Results 91 to 100 of about 601,504 (262)

Dimensional reduction in quantum optics

Physical Review Research
One-dimensional quantum optical models usually rest on the intuition of large-scale separation or frozen dynamics associated with the different spatial dimensions, for example when studying quasi one-dimensional atomic dynamics, potentially resulting in ...
Jannik Ströhle, Richard Lopp
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

On dimensional reduction of magical supergravity theories

Physics Letters B, 2016
We prove, by a direct dimensional reduction and an explicit construction of the group manifold, that the nonlinear sigma model of the dimensionally reduced three-dimensional A=R magical supergravity is F4(+4)/(USp(6)×SU(2)).
Naoto Kan, Shun'ya Mizoguchi
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Preservation of Dissipativity in Dimensionality Reduction

Communications in Nonlinear Science and Numerical Simulation
Systems with predetermined Lyapunov functions play an important role in many areas of applied mathematics, physics and engineering: dynamic optimization methods (objective functions and their modifications), machine learning (loss functions), thermodynamics and kinetics (free energy and other thermodynamic potentials), adaptive control (various ...
Sergey V. Stasenko, Alexander N. Kirdin
openaire   +2 more sources

Editorial: Statistical methods for analyzing multiple environmental quantitative genomic data

Frontiers in Genetics, 2023
Zitong Li, Lucia Gutierrez
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Understanding the evolution of double perovskite band structure upon dimensional reduction. [PDF]

Chem Sci, 2023
Connor BA, Su AC, Slavney AH, Leppert L, Karunadasa HI.   +4 more
europepmc   +1 more source