Results 101 to 110 of about 952,320 (325)

Single‐cell transcriptomics redefines focal neuroendocrine differentiation as a distinct prostate cancer pathology

open access: yesMolecular Oncology, EarlyView.
Single‐cell transcriptomics of prostate cancer patient‐derived xenografts reveals distinct features of neuroendocrine (NE) subtypes. Tumours with focal NE differentiation (NED) share transcriptional programmes with adenocarcinoma, differing from large and small cell neuroendocrine prostate cancer (NEPC). Our work defines the molecular landscape of NEPC,
Rosalia Quezada Urban   +12 more
wiley   +1 more source

The Haagerup property is stable under graph products [PDF]

open access: yes, 2014
The Haagerup property, which is a strong converse of Kazhdan's property $(T)$, has translations and applications in various fields of mathematics such as representation theory, harmonic analysis, operator K-theory and so on. Moreover, this group property
Antolín, Yago, Dreesen, Dennis
core  

Decrypting cancer's spatial code: from single cells to tissue niches

open access: yesMolecular Oncology, EarlyView.
Spatial transcriptomics maps gene activity across tissues, offering powerful insights into how cancer cells are organised, switch states and interact with their surroundings. This review outlines emerging computational, artificial intelligence (AI) and geospatial approaches to define cell states, uncover tumour niches and integrate spatial data with ...
Cenk Celik   +4 more
wiley   +1 more source

Blocking the voltage‐gated sodium channel hNav1.5 as a novel pH‐dependent mechanism of action for tamoxifen

open access: yesFEBS Open Bio, EarlyView.
Patch‐clamp recordings revealed that tamoxifen inhibits voltage‐gated sodium channels, especially under acidic conditions, both common in metastatic cancer cells. These effects may explain certain antitumor properties of tamoxifen, highlighting a novel mechanism of action beyond its known endocrine effects.
Karl Josef Föhr   +5 more
wiley   +1 more source

Metric Dimension of Amalgamation of Graphs [PDF]

open access: yes, 2013
A set of vertices $S$ resolves a graph $G$ if every vertex is uniquely determined by its vector of distances to the vertices in $S$. The metric dimension of $G$ is the minimum cardinality of a resolving set of $G$.
Saputro, Suhadi Wido   +2 more
core  

Most autophagic cell death studies lack evidence of causality

open access: yesFEBS Open Bio, EarlyView.
Of 104 studies claiming autophagic cell death (ACD), only 13 demonstrated both causality and exclusion of apoptosis to confirm true ACD. Most studies relied on correlation‐level data or measured autophagy in isolation, revealing pervasive methodological shortcomings.
Ali Burak Özkaya, Yasmin Ghaseminejad
wiley   +1 more source

Universal scaling in real dimension

open access: yesNature Communications
The concept of universality has shaped our understanding of many-body physics, but is mostly limited to homogenous systems. Here, we present a study of universality on a non-homogeneous graph, the long-range diluted graph (LRDG).
Giacomo Bighin   +2 more
doaj   +1 more source

Fault-Tolerant Metric Dimension of Interconnection Networks

open access: yesIEEE Access, 2020
A fixed interconnection parallel architecture is characterized by a graph, with vertices corresponding to processing nodes and edges representing communication links.
Sakander Hayat   +4 more
doaj   +1 more source

New Integrable 4D Quantum Field Theories from Strongly Deformed Planar N=4 Supersymmetric Yang-Mills Theory.

open access: yesPhysical Review Letters, 2016
We introduce a family of new integrable quantum field theories in four dimensions by considering the γ-deformed N=4 supersymmetric Yang-Mills (SYM) theory in the double scaling limit of large imaginary twists and small coupling.
Ö. Gürdoğan, V. Kazakov
semanticscholar   +1 more source

Spinal Cord Abnormalities in Early Pediatric Multiple Sclerosis

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Spinal cord lesions and atrophy in the cervical region are common in adult multiple sclerosis (MS) and correlate with disability. Whether similar abnormalities occur in pediatric MS patients is largely unknown. Clinical and MRI evaluations were performed in 38 pediatric MS patients and 13 healthy controls (HC).
Monica Margoni   +7 more
wiley   +1 more source

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