Results 201 to 210 of about 9,464 (283)

The Role of SAMHD1 in Viral Resistance and Transduction Efficiency Challenges in Pediatric Hematological Malignancies: Mechanistic Insights and Clinical Perspectives

European Journal of Haematology, EarlyView.
SAMHD1 regulates intracellular dNTP pools, influencing lentiviral transduction, gene therapy efficiency, and disease progression in pediatric hematological malignancies. Integrated bioinformatics and targeted strategies, including CRISPR and pharmacological inhibition, highlight its therapeutic potential.
Waseem Alzamzami
wiley   +1 more source

Interactions between small leucine‐rich proteoglycans and proteases: implications for tissue homeostasis and pathology

The FEBS Journal, EarlyView.
Small leucine‐rich proteoglycans (SLRPs) are key modulators of extracellular matrix structure and signaling. Their proteolytic processing by MMPs (Matrix Metalloproteinases), ADAMTS (disintegrin and metalloprotease with thrombospondin motifs), and serine proteases generates bioactive fragments that regulate collagen remodeling, inflammation, and ...
Maria Konstantaraki, Lydia‐Nefeli Thrapsanioti, Aikaterini Berdiaki, Ioanna Spyridaki, Dragana Nikitovic   +4 more
wiley   +1 more source

Transgenerational inheritance of diminished ovarian reserve triggered by prenatal propylparaben exposure in mice. [PDF]

Nat Commun
Li M, Wu Y, Wei S, Zhang T, Yan W, Gao Y, Chen Y, Hu D, Wu T, Li M, Wang W, Li Y, Zhou S, He X, Wang S, Zhang J.   +15 more
europepmc   +1 more source

Diminished ovarian reserve and adverse reproductive outcomes

, 2017
Starting a family later in life is a trend of the last decades. For women, delaying childbearing to their mid-thirties means trying to conceive in a period in which fecundity, i.e., the capacity to conceive is already declining. The decline in the capacity to conceive is associated with the loss of oocytes, the female germline cells.
openaire   +1 more source

Dialysis and Pregnancy: Optimizing Therapy for Best Maternal and Fetal Outcomes

Hemodialysis International, EarlyView.
ABSTRACT Pregnancy in women with end‐stage kidney disease (ESKD) requiring dialysis remains high risk, with significant maternal and fetal complications. While fertility rates are markedly reduced in this population, advances in dialysis care and obstetric management have led to increasing reports of successful pregnancies.
Shreepriya Mangalgi, Silvi Shah
wiley   +1 more source

Loss of Posterior Occlusal Support Is Associated With Incident Steatotic Liver Disease in a Nationwide Longitudinal Analysis of the JMDC Claims Database

Hepatology Research, EarlyView.
ABSTRACT Aim Steatotic liver disease (SLD), including metabolic dysfunction–associated SLD (MASLD) and metabolic dysfunction–associated alcohol‐related liver disease (MetALD), is a growing global health burden. Although impaired mastication is linked to metabolic disorders, its role in SLD remains unclear.
Takashi Miyano, Taro Kusama, Manami Hoshi‐Harada, Ken Osaka, Kenji Takeuchi   +4 more
wiley   +1 more source

Vectors and Vector‐Borne Diseases: Biology, Epidemiology and Integrated Control Strategies

Journal of Applied Entomology, EarlyView.
ABSTRACT Vector‐Borne Diseases (VBDs), transmitted by arthropods such as mosquitoes, ticks, fleas and sandflies, represent a significant threat to global health. These diseases can be caused by a variety of pathogens, including bacteria, viruses, protozoa, and helminths.
Roberta Rinaldi, Carmen Scieuzo, Federica De Stefano, Luca Masucci, Patrizia Falabella   +4 more
wiley   +1 more source

Determination of the optimal follicle size at the time of trigger in patients with diminished ovarian reserve undergoing ICSI cycle. [PDF]

J Ovarian Res
Naghshineh E, Tehrani HG, Mehrabian F, Mardanian F, Rezaei M.   +4 more
europepmc   +1 more source

Prospects of multipurpose biomonitoring for fisheries assessment based on environmental nucleic acids

Journal of Fish Biology, EarlyView.
Abstract Methods using environmental nucleic acids have become highly effective for monitoring aquatic biodiversity, with an array of suitable use cases, including metrics for fisheries assessment. Traditional methods for assessing fish populations often rely on invasive techniques with limited spatial and temporal coverage.
Ana Ramón‐Laca, Krista M. Nichols, Kim M. Parsons, Ramón Gallego, David R. Vieites, Ignacio Doadrio, Ana Riesgo   +6 more
wiley   +1 more source

Yangjingzhongyu Decoction regulates primordial follicle initiation via LncRNA-Smad1/AMPK dual pathways in diminished ovarian reserve. [PDF]

J Ovarian Res
Li W, Zhang J, Shi D, Wang J, Luo S, Yang J, Deng D.   +6 more
europepmc   +1 more source