Results 81 to 90 of about 580,532 (393)

Dilated cardiomyopathy in children

Journal of the American College of Cardiology, 1988
Dilated cardiomyopathy is a rare but serious disease in children. Clinical manifestations are primarily due to impaired systolic function of the left ventricle. Diagnostic evaluation is important to exclude masquerading cardiac abnormalities and to assess the degree of myocardial dysfunction.
openaire   +3 more sources

Hereditary dilated cardiomyopathy

Clinical Cardiology, 1995
AbstractDilated cardiomyopathy (DCM) is a common and important cause of morbidity and mortality. Many factors can contribute to the development of this disorder, although most commonly the etiology is unexplained. However, recent studies in individuals with idiopathic DCM now reveal a heritable cause in 20–30% of individuals.
John Ross, Thomas R. Mcminn
openaire   +3 more sources

LncRNA Foxo6os as a Novel “ Scaffold” Mediates MYBPC3 in Combating Pathological Cardiac Hypertrophy and Heart Failure

Advanced Science, EarlyView.
Schematic overview showing that forkhead box O6, opposite strand (Foxo6os) acts as a “scaffold”, directly binding myosin‐binding protein‐C (MYBPC3) and recruiting protein kinase C (PKC‐α) to mediate site‐specific phosphorylation of MYBPC3. This post‐translational modification supports cardiac contraction by regulating L‐type Ca2+ channels, especially ...
Jie Sheng, Qin Lin, Yizhuo Sun, Yilei Meng, Sangyu Hu, Huaming Cao, Fang Lin, Yuping Zhu, Luying Peng, Li Li   +9 more
wiley   +1 more source

RBM20 Mutations Induce an Arrhythmogenic Dilated Cardiomyopathy Related to Disturbed Calcium Handling

Circulation, 2018
Background: Mutations in RBM20 (RNA-binding motif protein 20) cause a clinically aggressive form of dilated cardiomyopathy, with an increased risk of malignant ventricular arrhythmias.
M. V. D. van den Hoogenhof, A. Beqqali, A. Amin, I. van der Made, Simona Aufiero, Mohsin A. F. Khan, C. Schumacher, Joeri A. Jansweijer, K. V. van Spaendonck‐Zwarts, C. Remme, J. Backs, A. Verkerk, A. Baartscheer, Y. Pinto, E. Creemers   +14 more
semanticscholar   +1 more source

Severe reversible dilated cardiomyopathy associated with a large left ventricular thrombus in a young child with middle aortic syndrome [PDF]

, 2014
this article reports a case of a seven-year girl who presented with severe dilated cardiomyopathy (DCM) associated with a large thrombus in the left ventricle (LV). She had a long segment stenosis of the lower thoracic descending aorta, possibly due to
Overholt, Ed, Ponniah, Umakumaran
core   +1 more source

Atrial Fibroblasts‐Derived Extracellular Vesicles Exacerbate Atrial Arrhythmogenesis

Advanced Science, EarlyView.
Exosome miR‐224‐5p derived from angiotensin II‐treated atrial fibroblasts creates a substrate for AF by promoting atrial electrical remodeling. Increased exosome miR‐224‐5p enhances AF susceptibility by inhibiting CACNA1c expression and decreasing ICa current of atrial cardiomyocytes.
Yue Yuan, Xinbo Zhao, Xuejie Han, Yukai Cao, Xuexin Jin, Ling Shi, Xin Bi, Desheng Li, Yun Zhang, Wenbo Ma, Jiahui Song, Zhenwei Pan, Zhiren Zhang, Yue Li   +13 more
wiley   +1 more source

Normal Coronary Artery Patient Presenting with Left Ventricular Aneurysm

Case Reports in Medicine, 2011
Left ventricular aneurysm (LVA) is one of the most important complications of myocardial infarction LVA is strictly defined as a distinct area of abnormal left ventricular diastolic contour with systolic dyskinesia or paradoxical bulging.
Hakan Altay, Cihan Altin, Ali Çoner, Haldun Muderrisoglu   +3 more
doaj   +1 more source

FOXM1 Protects Against Myocardial Ischemia‐Reperfusion Injury in Rodent and Porcine Models by Suppressing MKRN1‐Dependent LKB1 Ubiquitination

Advanced Science, EarlyView.
FOXM1 maintains mitochondrial bioenergetic function by inhibiting MKRN1‐mediated ubiquitination of LKB1 in cardiomyocytes. Loss of FOXM1 in cardiomyocytes results in upregulation of MKRN1, which enhances LKB1 ubiquitination and disrupts AMPK signaling and energy metabolism pathways. Conversely, FOXM1 overexpression preserves mitochondrial bioenergetics
Shuai Song, Xiaokai Zhang, Zihang Huang, Zhiqiang Pei, Linqi Zeng, Fengze Cai, Tongyao Wang, Mohan Li, Chenyan Liu, Yining Song, Jiahao Guo, Hao Lu, Xinyu Weng, Li Shen, Xiaochun Zhang, Xingxing Cai, Aijun Sun, Junbo Ge   +17 more
wiley   +1 more source

Incidence rates of dilated cardiomyopathy in adult first-degree relatives versus matched controls

International Journal of Cardiology: Heart & Vasculature, 2022
Background: The incidence rates and importance of traditional risk factors in dilated cardiomyopathy among first-degree relatives are unknown. Methods and Results: We identified all probands with dilated cardiomyopathy (n = 13,714, mean age at diagnosis ...
Charlotte Andersson, Morten Schou, Brian Schwartz, Ramachandran S. Vasan, Mia Nielsen Christiansen, Maria D'Souza, Peter Weeke, Lars Køber, Alex H. Christensen, Gunnar H. Gislason, Christian Torp-Pedersen   +10 more
doaj  

Sex‐ and age‐based differences in the natural history and outcome of dilated cardiomyopathy

European Journal of Heart Failure, 2018
To evaluate the relationship between sex, age and outcome in dilated cardiomyopathy (DCM).
B. Halliday, A. Gulati, Aamir Ali, S. Newsome, Amrit S Lota, U. Tayal, V. Vassiliou, M. Aržanauskaitė, C. Izgi, K. Krishnathasan, A. Singhal, K. Chiew, J. Gregson, M. Frenneaux, S. Cook, D. Pennell, P. Collins, J. Cleland, S. Prasad   +18 more
semanticscholar   +1 more source