Results 61 to 70 of about 8,548,248 (305)

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

The influence of the raster angle on the dimensional accuracy of FDM-printed PLA, PETG, and ABS tensile specimens

European Mechanical Science
3D printing is a rapidly advancing method in digital manufacturing techniques and produces objects in layers. Fused Deposition Modelling (FDM) is a 3D printing technology where the material is melted in a hot nozzle and then placed on a build platform to
Oğuz Tunçel
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Effect of Fused Filament Fabrication Parameters on Selected Indicators for Assessing Technological Quality of Shaped Models

Applied Sciences
Despite many studies, implementation of the additive manufacturing process in industrial and research practice is limited due to the numerous distortions affecting the obtained dependencies to a degree that is difficult to predict. No uniform methodology
Marek Łoś, Wojciech Zawadka, Krzysztof Nadolny   +2 more
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Evaluation and Comparison of the Dimensional Accuracy of Resultant Casts Made by Monophase Polyether and Monophase Addition Silicone Impression Materials − An In Vitro Study

Journal of Orofacial Sciences
Introduction: Dimensional accuracy when making impressions is crucial to the quality of fixed prosthodontics treatment, and impression materials are critical factors affecting this accuracy.
Raveena Makker, Vivek Choukse, Shilpi G Gupta, Rajeev Srivastava, Sourabh Khandelwal, Prashanthi Reddy   +5 more
doaj   +1 more source

Experimental Analysis of the Effect of Compressive Force Resulting from the Initial Distance on the Improvement of Dimensional Accuracy Using Fluorinated Ethylene Propylene Membranes with Different Thicknesses in Digital Light Processing Method [PDF]

مکانیک هوافضا, 2023
The additive manufacturing method, as the newest way of producing parts in medicinal and industrial fields, has made significant advancements in recent years.
Mohammad Salehi, Jamal Zamani Ashani, Siavash Moayedi Manizani   +2 more
doaj  

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Machinability and Geometric Evaluation of FFF-Printed PLA-Carbon Fiber Composites in CNC Turning Operations

Applied Sciences
Fused Filament Fabrication (FFF) enables the manufacturing of complex polymer components. However, surface finish and dimensional accuracy remain key limitations for their integration into functional assemblies.
Sergio Martín-Béjar, Fermín Bañón-García, Carolina Bermudo Gamboa, Lorenzo Sevilla Hurtado   +3 more
doaj   +1 more source