Results 101 to 110 of about 62,542 (292)
Advanced Science, EarlyView.PDAC has a poor prognosis due to chemoresistance. We revealed that MCU upregulation is associated with chemoresistance and stemness in PDAC. MCU‐mediated Ca2+ influx induced ER stress, activating the PERK‐ATF4/NRF2 axis to enhance PSAT1/SLC711 expression and glutathione synthesis, reducing ROS and maintaining stemness.
Zekun Li +17 more
wiley +1 more source
A novel solution for ground reaction curve of tunnels in elastoplastic strain softening rock masses
Journal of Civil Engineering and Management, 2017 Ground Reaction Curve (GRC) is one of the most important elements of convergence-confinement method generally used to design tunnels. Realistic presentation of GRC is usually assessed based on the advanced rock strength criteria, also, rock mass behavior
Ali Ghorbani, Hadi Hasanzadehshooiili
doaj +1 more source
On generic homogeneous vector fields
Известия высших учебных заведений. Поволжский регион: Физико-математические науки, 2022 Background. The study of dynamical systems with symmetry is of both theoretical and applied interest. Phase portraits of dynamical systems defined by homogeneous vector fields are invariant with respect to the phase space dilation group.
V.Sh. Roytenberg
doaj +1 more source
A Variational Perspective on Accelerated Methods in Optimization
, 2016 Accelerated gradient methods play a central role in optimization, achieving optimal rates in many settings. While many generalizations and extensions of Nesterov's original acceleration method have been proposed, it is not yet clear what is the natural ...
Jordan, Michael I. +2 more
core +1 more source
Alkyltriphenylphosphonium Binding to Cardiolipin Triggers Oncosis in Cancer Cells
Advanced Science, EarlyView.Alkyltriphenylphosphonium, exemplified by TPP+‐C14, preferentially accumulates in mitochondria and selectively binds to cardiolipin, a key phospholipid of the inner mitochondrial membrane, causing loss of mitochondrial membrane potential, severe cellular ATP depletion, and calcium imbalance.
Jin Li +8 more
wiley +1 more source
Near-optimal mean value estimates for multidimensional Weyl sums
, 2012 We obtain sharp estimates for multidimensional generalisations of Vinogradov's mean value theorem for arbitrary translation-dilation invariant systems, achieving constraints on the number of variables approaching those conjectured to be the best possible.
G.I. Arkhipov +17 more
core +1 more source
Advanced Science, EarlyView.An enhanced sampling method is developed for molecular dynamics based on trained machine learning force fields to guide the construction of PANoptosis‐inhibiting carbonized polymer dots (Lu‐CDs) derived from a flavonoid compound for treating chemodrug‐induced nephrotoxicity.
Xinchen Liu +8 more
wiley +1 more source
Bioabsorbable Endovascular Adhesive Tape (BEAT) for Improving Vascular Regeneration
Advanced Science, EarlyView.A bioabsorbable endovascular adhesive tape (BEAT) platform based on a hierarchical polyelectrolyte complex is developed to enhance drug delivery in the DCB system. The coating enables rapid transfer to the vessel, provides short‐term mechanical support, and promotes both immediate transfer and long‐term retention of drugs at the lesion site.
Jiarong Wang +13 more
wiley +1 more source
Advanced Science, EarlyView.MC‐LR stabilizes DNMT1/3a by blocking their ubiquitin‐mediated degradation, leading to Gpx4 promoter hypermethylation and E2F4/NCoR‐associated transcriptional repression, which drives renal tubular ferroptosis in mice. Pharmacological inhibition of DNA methylation (SGI‐1027) or ferroptosis (Fer‐1) disrupts this DNMT‐GPX4 axis, thereby alleviating MC‐LR‐
Shaoru Zhang +12 more
wiley +1 more source
Dilatation symmetry of the Fokker-Planck equation and anomalous diffusion [PDF]
Physical Review E, 2004 15 pages, no figures, discussions ...
openaire +3 more sources