Results 121 to 130 of about 1,450,380 (307)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

"Tests for Multivariate Analysis of Variance in High Dimension Under Non-Normality" [PDF]

open access: yes
In this article, we consider the problem of testing the equality of mean vectors of dimension ρ of several groups with a common unknown non-singular covariance matrix Σ, based on N independent observation vectors where N may be less than the dimension ρ.
Muni S. Srivastava, Tatsuya Kubokawa
core  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

The CAT(0) dimension of 3-generator Artin groups

open access: yes, 2002
The three generator Artin groups A(m,n.2) are known to be have CAT(O) dimension strictly greater than two if both m and n are odd [BC]. In Chapter 1 we introduce the notions of CAT(O) dimension and three generator Artingroups.In Chapter 2 we show that if
Hanham, Paul Edward
core  

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

open access: yesMolecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge   +17 more
wiley   +1 more source

The European dimension in picture books [PDF]

open access: yes, 1997
This thesis considers European picture books and how they can be used by trainee teachers in upper primary classrooms. It is divided into two parts. Part One, Chapters 1-4, develops a theoretical rationale for creating picture book material which will ...
Cotton, P., Cotton, Penni
core  

Dimension reduction using global and local pattern information-based maximum margin criterion

open access: yes, 2016
Dimension reduction is an important research area in pattern recognition when dealing with high-dimensional data. In this paper, a novel supervised dimension reduction approach is introduced for classification. Advantages of using not only global pattern
Sakarya, Ufuk
core   +1 more source

Systematic Literature Review of Data Quality in Open Government Data: Trend, Methods, and Applications

open access: yesIEEE Access
An open government data (OGD) is an assortment of datasets dumped by government agencies into a portal with the goal of promoting the legitimacy and openness of government operations and processes to citizens.
Zahirah Zainuddin   +1 more
doaj   +1 more source

Techniques of Turnovers’ Evolution and Structure Analysis Using SQL Server 2005 [PDF]

open access: yesTheoretical and Applied Economics, 2007
The turnovers’ evolution and structure analysis can provide many useful information for the construction of a viable set of policies for products, prices and retail network.
Alexandru Manole
doaj  

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

open access: yesMolecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel   +6 more
wiley   +1 more source

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