Results 51 to 60 of about 507,335 (290)

Edge-based metric resolvability of anti-depression molecular structures and its application

Results in Chemistry
Chemical graph theory represents an interdisciplinary field at the intersection of chemistry and mathematics, focusing on the analysis of various chemical structures through graph-theoretical frameworks.
Rab Nawaz, Muhammad Kamran Jamil, Muhammad Azeem   +2 more
doaj   +1 more source

Topological Descriptor of 2-Dimensional Silicon Carbons and Their Applications

Open Chemistry, 2019
The Chemical graph theory is extensively used in finding the atomic supplementary properties of different chemical stuructures. Many results of graph theory are commonly used in molecular structures and in general in Chemisty.
Nadeem Muhammad, Ahmad Sarfraz, Siddiqui Muhammad Kamran, Naeem Muhammad   +3 more
doaj   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

The multiplicative coalescent, inhomogeneous continuum random trees, and new universality classes for critical random graphs [PDF]

, 2017
One major open conjecture in the area of critical random graphs, formulated by statistical physicists, and supported by a large amount of numerical evidence over the last decade [23, 24, 28, 63] is as follows: for a wide array of random graph models with
Bhamidi, Shankar, Sen, Sanchayan, van der Hofstad, Remco   +2 more
core   +3 more sources

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Compactification in the Lightlike Limit

, 1997
We study field theories in the limit that a compactified dimension becomes lightlike. In almost all cases the amplitudes at each order of perturbation theory diverge in the limit, due to strong interactions among the longitudinal zero modes.
A. Casher, A. Sen, C. B. Thorn, H. C. Pauli, H. C. Pauli, J. Wess, Joseph Polchinski, K. Becker, M. Dine, M. R. Douglas, N. Seiberg, O. J. Ganor, R. Giles, S. P. de Alwis, S. Weinberg, Simeon Hellerman, T. Banks, T. Maskawa   +17 more
core   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Partition Dimension of Generalized Hexagonal Cellular Networks and Its Application

IEEE Access
The notion of partition dimension was initially introduced in the field of graph theory, primarily to examine distances between vertices. The local partition dimension extends this idea by incorporating specific conditions into how vertices are ...
Rabnawaz Bhatti, Muhammad Kamran Jamil, Muhammad Azeem, Prasanna Poojary   +3 more
doaj   +1 more source

Mixed metric dimension of hollow coronoid structure

Ain Shams Engineering Journal, 2023
Coronoid systems actually arrangements of hexagons into six sides of benzenoids. By nature, it is an organic chemical structure. Hollow coronoids are primitive and catacondensed coronoids. It is also known as polycyclic conjugated hydrocarbons.
Ali N.A. Koam, Ali Ahmad, Sadia Husain, Muhammad Azeem   +3 more
doaj   +1 more source