Results 21 to 30 of about 19,124 (256)
Professionalism and diligence in the age of digital transition
Labour & Law IssuesThe essay addresses the impact that digital-based organizational innovations have on the structure and function of the due diligence rule. After considering the complexity of organizational systems and the need for systematic thought control, the author ...
Antonio Viscomi
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Performance in agile working between organisation by objectives and employer powers
Labour & Law IssuesUnder the employment relationship, the achievement of an objective fixed by the employer may be relevant in terms of verifying the fulfillment of the employment obligation.
Annamaria Donini
doaj +1 more source
Традиционные ценности гагаузов вчера и сегодня [PDF]
Revista de Etnologie şi Culturologie, 2019 One of the long-term priorities of ethno-sociological studies has always been the analysis of the state and development of basic values for different nationalities under the influence of different transformational processes.
Любовь ОСТАПЕНКО +1 more
doaj
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Pakistan Journal of Islamic Research, 2022 The Islamic Shari'ah is the permanent, comprehensive, universal Shari'ah and the source of guidance after abrogation of all the previous Shari'ahs. It contains complete guidance for all aspects of life.
Muhammad Anwar, Hafiz Abdul Basit Khan
doaj
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Due Diligence Obligations and Transboundary Environmental Harm: Cybersecurity Applications
Laws, 2018 This paper analyzes the due diligence obligations with regard to transboundary harm in international water law and their application to cybersecurity by clarifying the definition of due diligence in light of the procedural duties in recent International ...
Akiko Takano
doaj +1 more source
Impact of corporate governance mechanisms on financial reporting quality: a study of Indian GAAP and Indian Accounting Standards [PDF]
Problems and Perspectives in Management, 2020 The present study examines the impact of corporate governance mechanisms on financial reporting quality under Indian GAAP and Indian Accounting Standards (Ind. AS). A sample of 97 companies listed on the Bombay Stock Exchange is selected.
Faozi A. Almaqtari +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source