Results 161 to 170 of about 2,092,591 (384)

Multi‐omic profiling of squamous cell lung cancer identifies metabolites and related genes associated with squamous cell carcinoma

Molecular Oncology, EarlyView.
Using multi‐omic characterization, we aimed to identify key regulators specific to squamous cell lung carcinoma (SqCC). SqCC‐specific differentially expressed genes were integrated with metabolics data. High expression of the creatine transporter SLC6A8, along with elevated creatine levels, appeared to be a distinct metabolic feature of SqCC.
Johan Staaf, Daniel Ehinger, Hans Brunnström, Mats Jönsson, Frida Rosengren, Marija Kotevska, Anna Karlsson, Mattias Aine, Christian Frezza, Maria Planck, Elsa Arbajian   +10 more
wiley   +1 more source

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

Molecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser, Jan Niklas Schäfer, Shraga Nahum Goldberg, Philipp Maximilian Kazmierczak, Moritz Nikolaus Gröper, Philipp Franz Linden, Elif Öcal, Tanja Burkard, Stefanie Corradini, Najib Ben Khaled, Moritz Wildgruber, Max Seidensticker, Jens Ricke, Matthias Stechele, Marianna Alunni‐Fabbroni   +14 more
wiley   +1 more source

THE SIGNIFICANCE OF CONCENTRATION AND DILUTION TESTS IN BRIGHT'S DISEASE [PDF]

, 1934
Alf S. Alving, Donald D. Van Slyke
openalex   +1 more source

Excessive Cell Growth Causes Cytoplasm Dilution And Contributes to Senescence

Cell, 2019
Gabriel E. Neurohr, Rachel L. Terry, Rachel L. Terry, Jette Lengefeld, Megan E. Bonney, Megan E. Bonney, G. Brittingham, Fabien Moretto, Teemu P. Miettinen, Teemu P. Miettinen, L. P. Vaites, L. M. Soares, J. Paulo, J. Harper, S. Buratowski, S. Manalis, F. J. V. Werven, L. Holt, A. Amon   +18 more
semanticscholar   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

DED Powder Modification for Single-Layer Coatings on High-Strength Steels

Journal of Manufacturing and Materials Processing
In the design of L-DED (laser-directed energy deposition) cladding processes, the chemical composition of the metallic powders is typically assumed to match that of the intended coating.
Unai Garate, Enara Mardaras, Jon Arruabarrena, Garikoitz Artola, Aitzol Lamikiz, Luis Norberto López de Lacalle   +5 more
doaj   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Early and late selection: Effects of load, dilution and salience

Frontiers in Psychology, 2014
Tal eMakovski, Bernhard eHommel, Glyn eHumphreys   +2 more
doaj   +1 more source

Dissimilar Welding of Thick Ferritic/Austenitic Steels Plates Using Two Simultaneous Laser Beams in a Single Pass

Journal of Manufacturing and Materials Processing
Dissimilar welds between ferritic and austenitic stainless steels are widely used in industrial applications. Taking into account the issues inherent to arc welding, such as the high heat input and the need to carry out multiple passes in the case of ...
Fabio Giudice, Severino Missori, Andrea Sili   +2 more
doaj   +1 more source