Results 61 to 70 of about 1,185,282 (312)

Regulating Tumor Metabolic Reprogramming with Biomimetic Co‐Delivery of Simvastatin and Kynureninase for Immunotherapy

open access: yesAdvanced Science, EarlyView.
After the intravenous injection of biomimetic and pH/ROS‐responsive PTSK@CRM, the nanoparticles can be accumulated in tumors and release Sim and KYNase to inhibit the tumor growth, regulate the metabolism of cholesterol and Kyn, and reverse the immunosuppressive tumor microenvironment.
Jiaxin Yin   +6 more
wiley   +1 more source

La cara oculta del Concilio Vaticano I

open access: yesEstudios Eclesiásticos, 1970
El Concilio Vaticano I y el Vaticano II se distinguen entre sí en el estilo o talante, pues en el fondo la teología es similar. Desde esta perspectiva, se analizan las tres fases conciliares del Vaticano I donde se puede percibir una vida indestructible ...
Justo Collantes
doaj  

Temas y pensamiento en el poema "Espacio" de Juan Ramón Jiménez: el cronotopos tiempo-espacio, Dios, el cuerpo de la conciencia y el amor

open access: yesNueva Revista de Filología Hispánica, 2017
Recepción: 29 de mayo de 2016. Aceptación: 23 de noviembre de 2016. Decía Octavio Paz que Espacio de Juan Ramón Jiménez era “un monumento de la conciencia poética contemporánea”.
Juan José Rastrollo Torres
doaj   +1 more source

Baruch Spinoza y G. W. F. Hegel: esbozo de un posible contraste en torno a la idea de Dios [PDF]

open access: yes, 2009
El presente trabajo contiene un esbozo del contraste que existe en torno a la idea de Dios entre Baruch Spinoza y Wilhelm Hegel. Ambas concepciones poseen en común el hecho de que la tematización realizada en torno de la divinidad puede asimismo ...
GONZALEZ, RUSH, GONZALEZ, RUSH
core  

Dysfunctional TRIM31 of POMC Neurons Provokes Hypothalamic Injury and Peripheral Metabolic Disorder under Long‐Term Fine Particulate Matter Exposure

open access: yesAdvanced Science, EarlyView.
Particulate matter ≤2.5 µm (PM2.5) elevates risks of neurological and chronic metabolic diseases, but the underlying mechanisms linking PM2.5‐induced central nervous system (CNS) injury to metabolic dysfunction remain unclear. Hypothalamic pro‐opiomelanocortin‐expressing (POMC+) neurons regulate systemic metabolic homeostasis, and tripartite motif ...
Chenxu Ge   +21 more
wiley   +1 more source

Muon energy reconstruction in ANTARES and its application to the diffuse neutrino flux [PDF]

open access: yes, 2003
The European collaboration ANTARES aims to operate a large neutrino telescope in the Mediterranean Sea, 2400 m deep, 40 km from Toulon (France).
Bruijn, Ronald   +2 more
core   +2 more sources

Remimazolam Ameliorates Autistic‐Like Behaviors via Suppression of Ferroptosis in VTA Dopaminergic Neurons in a Mouse Model of ASD

open access: yesAdvanced Science, EarlyView.
The ultra‐short‐acting sedative remimazolam has a sustained therapeutic effect on the core symptoms of VPA‐exposed mice. Remimazolam, a GABA agonist, exerts its therapeutic effects by protecting dopamine neurons in the VTA of VPA‐exposed mice. Meanwhile, ferroptosis is the critical mechanism by which remimazolam protects VTA dopaminergic neurons and ...
Yuxin Zhang   +7 more
wiley   +1 more source

Descartes y Nietzsche: perspectivas acerca del cuerpo

open access: yesPerseitas, 2020
El presente artículo rastrea las concepciones del cuerpo en los planteamientos del filósofo francés René Descartes y del filósofo alemán Friedrich Nietzsche.
Julián Ospina Saldarriaga
doaj   +1 more source

Flavonoid diosmetin increases ATP levels in kidney cells and relieves ATP depleting effect of ochratoxin A [PDF]

open access: yes, 2014
Diosmetin (DIOS) is a flavone aglycone commonly occurring in citrus species and olive leaves, in addition it is one of the active ingredients of some medications.
Antus, Csenge   +8 more
core   +1 more source

Hyperviscous Diabetic Bone Marrow Niche Impairs BMSCs Osteogenesis via TRPV2‐Mediated Cytoskeletal‐Nuclear Mechanotransduction

open access: yesAdvanced Science, EarlyView.
Diabetic bone marrow exhibits pathological ECM hyperviscosity that activates TRPV2‐mediated Ca2⁺ influx, leading to perinuclear F‐actin disassembly, nuclear deformation, and chromatin condensation. This cytoskeletal‐nuclear decoupling suppresses osteogenic differentiation of BMSCs.
Yao Wen   +8 more
wiley   +1 more source

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