Results 61 to 70 of about 316,362 (306)
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Feasibility Theory Reconciles and Informs Alternative Approaches to Neuromuscular Control
Frontiers in Computational Neuroscience, 2018 We present Feasibility Theory, a conceptual and computational framework to unify today's theories of neuromuscular control. We begin by describing how the musculoskeletal anatomy of the limb, the need to control individual tendons, and the physics of a ...
Brian A. Cohn +4 more
doaj +1 more source
Two-Dimensional Signatures [PDF]
Journal of Applied Probability, 2012 The notion of the signature is a basic concept and a powerful tool in the analysis of networks and reliability systems of binary type. An appropriate definition of this concept has recently been introduced for systems that have ν possible states (with ν ≥ 3).
Ilya Gertsbakh +2 more
openaire +5 more sources
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Equivalence of Partition Functions Leads to Classification of Entropies and Means
Entropy, 2012 We derive a two-parameter family of generalized entropies, <em>S<sub>pq</sub></em>, and means <em>m<sub>pq</sub></em>. To this end, assume that we want to calculate an entropy and a mean for <em>n</
Michel S. Elnaggar, Achim Kempf
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Nonlinear Dynamic Field Embedding: On Hyperspectral Scene Visualization [PDF]
, 2012 In many areas of research, complex signals are commonly represented by high dimensional feature vectors. However, high dimensional vectors are difficult to analyze and interpret due to the curse of dimensionality.
Lunga, Dalton, Erosy, Okan
core
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Cailiao gongcheng, 2019 Comprehensive high-performance epoxy nanocomposites were successfully prepared by co-incorporating 2-dimensional montmorillonite (MMT) and 0-dimensional nano TiO2 co-incorporated into epoxy.
LI Xi
doaj +1 more source
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source