human traits, including cardiovascular diseases. Results Here we report the first in-depth survey of heart transcriptome
Matthias Heinig, Michiel E. Adriaens, Sebastian Schafer, Hanneke W. M. van Deutekom, Elisabeth M. Lodder, James S. Ware, Valentin Schneider, Leanne E. Felkin, Esther E. Creemers, Benjamin Meder, Hugo A. Katus, Frank Rühle, Monika Stoll, François Cambien, Eric Villard, Philippe Charron, Andras Varro, Nanette H. Bishopric, Alfred L. George, Cristobal dos Remedios, Aida Moreno-Moral, Francesco Pesce, Anja Bauerfeind, Franz Rüschendorf, Carola Rintisch, Enrico Petretto, Paul J. Barton, Stuart A. Cook, Yigal M. Pinto, Connie R. Bezzina, Norbert Hubner   +30 more
doaj   +3 more sources

Immune-inflammatory concept of the pathogenesis of chronic heart failure in dogs with dilated cardiomyopathy [PDF]

Veterinary World, 2019
Background: Dilated cardiomyopathy is common in dogs. This form of cardiomyopathy is the main cause of death due to heart disease in dogs. Death can occur suddenly in clinically normal animals as a result of the progression of congestive heart failure ...
Yu Vatnikov, A. Rudenko, P. Rudenko, Ev Kulikov, A. Karamyan, V. Lutsay, I. Medvedev, V. Byakhova, E. Krotova, M. Molvhanova   +9 more
doaj   +2 more sources

Similar burden of rare genetic variants in ischemic and non-ischemic dilated cardiomyopathy [PDF]

Frontiers in Cardiovascular Medicine
BackgroundThe aim of the study was to determine the prevalence of rare disease-causing variants in cardiomyopathy-associated genes in a cohort of patients with ischemic and non-ischemic dilated cardiomyopathy undergoing heart transplant.MethodsWe ...
Louie Cao, Joshua Rushakoff, Ian Williamson, Anja Karlstaedt, Michelle Kittleson, Lawrence Czer, Evan P. Kransdorf   +6 more
doaj   +2 more sources

Demographic and regional mortality trends in dilated cardiomyopathy in the United States; 1999–2020 [PDF]

SAGE Open Medicine
Background: Dilated cardiomyopathy significantly impacts mortality and hospitalizations in the U.S., yet trends in dilated cardiomyopathy-related mortality are underreported.
Syed Sarmad Javaid, Syed Usama Ashraf, Anoud Khan, Muntaha Irfan, Muhammad Usman Alamgir, Syed Daniyal Ahmed Jilanee, Hamiz Faisal, Muhammad Salman Peryani, Noor Ul Ain, Ismail Khan   +9 more
doaj   +2 more sources

OBSCN Mutations Associated with Dilated Cardiomyopathy and Haploinsufficiency [PDF]

, 2015
Studies of the functional consequences of DCM-causing mutations have been limited to a few cases where patients with known mutations had heart transplants.
Choi, O, Copeland, O, dos Remedios, C, Ehler, E, Knoll, R, Marston, SB, Messer, AE, Montgiraud, C, Munster, AB   +8 more
core   +27 more sources

Layer-Specific Strain Analysis in Patients with Dilated Cardiomyopathy [PDF]

Biomedicines
Background/Objectives: This study aimed to evaluate layer-specific strain according to etiology and assess whether subtle changes in longitudinal and circumferential layer strain are involved in predicting cardiac mortality during a two-year follow-up in
Despina-Manuela Toader, Alina Paraschiv, Georgică Târtea, Gabriela Tiucu, Mihai Chițu, Raluca Stănișor, Oana Mirea   +6 more
doaj   +2 more sources

Precise genomic editing of pathogenic mutations in RBM20 rescues dilated cardiomyopathy

Science Translational Medicine, 2022
Mutations in RNA binding motif protein 20 (RBM20) are a common cause of familial dilated cardiomyopathy (DCM). Many RBM20 mutations cluster within an arginine/serine-rich (RS-rich) domain, which mediates nuclear localization. These mutations induce RBM20
Takahiko Nishiyama, Yu Zhang, Miao Cui, Hui Li, E. Sánchez-Ortiz, John R. McAnally, Wei Tan, Jiwoong Kim, Kenian Chen, Lin Xu, R. Bassel-Duby, E. Olson   +11 more
semanticscholar   +1 more source

Evidence-Based Assessment of Genes in Dilated Cardiomyopathy

Circulation, 2021
Supplemental Digital Content is available in the text. Background: Each of the cardiomyopathies, classically categorized as hypertrophic cardiomyopathy, dilated cardiomyopathy (DCM), and arrhythmogenic right ventricular cardiomyopathy, has a signature ...
Elizabeth Jordan, Laiken Peterson, Tomohiko Ai, B. Asatryan, L. Bronicki, Emily E. Brown, R. Celeghin, Matthew Edwards, Judy Fan, J. Ingles, C. James, O. Jarinova, Renee Johnson, Daniel P. Judge, N. Lahrouchi, R. L. Lekanne Deprez, R. Lumbers, F. Mazzarotto, A. Medeiros Domingo, Rebecca L. Miller, A. Morales, B. Murray, Stacey Peters, K. Pilichou, Alexandros Protonotarios, C. Semsarian, Palak Shah, P. Syrris, C. Thaxton, J. V. van Tintelen, R. Walsh, Jessica Wang, James S. Ware, R. E. Hershberger   +33 more
semanticscholar   +1 more source

Truncated titin proteins in dilated cardiomyopathy

Science Translational Medicine, 2021
Description Truncating mutations in TTN result in both truncated titin proteins and reduced full-length titin in patient hearts. Tracking titin in dilated cardiomyopathy Truncating variants in TTN, the gene encoding the titin protein, underlie 15 to 25 ...
Q. McAfee, C. Y. Chen, Yifan Yang, M. Caporizzo, M. Morley, A. Babu, Sunhye Jeong, Jeffrey Brandimarto, K. Bedi, Emily Flam, Joseph Cesare, T. Cappola, K. Margulies, B. Prosser, Z. Arany   +14 more
semanticscholar   +1 more source