Results 101 to 110 of about 3,545,090 (308)

Mitochondrial Calcium Uniporter Drives Chemoresistance in Pancreatic Cancer via Glutathione‐Mediated Stemness Maintenance

open access: yesAdvanced Science, EarlyView.
PDAC has a poor prognosis due to chemoresistance. We revealed that MCU upregulation is associated with chemoresistance and stemness in PDAC. MCU‐mediated Ca2+ influx induced ER stress, activating the PERK‐ATF4/NRF2 axis to enhance PSAT1/SLC711 expression and glutathione synthesis, reducing ROS and maintaining stemness.
Zekun Li   +17 more
wiley   +1 more source

The effect of Physiological NaCl Dilution levels and Storage Duration to Sperm Motility and Abnormality in Muscovy Duck

open access: yesAnimal Production: Indonesian Journal of Animal Production, 2001
The aim of this research are to know the effects of physiological NaCl dilution levels and storage duration on sperm motility and abnormality of  Muscovy duck.
MA Fauzi, Rachmawati WS, Edy Pramono
doaj  

Alkyltriphenylphosphonium Binding to Cardiolipin Triggers Oncosis in Cancer Cells

open access: yesAdvanced Science, EarlyView.
Alkyltriphenylphosphonium, exemplified by TPP+‐C14, preferentially accumulates in mitochondria and selectively binds to cardiolipin, a key phospholipid of the inner mitochondrial membrane, causing loss of mitochondrial membrane potential, severe cellular ATP depletion, and calcium imbalance.
Jin Li   +8 more
wiley   +1 more source

Nonstandard Approach to Gravity for the Dark Sector of the Universe

open access: yesEntropy, 2013
We summarize the present state of research on the darkon fluid as a model for the dark sector of the Universe. Nonrelativistic massless particles are introduced as a realization of the Galilei group in an enlarged phase space.
Wojtek J. Zakrzewski, Peter C. Stichel
doaj   +1 more source

Construction of PANoptosis‐Inhibiting Carbonized Polymer Dots via Machine Learning Potential for Mitigating Chemodrug‐Induced Nephrotoxicity

open access: yesAdvanced Science, EarlyView.
An enhanced sampling method is developed for molecular dynamics based on trained machine learning force fields to guide the construction of PANoptosis‐inhibiting carbonized polymer dots (Lu‐CDs) derived from a flavonoid compound for treating chemodrug‐induced nephrotoxicity.
Xinchen Liu   +8 more
wiley   +1 more source

Effect of the gravitational field strength on the rate of chemical reactions

open access: yesOpen Physics
The magnitude of the rate of chemical reactions also depends on the position in the gravitational field where a chemical reaction is being carried out. The rate of chemical reaction conducted at a stronger gravitational field, i.e., near the surface of ...
Wasif Baig Mirza
doaj   +1 more source

Development of an integrated BEM (Boundary Element Mesh) for hot fluid-structure interaction [PDF]

open access: yes
A boundary integral representation for a coupled approach to fluid flow and solid deformation problems associated with the design of hot-section components such as those in the Space Shuttle Main Engine is discussed.
Banerjee, P. K., Dargush, G. F.
core   +1 more source

Bioabsorbable Endovascular Adhesive Tape (BEAT) for Improving Vascular Regeneration

open access: yesAdvanced Science, EarlyView.
A bioabsorbable endovascular adhesive tape (BEAT) platform based on a hierarchical polyelectrolyte complex is developed to enhance drug delivery in the DCB system. The coating enables rapid transfer to the vessel, provides short‐term mechanical support, and promotes both immediate transfer and long‐term retention of drugs at the lesion site.
Jiarong Wang   +13 more
wiley   +1 more source

Microcystin‐LR Triggers Renal Tubular Ferroptosis Through Epigenetic Repression of GPX4: Implications for Environmental Nephrotoxicity

open access: yesAdvanced Science, EarlyView.
MC‐LR stabilizes DNMT1/3a by blocking their ubiquitin‐mediated degradation, leading to Gpx4 promoter hypermethylation and E2F4/NCoR‐associated transcriptional repression, which drives renal tubular ferroptosis in mice. Pharmacological inhibition of DNA methylation (SGI‐1027) or ferroptosis (Fer‐1) disrupts this DNMT‐GPX4 axis, thereby alleviating MC‐LR‐
Shaoru Zhang   +12 more
wiley   +1 more source

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