Results 81 to 90 of about 5,838 (234)

KCNJ4 variants disrupt inward‐rectifier potassium channel function and cause refractory epilepsy

Epilepsia, EarlyView.
Abstract Objective Epilepsy is a common neurological disorder with a strong genetic basis, most frequently arising from ion channel dysfunction. Although multiple inwardly rectifying potassium (Kir) channels have been implicated in epileptogenesis, the contribution of KCNJ4, which encodes the Kir2.3 channel, has not previously been established in human
Hu Pan, Deng Liu, Wuhen Xu, Yang Li, Juanli Hu, Oppermann Henry, Alexander Fuchs, Rami Abou Jamra, Zhen Liu, Mei He, Yuanlu Chen, Shengnan Wu, Xiaohuan Dong, Yiqiao Chen, Pengchao Wang, Weiyue Gu, Han Jing, Yabing Tang, Ya‐Jie Wang, Xiao Mao, Neng Xiao   +20 more
wiley   +1 more source

Analysis and Implementation of the MNRV DPWM Methods Applied to Single-Phase Diode-Clamped Four-Level PWM Inverter

IEEE Access
This paper introduces the multi-neighboring reference vector discontinuous pulse-width modulation (MNRV DPWM) with offset voltage injection methodology tailored for single-phase diode-clamped four-level PWM inverters.
Min-Sup Song
doaj   +1 more source

Multilevel Converters: An Enabling Technology for High-Power Applications [PDF]

, 2009
| Multilevel converters are considered today as the state-of-the-art power-conversion systems for high-power and power-quality demanding applications.
García Franquelo, Leopoldo, Kouro, Samir, León Galván, José Ignacio, Martín Prats, María de los Ángeles, Portillo Guisado, Ramón Carlos, Pérez, Marcelo, Rodríguez, José   +6 more
core  

Embedding Fiber Segment Interferometry for Localization of Defects in Composite Structures

Polymer Composites, EarlyView.
Graphical representation of composite structures with embedded fiber optic sensors for structural health monitoring, enabling strain measurement and damage localization under mechanical loading. ABSTRACT In the area of structural health monitoring (SHM), embedding strain sensors into smart composites is a key strategy for detecting failures arising ...
Shiva Mohammadkarimi, Christoph Hemeling, Thomas Kissinger, Florian Puch   +3 more
wiley   +1 more source

Three-Phase Diode-Clamped Four-Level PWM Inverter With Offset Voltage Injection

IEEE Access
In this paper, a three-phase diode-clamped four-level PWM inverter with offset voltage injection is proposed. The proposed inverter is based on multi-neighboring reference vector (discontinuous) pulse-width modulation (MNRV (D)PWM), where multiple ...
Min-Sup Song, Jaewon Kim, Hwan-Hee Cho
doaj   +1 more source

Highly Dynamic Soft Electrohydraulic Origami Actuators for Agile and Multimodal Robotic Locomotion

SmartBot, EarlyView.
Most current soft robots still lag far behind their natural counterparts in both agility and speed, mainly attributed to the limited morphing modes and performance of soft actuators. Here, the authors report a new methodology of electrohydraulic origami (EHO) for creating powerful and multimodal soft actuators with large strain, high speed, lightweight,
Wenbo Li, Yuanzhen Zhang, Guorui Li, Hai Li, Kai Tao, Wenming Zhang, Jian Xu   +6 more
wiley   +1 more source

Derivation of Voltage Source Multilevel Converter Topologies [PDF]

, 2017
Multilevel converters have gained popularity in both medium voltage and low voltage applications. To find out the connections between various multilevel voltage-source converter topologies and to reveal how to obtain new topologies, this paper has ...
Yuan, Xibo
core   +2 more sources

In Vitro Reconstruction of Axonal Heat Sensing with a Photothermal Nerve‐on‐a‐Chip

Small, EarlyView.
A photothermal nerve‐on‐a‐chip platform is presented that enables precise, localized heating of sensory axons with simultaneous electrical recording. The system reveals millisecond‐scale dynamics of heat‐evoked neural activity and provides a new approach to study how temperature‐dependent ion channel behavior is translated into axonal firing.
Koji Sakai, Yujiro Tanaka, Riku Takahashi, Toichiro Goto, Yosuke Mizuno, Taiki Otomo, Aya Tanaka   +6 more
wiley   +1 more source

Therapeutic potential of small molecules that block receptor‐induced Kv7/M‐current suppression in neuroprotection, seizures, and pain

British Journal of Pharmacology, EarlyView.
Receptor‐induced Kv7/M‐current suppression increases neuronal activity and contributes to pathology of several conditions. A new class of Kv7 modulators identified in this study attenuates M‐current suppression and shows therapeutic effects. Abstract Background and Purpose Neuronal Kv7 channels generate low voltage–gated potassium currents known as the
Young Woo Kim, Pavan Kumar Behara, Lamees Alhassen, Cindy Wong, Olivier Civelli, Naoto Hoshi   +5 more
wiley   +1 more source

The Essential Role and the Continuous Evolution of Modulation Techniques for Voltage-Source Inverters in the Past, Present, and Future Power Electronics [PDF]

, 2016
The cost reduction of power-electronic devices, the increase in their reliability, efficiency, and power capability, and lower development times, together with more demanding application requirements, has driven the development of several new inverter ...
García Franquelo, Leopoldo, Kouro, Samir, León Galván, José Ignacio, Rodríguez, José, Wu, Bin   +4 more
core   +1 more source