Results 91 to 100 of about 62,542 (292)

Circular RNA PTPN4 Contributes to Blood‐Brain Barrier Disruption during Early Epileptogenesis

Advanced Science, EarlyView.
Epileptic condition induces CircPTPN4 upregulation, which promotes ECE‐1 expression through competitive sequestration of miR‐145a‐5p. The elevated ECE‐1 catalyzes the ET‐1 production, leading to p38/MAPK pathway activation and subsequent downregulation of tight junction protein expression. This cascade results in increased BBB permeability and enhanced
Jiurong Yang, Yang Hu, Feiyu Wang, Xintao Peng, Honggang Qi, Yuanyuan Yao, Canyu Zhang, Lijie Zhou, Xuemei Liang, Kang Xu, Cong Zhang, Aifeng Zhang, Chen Chen, Yu Zeng, Chenchen Zhang, Guangming Gan, Xinjian Zhu   +16 more
wiley   +1 more source

Sleep Alters the Velocity of Physiological Brain Pulsations in Humans

Advanced Science, EarlyView.
Sleep alters I/CSF oscillatory flow, driven by increased respiratory (29%) and vasomotor pulsation (21%) velocities, while cardiovascular pulsations decreased by (22%). Velocity is quantified using optical flow analysis of MREG data. Spectral power increases alongside these pulsations (spatial correlation, r = 0.35 and r = 0.39, respectively ...
Ahmed Elabasy, Heta Helakari, Tommi Väyrynen, Zalán Rajna, Niko Huotari, Lauri Raitamaa, Ville Isokoski, Matti Järvelä, Mika Kaakinen, Johanna Piispala, Mika Kallio, Vesa Korhonen, Tapio Seppänen, Vesa Kiviniemi   +13 more
wiley   +1 more source

New attractor mechanism for spherically symmetric extremal black holes

, 2007
We introduce a new attractor mechanism to find the entropy for spherically symmetric extremal black holes. The key ingredient is to find a two-dimensional (2D) dilaton gravity with the dilaton potential $V(\phi)$.
C. Teitelboim, R. Jackiw, Yong-Wan Kim, Young-Jai Park, Yun Soo Myung   +4 more
core   +1 more source

NFS1 Regulates IDH2 to Attenuate Abdominal Aortic Aneurysms via Interacting With SP2

Advanced Science, EarlyView.
The loss of NFS1 leads to its reduced binding with the transcription factor SP2, resulting in decreased expression of the downstream gene Idh2. This causes a shift in energy supply toward glycolysis in VSMCs, ultimately contributing to the occurrence and progression of AAA.
Luzheng Zhang, Yu Zhang, Dezhong Wen, Suxiang Guo, Xiaohui Qi, Heng Wang, Yujin Sun, Guangdong Yang, Yuehong Wang, Song Xue   +9 more
wiley   +1 more source

Detecting the variance in the one-way light speed for linear motion

Results in Optics
A viable solution to detect the one-way speed of light anisotropy in linear motion is by using an Isosceles triangle-shaped design for the experimental setup, from which two light pulses from both ends of one of the triangle’s sides are sent to the same ...
Alex Midasala
doaj   +1 more source

Canonical decomposition of a tetrablock contraction and operator model

, 2016
A triple of commuting operators for which the closed tetrablock $\overline{\mathbb E}$ is a spectral set is called a tetrablock contraction or an $\mathbb E$-contraction. The set $\mathbb E$ is defined as \[ \mathbb E = \{ (x_1,x_2,x_3)\in\mathbb C^3\,:\,
Pal, Sourav
core   +1 more source

Hyperandrogenemia Induces Trophoblast Ferroptosis and Early Pregnancy Loss in Patients With PCOS via CMA‐Dependent FTH1 Degradation

Advanced Science, EarlyView.
In PCOS patients with hyperandrogenemia, decreased ferritin heavy chain 1 (FTH1) causes Fe2⁺ overload and ferroptosis in trophoblasts. Androgens induce FTH1 protein degradation via AR‐LAMP2A‐mediated chaperone‐mediated autophagy pathway, leading to placental development disruption and early pregnancy loss. Metformin mitigates androgen‐induced placental
Hanjing Zhou, Weijie Yang, Na Liu, Qing Liu, Jiamin Jin, Chenqiong Zhao, Xiaoying Jin, Miao Gui, Haiyan Zhu, Songying Zhang, Yinli Zhang   +10 more
wiley   +1 more source

A novel Bessel–Newton algorithm for the simulation of 2D laminar flow between two moving porous walls problem

International Journal of Thermofluids
This work investigates the two-dimensional laminar flow of fluid between two moving porous walls, a key problem in fluid mechanics with implications in filtration, chemical engineering, and biomedical devices.
Atallah El-shenawy, Mohamed El-Gamel, Muhammad E. Anany   +2 more
doaj   +1 more source

Compaction and dilation rate dependence of stresses in gas-fluidized beds

, 2006
A particle dynamics-based hybrid model, consisting of monodisperse spherical solid particles and volume-averaged gas hydrodynamics, is used to study traveling planar waves (one-dimensional traveling waves) of voids formed in gas-fluidized beds of narrow ...
Crowe C. T., Davidson J. F., Derksen J., Gidaspow D., I. G. Kevrekidis, Israelachvili J. N., Jackson R., Jackson R., Moon S. J., Rowe P. N., Rumpf H., S. Sundaresan, Sung Joon Moon, Wen C. Y.   +13 more
core   +1 more source

A simple stress-dilatancy equation for sand

, 2020
13 Pages, 6 Figures, 1 ...
openaire   +2 more sources