Results 31 to 40 of about 431,192 (269)
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Research on compaction and permeability characteristics of gravel soil roadbed filler
工程科学学报To elucidate the rules of particle crushing and loss of gravel soil subgrade filler during compaction and penetration, we performed compaction and permeability tests of gravel soil samples with different stone and moisture contents; moreover, crushing ...
Shengang LI +3 more
doaj +1 more source
RIPK4 function interferes with melanoma cell adhesion and metastasis
Molecular Oncology, EarlyView.RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski +9 more
wiley +1 more source
DDX3X induces mesenchymal transition of endothelial cells by disrupting BMPR2 signaling
FEBS Open Bio, EarlyView.Elevated DDX3X expression led to downregulation of BMPR2, a key regulator of endothelial homeostasis and function. Our co‐immunoprecipitation assays further demonstrated a molecular interaction between DDX3X and BMPR2. Notably, DDX3X promoted lysosomal degradation of BMPR2, thereby impairing its downstream signaling and facilitating endothelial‐to ...
Yu Zhang +7 more
wiley +1 more source
Rudarsko-geološko-naftni Zbornik, 1991 The paper presents a survey of the possible origins of the strain and deformation of stone. A range of origins which can be influenced is suggested, from those occurring under natural conditions in the deposit to those resulting from technologies applied
Branko Crnković
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Asvanced modern techniques for exploitation of dimension stones [PDF]
, 2013 In this paper work are given some techniques of the exploitation of dimension stones in some of the more important Mines in the Republic of Macedonia.
Dambov, Risto +3 more
core
, 2016 Experiencing the landscape and skyscape in which for example an astronomically relevant ancient site is located allows for a deep exploration of possible meanings of embedded alignments.
Brown, D
core +1 more source
Lessons Learned From a Delayed‐Start Trial of Modafinil for Freezing of Gait in Parkinson's Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Freezing of gait (FOG) in people with Parkinson's disease (PwPD) is debilitating and has limited treatments. Modafinil modulates beta/gamma band activity in the pedunculopontine nucleus (PPN), like PPN deep brain stimulation. We therefore tested the hypothesis that Modafinil would improve FOG in PwPD.
Tuhin Virmani +8 more
wiley +1 more source
Rudarsko-geološko-naftni Zbornik, 2012 Dimension stone is a highly valuable mineral raw material per unit of product. From the past experiences and literature it is known that for a certain quantity of commercial blocks, dimension stone should be dug (cut) out is significantly larger volume ...
Dragan Vidić +2 more
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