Results 51 to 60 of about 47,828 (266)

Genetic Ablation and Multi‐Omics Profiling Reveal CEP55 as a Key Driver of Tumorigenesis in Diverse Cancer Models

Advanced Science, EarlyView.
Genetic ablation of Cep55 in Pten‐deficient mouse models delays tumorigenesis. Integrated multi‐omics analyses (proteomics, phosphoproteomics, and spatial transcriptomics) reveal that CEP55 regulates oncogenic signaling (RAS/ERK, PI3K/AKT), integrin/FAK‐mediated adhesion, extracellular matrix (ECM) remodeling, and endocytosis.
Behnam Rashidieh, Yuanhao Yang, Amanda Louise Bain, Phillip Theron, Catharina Vosloo, Sahar Keshvari, Parinaz Ahangar, Brydie Bowden, Simon M. Tria, Ben B. Wang, Sandra Isenmann, Nicholas J. Westra van Holthe, Zherui Xiong, Hani Vu, Sowmya Sharma, Asmerom Sengal, J. Alejandro Lopez, John Finnie, Antonella Papa, Pascal H.G. Duijf, Quan Nguyen, Pirjo M. Apaja, Kum Kum Khanna   +22 more
wiley   +1 more source

Loss of SHP1 in Spinal Astrocytes Triggers T‐Lymphocyte Infiltration and Nociceptive Hypersensitivity

Advanced Science, EarlyView.
Astrocyte‐specific SHP1 deletion disrupts astrocyte–vascular interactions and compromises BBB integrity while enhancing STAT1‐dependent CXCL10 expression. These changes synergistically promote peripheral CD4+ and CD8+ T‐cell infiltration into the SDH. The infiltrating T cells secrete IFN‐γ, which in turn activates microglia.
Lan‐Xing Yi, Lin Yang, Kang‐Li Wang, Hui‐Zhu Liu, Rui‐Ying Chen, Min Su, Xiao Xiao, Yu‐Qiu Zhang   +7 more
wiley   +1 more source

Application of a novel schema for describing fossil fern foliage and investigating taxonomic and morphological change across the Cretaceous–Paleogene boundary in western North America

American Journal of Botany, EarlyView.
Abstract Premise The Chicxulub asteroid impact at the Cretaceous–Paleogene (K–Pg) boundary triggered a mass extinction 66 million years ago. Ferns thrived in the aftermath of the extinction, evidenced by the well‐documented “fern spore spike.” However, fern macrofossil records across the K–Pg boundary are less understood.
Fern B. Holian, Emily B. Sessa, Richard S. Barclay, Regan E. Dunn, Jacquelyn L. Gill, Kirk R. Johnson, S. Augusta Maccracken, Ian M. Miller, Jarmila Pittermann, Ellen D. Currano   +9 more
wiley   +1 more source

POLLEN DIMORPHISM IN THE RUBIACEAE [PDF]

Evolution, 1956
The striking dimorphism of pollen and stigmata fonnd in the majority of the species of the tribe Staticeae in the Plumbaginaceae was discovered by McCleod (1887). This dimorphism and derived monomorphic conditions have been extensively investigated with results that have been found extremely helpful in the elucidation of genetical, genecological ...
openaire   +1 more source

Sexual dimorphism for juvenile body weight in chickens divergently selected for 8-week body weight

Frontiers in Physiology
There is a dearth of literature on the genetics of sexual dimorphism for juvenile body weight in meat-type chickens given its biological and economic relevance. Herein, we report the sexual dimorphism for 4- and 8-week body weights in White Plymouth Rock
Paul B. Siegel, Christa F. Honaker
doaj   +1 more source

Female‐Specific Risk of TAS2R Variants in Chronic Rhinosinusitis: A Hospital‐Based Cohort Study From the Taiwan Precision Medicine Initiative

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Bitter taste receptors (T2Rs) function in the innate immune defense of the sinonasal mucosa; however, the genetic association between the TAS2R gene family and chronic rhinosinusitis (CRS) remains understudied in Asian populations.
Rong‐San Jiang, Man‐Wei Hua, I‐Chieh Chen, Yi‐Ming Chen, Shun‐Hung Lin, Kuan‐Yu Lai, Yi‐Chen Chen   +6 more
wiley   +1 more source

The morphology of the oval window in Paranthropus robustus compared to humans and other modern primates

The Anatomical Record, EarlyView.
Abstract The oval window (OW) is an opening connecting the inner and middle ear. Its area has been shown to consistently scale with body mass (BM) in primates, and has been used alongside semi‐circular canal (SCC) size to differentiate Homo sapiens and fossil hominins, including Paranthropus robustus.
Ruy Fernandez, José Braga
wiley   +1 more source

Wing dimorphism in aphids [PDF]

Heredity, 2006
Many species of insects display dispersing and nondispersing morphs. Among these, aphids are one of the best examples of taxa that have evolved specialized morphs for dispersal versus reproduction. The dispersing morphs typically possess a full set of wings as well as a sensory and reproductive physiology that is adapted to flight and reproducing in a ...
Braendle, Christian, Davis, Gregory, Brisson, Jennifer, Stern, David   +3 more
openaire   +3 more sources

Comparative analysis of cephalofacial dimorphism among indigenous ethnic groups in Benue State, Nigeria

Journal of Forensic Science and Medicine, 2020
The face is an important physiognomic feature in humans, and facial anthropometric variables are valuable biometric physiognomies that vary with age, sex, and ethnicity.
Joseph Igbo Enya, Onenson Nkanu Onen
doaj   +1 more source

Revisiting paravertebral muscles in European rabbits (Oryctolagus cuniculus) and European brown hares (Lepus europaeus) (Leporidae; Lagomorpha)

The Anatomical Record, EarlyView.
Abstract Domesticated European rabbits (Oryctolagus cuniculus) have long been chosen as laboratory model organisms. Despite this, there has been no definitive study of the vertebral musculature of wild rabbits. Relevant descriptions of well‐studied veterinary model mammals (such as dogs) are generally applicable, but not appropriate for a species ...
Nuttakorn Taewcharoen, Emma Sherratt, Philip Stott, Rachel Norris   +3 more
wiley   +1 more source