Results 31 to 40 of about 12,584,579 (235)

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Minuta 9 : continuación de los trabajos sobre la matriz de la dimensión Social encomendada por el Grupo a la Secretaría General para la elaboración del Plan de Acción Priorizado de la Dimensión Social (ALADICR/dt 222) /

, 2009
ALADI. Comité de Representantes.
ALADI. Comité de Representantes. Grupo de Trabajo sobre la Dimensión Social en el Proceso de Integración de la ALADI
core   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Divergencias en las dimensiones económicas y sociales de dieciséis empresarios y empresarias desde el género en el desarrollo

Revista de Economía
El objetivo de esta investigación es analizar las relaciones entre las dimensiones económicas y sociales que convergen en el empoderamiento, de una muestra de dieciséis empresarias y empresarios propietarios de una mipyme, pertenecientes a ocho entidades
Gema Jazmín Rubio Ugalde
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Minuta 6 : continuación de los trabajos sobre la matriz de la dimensión Social encomendada por el Grupo a la Secretaría General para la elaboración del Plan de Acción Priorizado de la Dimensión Social

, 2009
ALADI. Comité de Representantes.
ALADI. Comité de Representantes. Grupo de Trabajo sobre la Dimensión Social en el Proceso de Integración de la ALADI
core   +1 more source

Redes e intercambio de capitales en condiciones de pobreza: dimensión relacional y dimensión vincular

REDES: Revista Hispana para el Análisis de Redes Sociales, 2008
Resumen Este trabajo refiere al estudio de las redes sociales implicadas en las estrategias de reproducción social de familias pobres, implicando tanto discusiones teóricas como análisis empíricos. En primer lugar, explicitaré los conceptos de red y de
Alicia Gutiérrez
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source